Displaying 1 - 585 of 585 tests
OCT4 Octamer Binding Transcription Factor 4 (OCT4, also known as OCT3/4, POU51) is a transcription factor and is expressed by early embryonic cells, germ cells, and stem cells. OCT4 is a nuclear marker of…
Immunohistochemistry (IHC)
JAK2 V617F Mutation Analysis Qualitative detection of the V617F mutation. The rare mutation V617I is also detected. Testing is performed on plasma for increased sensitivity whenever possible. V617F testing may be ordered…
Molecular
MPL Mutation Analysis Bi-directional sequencing of exon 10 of the MPL gene to detect all possible mutations at the W515 and S505 codons, and other mutations throughout the exon. Testing is performed on plasma for…
Molecular
MPN Extended Reflex Panel Sequential testing panel including qualitative detection of JAK2 V617F, JAK2 Exon 12-14, CALR exon 9, and MPL exon 10. Testing proceeds by reflex through the four-step panel until a mutation is…
Molecular
p21 p21 is a cyclin dependent protein kinase inhibitor and is a member of a family of proteins that functions to slow down cell division. p21 is found in t cells as they transitions from G1 phase to S…
Immunohistochemistry (IHC)
p27 p27 (KIP1) belongs to the family of cell cycle regulators that cause cell cycle arrest in G1 phase. p27 promotes apoptosis, plays a role in terminal differentiation of some tissues and mediates…
Immunohistochemistry (IHC)
p40 p40 antibody recognizes ΔNp63—a p63 isoform. It is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential…
Immunohistochemistry (IHC)
MPN Standard Reflex Panel Sequential testing panel including qualitative detection of JAK2 V617F, JAK2 Exon 12-14, and MPL exon 10. Testing proceeds by reflex through the three-step panel until a mutation is identified, when…
Molecular
Multiple Myeloma-MGUS FISH Panel (New York) Probes: 1p-, 1q+, iso(1q): CDKN2C (1p32), CKS1B (1q21) | +3, hyperdiploidy (Cen 3) | +5, hyperdiploidy (5p15.2, 5q33-34) | +9, hyperdiploidy (Cen 9) | 13q- (13q14, 13q34) | IgH (14q32) | p53 (17p-)…
FISH
p53 The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results in inactivation of its tumor suppressor function…
Immunohistochemistry (IHC)
p57 p57 (Kip 2, CDKN 1C) is an inhibitor of several G1 cyclin complexes and is a negative regulator of cell proliferation. The gene encoding human p57 is located on chromosome 11p15.5, a region…
Immunohistochemistry (IHC)
p63 p63 is a homologue of the p53 gene and is necessary for normal breast and prostate development. Unlike other markers of myoepithelial cells and basal cells, p63 immunoreactivity is localized to the…
Immunohistochemistry (IHC)
pAKT (Phosphorylated AKT) AKT is a signal transduction protein that plays a central role in inhibiting apoptosis in a variety of tumor types. Constitutive activation of AKT (phosphorylated) has been observed in several human…
Immunohistochemistry (IHC)
Pan Melanoma (S100 + Melan A + Tyrosinase) The Pan Melanoma staining combination increases sensitivity for melanomas. Since many skin biopsies are small, the triple stain conserves valuable tissue while saving time. Melan A (brown cytoplasmic…
Immunohistochemistry (IHC)
Pan Melanoma/Ki67 Pan Melanoma/Ki67 serves as a tool to identify the proliferation rate of melanocytic lesions. A high Ki67 rate of a melanocytic lesion raises the possibility of malignancy.
Immunohistochemistry (IHC)
Parvovirus This monoclonal antibody clone, R92F6, recognizes a capsid protein of human parvovirus B19. Therefore, this antibody will be useful in detection of parvovirus infected cells.
Immunohistochemistry (IHC)
PAX2 Paired Box 2 (PAX2) is a transcription factor that is essential for kidney development. In kidneys of normal adult, Pax2 protein expression is limited to nuclei of collecting ducts and to a lesser…
Immunohistochemistry (IHC)
PAX5 Paired Box 5 (PAX5) is a B-cell specific activator protein (BSAP). In early stages of B-cell development, PAX5 influences the expression of several B-cell specific genes, such as CD19 and CD20. PAX5…
Immunohistochemistry (IHC)
PAX8 The PAX8 gene is a member of the paired box (PAX) family of transcription factors. This family plays critical roles during fetal development and cancer growth. PAX8 is involved in kidney cell…
Immunohistochemistry (IHC)
PD1 Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm.…
Immunohistochemistry (IHC)
PD-L1 28-8 FDA (OPDIVO®) PD-L1 IHC 28-8 pharmDx is a qualitative immunohistochemical assay using Monoclonal Rabbit Anti-PD-L1, clone 28-8 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-…
Immunohistochemistry (IHC)
Plasma Cell Myeloma Prognostic FISH Panel (New York) Probes: 1p-, 1q+, iso(1q): CDKN2C (1p32), CKS1B (1q21) | FGFR3/IgH t(4;14) | CCND1/IgH t(11;14) | 13q- (13q14, 13q34) | IgH/MAF t(14;16) | 17p- (TP53 17p13.1, Cen 17) | Probes for each rearrangement…
FISH
Perforin Perforin is a protein found in cytoplasmic granules of cytotoxic T-lymphocytes (CTLs). CTLs bind to cells that express foreign antigens and induce them to lyse. Perforin expression is significantly…
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
PgR Progesterone Receptor (PR) belongs to a superfamily of nuclear hormone receptors. Estrogen Receptor (ER) induces PR expression, therefore, PR status serves as an indicator of an intact ER pathway.…
Immunohistochemistry (IHC)
pHistone H3 (PHH3) Phosphohistone H3 (PHH3) is a marker of cells in the late G2-M phase of the cell cycle. It is not expressed in apoptotic cells which may be confused with mitotic figures on a routine H&E stained…
Immunohistochemistry (IHC)
PLAP Normally human Placental Alkaline Phosphatase (PLAP) is produced by syncytiotrophoblasts after the twelfth week of pregnancy. PLAP is expressed by both malignant somatic and germ cell tumors. PLAP…
Immunohistochemistry (IHC)
PMS2 PMS2, also known as PMS1 protein homologue 2, is a DNA mismatch repair (MMR) protein. The PMS2 protein forms a heterodimer with the MLH1 protein which is then activated in the presence of ATP; this…
Immunohistochemistry (IHC)
Pneumocystis Carinii ( Jiroveci) This antibody is specific to P. carinii (P. Jiroveci). It stains P. carinii distinctly. The staining pattern is visualized as homogeneous rings corresponding to individual cyst walls. In addition,…
Immunohistochemistry (IHC)
Prealbumin (TTR) Prealbumin (Transthyretin, TTR) is a hormone-binding protein that participates in the plasma transport of both thyroxine and retinol (vitamin A). The vast majority are inherited in an autosomal…
Immunohistochemistry (IHC)
Multiple Myeloma IgH Complex FISH Panel (New York) Probes: FGFR3/IgH t(4;14) | CCND1/IgH t(11;14) | IgH/MAF t(14;16) | Probes for each translocation may be ordered separately.                      Disease(s): Plasma cell myeloma, multiple myelomaNote…
FISH
Plasma Cell Myeloma IgH Complex FISH Panel (non-New York) Probes: FGFR3/IgH t(4;14) | CCND1/IgH t(11;14) | IgH/MAF t(14;16) | IgH/MAFB t(14;20) Probes for each translocation may be ordered separately.  This panel is available separately or by reflex after…
FISH
CXCL13 CXCL13 is useful marker in the diagnosis of angioimmunoblastic T-cell lymphoma
Immunohistochemistry (IHC)
RHOA Mutation Analysis Bi-directional sequencing of the gene RHOA. The locked nucleic acid (LNA) technique is used to increase detection sensitivity for the G17V mutation. Note - Available as stand-alone or as part of the…
Molecular
NeoTYPE® Head & Neck Tumor Profile The NeoTYPE Head & Neck Tumor Profile analyzes 30 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include…
Molecular
PTEN Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene that is mutated in a wide range of cancers. PTEN plays a role in cell proliferation, apoptosis and migration. Reduced expression of…
Immunohistochemistry (IHC)
HPV DNA Tissue Testing HPV DNA Tissue Testing is peformed on FFPE tissue. It uses PCR and fragment analysis for qualitative detection and genotyping of human papillomavirus (HPV) low risk types 6/11 and high risk types 16…
Molecular
RB (Retinoblastoma Protein) Retinoblastoma (RB) is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. RB…
Immunohistochemistry (IHC)
NeoTYPE® AML Prognostic Profile This test is performed by sequencing the entire coding regions of the genes listed. ASXL1, BCOR, BRAF, CEBPA, CSF3R, DNMT3A, ETV6, EZH2, FLT3, HRAS, IDH1, IDH2, JAK2 including V617F and Exons 12+14,…
Molecular
Reticulin Special stain.
Immunohistochemistry (IHC)
AML Reflex Panel Routine cytogenetics with automatic addition of the NeoTYPE™ AML Prognostic Profile when cytogenetics results show intermediate risk including normal cytogenetics, +6, +8, -Y, or del(12p).
Molecular
S100 S100 belongs to the family of calcium binding proteins. Antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign melanocytic lesions, melanomas and their metastases. S100…
Immunohistochemistry (IHC)
inv(16), CBFB-MYH11 Translocation Real-time RT-PCR for quantitative detection of the inv(16) CBFB-MYH11 fusion transcript. Positive results are reported as ratio of the amount of fusion transcript with the amount of transcript from a…
Molecular
SALL4 SALL4, a newly identified zinc-finger transcriptional factor, is required for the maintenance of embryonic stem cell pluripotency by modulating OCT4. SALL4 is a novel sensitive and highly specific…
Immunohistochemistry (IHC)
SAT B2 SATB2 stains colonic and osteogenic cells and their neoplasms.
Immunohistochemistry (IHC)
Chromosome Analysis A wide variety of abnormalities can be identified, providing both diagnostic and prognostic information. Acute leukemias, lymphomas and chronic myeloid and lymphoid disorders are examined…
Cytogenetics
NeoARRAY™ SNP/Cytogenetic Profile The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage available, this test employs an enhanced SNP…
Cytogenetics
1p/19q Deletions for Glioma Probes: 1p36/1q25 |19q13/19p13Disease(s): Oligodendroglioma Ratios of p:q signals are determined for each chromosome to account for sectioning artifact. Deletion status is reported for each…
FISH
ALK for Lymphoma Probes: ALK (2p23)Disease(s): Anaplastic large cell lymphoma, NHL
FISH
ALK for NSCLC Probes: ALK (2p23)Disease(s): Non-small cell lung carcinoma (NSCLC)
FISH
ALL Adult FISH Panel Probes: TCF3/PBX1 (E2A/PBX1) t(1;19) | Trisomy or Tetrasomy 4, 6, 10, 17 (Cen 4, Cen 6, Cen 10, Cen 17) | MYC (8q24) | BCR/ABL1/ASS1 t(9;22) | MLL (11q23) | IgH (14q32) |Disease(s): Acute…
FISH
ALL Pediatric FISH Panel Probes: TCF3/PBX1 (E2A/PBX1) t(1;19) | Trisomy or Tetrasomy 4, 6, 10, 17 (Cen 4, Cen 6, Cen 10, Cen 17) | MYC (8q24) | BCR/ABL1/ASS1 t(9;22) | MLL (11q23) | ETV6/RUNX1 (TEL/AML1) t(12;21) | IgH (…
FISH
AML Favorable-Risk Panel Probes: RUNX1/RUNX1T1 (ETO/AML1) t(8;21) | PML/RARA t(15;17) | CBFB inv(16), t(16;16)Disease(s): Acute myeloid leukemia Probes may be ordered separately.
FISH
AML FISH Panel (New York) Probes: 5q-, -5 (5p15.2, 5q33-34) | 7q-, -7 (7q31, Cen 7) | Trisomy 8 (Cen 8) | MLL (11q23) | RUNX1T1/RUNX1 (ETO/AML1) t(8;21) | PML/RARA t(15;17) | CBFB inv(16), t(16;16) Probes may be ordered…
FISH
AML Non-Favorable Risk FISH Panel Probes: RPN1, MECOM (3q21, 3q26.2) | 5q-, -5 (5p15, 5q31, 5q33 | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | DEK/NUP214 (CAN) t(6;9) | MLL (11q23) | ETV6 (12p13) | 17p- (TP53 17p13.1, NF1 17q11…
FISH
AML Standard FISH Panel Probes: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | 20q- (20q12, 20qter) | RUNX1/RUNX1T1 (ETO/AML1) t(8;21) | PML/RARA t(15;17) | CBFB inv(16), t(16;…
FISH
API2/MALT1 t(11;18) Probes: API2/MALT1 t(11;18)Disease(s): MALT lymphoma, NHL
FISH
BCL2 Probes: BCL2 (18q21)Disease(s): B-cell lymphoma, non-Hodgkin lympoma (NHL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL)
FISH
BCL6 (3q27) Probes: BCL6 (3q27)Disease(s): Diffuse large B-cell lymphoma, NHL
FISH
BCR/ABL1 t(9;22) Probes: ABL1 (9q34); ASS1 (9q34; BCR (22q11.2)Disease(s): CML, ALL, MPNNote: For suspected ALL, STAT processing is available by request. Note STAT along with MD contact name and phone number to…
FISH
Bladder Cancer Probes: +3 (Cen 3) | +7 (Cen 7) | p16 (9p21) | +17 (Cen 17)Disease(s): Bladder cancer
FISH
BRAF Rearrangement Probes: BRAF (7q34)Disease(s): Brain cancer, thyroid cancer, melanoma
FISH
CBFB inv(16) Probes: CBFB inv(16), t(16;16)Disease(s): AML, AMML (AML-M4E)
FISH
CCND1(BCL1)/IgH t(11;14) Probes: CCND1/IgH t(11;14)Disease(s): Mantle cell lymphoma, NHL
FISH
Centromere 1 FISH for POC Ploidy Probes: CEN 1 (1p11.1-q11.1)Disease(s): Molar pregnancy vs. partial mole This test is currently available on a global basis only.
FISH
CLL FISH Panel Probes: 6q- [SEC63 (6q21), MYB (6q23)] | ATM (11q22.3) | p53 (17p13.1) | Trisomy 12 (Cen 12) | 13q-/-13 (13q14, 13q34) | CCND1/IgH t(11;14) | Probes may be ordered separately (except 12 and 13 are…
FISH
DDIT3 (CHOP) Probes: DDIT3 (CHOP) (12q13)Disease(s): Myxoid-round cell liposarcoma (M/RCLS)
FISH
EGFR Amplification Probes: EGFR (7p11.2) | Centromere 7Disease(s): Brain, lung, colorectal, gastric, breast cancers
FISH
Eosinophilia FISH Panel Probes: PDGFRa, CHIC2, FIP1L1 (4q12) | PDGFRb (5q33) | FGFR1 (8p11) | CBFB inv(16), t(16;16) | Probes may be ordered separately.Disease(s): Lymphoid and myeloid neoplasms with eosinophilia, including…
FISH
EWSR1 Probes: EWSR1 (22q12)Disease(s): Ewing sarcoma, primitive neuroectodermal tumor (PNET)
FISH
FGFR3/IgH t(4;14) Probes: FGFR3/IgH t(4;14)Disease(s): Multiple myeloma, MGUS
FISH
HER2 Breast Cancer Probes: HER2 (17q11.2-q12) | 17 (Cen 17Disease(s): Breast cancer
FISH
HER2 Gastric & Non-Breast Probes: HER2 (17q11.2-q12) | 17 (Cen 17)Disease(s): Gastric cancer, gastroesophageal junction (GEJ) cancer, esophageal adenocarcinoma, and others
FISH
High-Grade/Large B-Cell Lymphoma Panel (NY and non-NY) Probes: BCL6 (3q27) | MYC (8q24) | IgH/BCL2 t(14;18) | Optional probes: MYC/IgH/CEN8 t(8;14) [available to all clients] and BCL2 (18q21) [non-New York clients only]Disease(s): B-cell lymphoma,…
FISH
IgH (14q32) Probes: IgH (14q32)Disease(s): Lymphoma, NHL, multiple myeloma, MGUS
FISH
IgH/BCL2 t(14;18) Probes: IgH/BCL2 t(14;18)Disease(s): Follicular lymphoma, NHL
FISH
IgH/MAF t(14;16) Probes: IgH/MAF t(14;16)Disease(s): Multiple myeloma, MGUS
FISH
IgH/MAFB t(14;20) Probes: IgH/MAFB t(14;20) This probe combination may be ordered separately or added to any of our mye Disease(s): Myeloma, MGUSloma FISH panels.
FISH
MALT1 (18q21) Probes: MALT1 (18q21)Disease(s): Marginal zone B-cell lymphoma, NHL
FISH
MDM2 Probes: MDM2 (12q15) | Centromere 12Disease(s): Liposarcoma
FISH
MDS Extended FISH Panel Probes: RPN1, MECOM (3q21, 3q26.2) | 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | ETV6 (12p13) | 17p- (TP53 17p13.1, NF1 17q11.2) | +19 (19p13.2, 19q13…
FISH
MDS Standard FISH Panel Probes: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | 20q- (20q12, 20qter) Probes may be ordered separately except +8 and 20q- which are combined.…
FISH
MET FISH Probes: MET (7q31) | Centromere 7Disease(s): Multiple solid tumor cancers including lung (NSCLC), gastric, esophageal, endometrial
FISH
MLL (11q23) Probes: MLL (11q23)Disease(s): ALL, AML
FISH
MPN FISH Panel Probes: PDGFRa, CHIC2, FIP1L1 (4q12) | PDGFRb (5q33) | FGFR1 (8p11) | BCR/ABL1 t(9;22) including ASS1 (9q34) | Probes may be ordered separately.Disease(s): Myeloproliferative neoplasms
FISH
Plasma Cell Myeloma FISH Panel (non-New York) Probes: 1p-, 1q+, iso(1q): CDKN2C (1p32), CKS1B (1q21) | +5, hyperdiploidy (5p15) | +9, hyperdiploidy (9q22) | +15, hyperdiploidy (15q22) | 13q- (13q14, 13q34) | IgH (14q32) | 17p- (TP53 17p13.1, NF1…
FISH
MYC (8q24) Probes: MYC (8q24)Disease(s): Lymphoma, NHL, B-ALL
FISH
MYC/IgH/Cen 8 t(8;14) Probes: Trisomy 8 (Cen 8) | MYC/IgH t(8;14)Disease(s): Burkitt lymphoma, NHL
FISH
MYCN (n-MYC) Amplification Probes: MYCN (2p24.3) | Centromere 2Disease(s): Brain cancer, neuroblastoma, alveolar rhabdomyosarcoma, small-cell lung cancer, prostate cancer.
FISH
NeoSITE™ BE Barrett's Esophagus FISH Panel Probes: MYC (8q24) | p16 (CDKN2A at 9p21) | HER2 (ERBB2 at 17q12) | ZNF217 (20q13) This 4-probe FISH assay is performed on cytology brushings from Barrett esophagus to determine patterns of…
FISH
NeoSITE™ Cervical FISH Panel Probes: TERC (3q26) | D5S630 (5p15) |CEN 7 (7p11.1-q11.1) | MYC (8q24) | ZNF217 (20q13)Disease(s): Cervical neoplasia, ASCUS, LSIL, HSIL, CIN, cervical cancer
FISH
NeoSITE™ Melanoma Probes: RREB1 (6p25) | MYC (8q24) | CDKN2A p16 (9p21) | Centromere 9 | CCND1 (11q13)Disease(s): MelanomaRead more about the NeoSITE Melanoma panel.
FISH
Non-Hodgkin's Lymphoma (NHL) FISH Panel Probes: ALK (2p23) | BCL6 (3q27) | MYC (8q24) | CCND1/IgH t(11;14) | IgH (14q32) | IgH/BCL2 t(14;18) | MALT1 (18q21) Probes may be ordered separately.Disease(s): NHL
FISH
PDGFRA Amplification Probes: PDGFRA (4q12) | Centromere 4Disease(s): Brain cancer
FISH
HepPar1 Anti-Hepatocyte Specific Antigen (HepPar1) recognizes both benign and malignant liver derived tumors such as hepatoblastoma, hepatocellular carcinoma and hepatic adenoma. It recognizes both adult and…
Immunohistochemistry (IHC)
IgA IgA antibody reacts with immunoglobulin Ig alpha chains. It is useful in identifying leukemias, plasmacytomas and B-cell lineage lymphomas.
Immunohistochemistry (IHC)
IgD IgD antibody reacts with immunoglobulin Ig delta chains. This antibody is useful when identifying leukemias, plasmacytomas and B-cell lineage lymphomas (in particular marginal zone lymphoma).…
Immunohistochemistry (IHC)
IgG IgG antibody reacts with immunoglobulin Ig gamma chains. This antibody may be useful in identifying plasma cytomas and B-cell lineage lymphomas, and in conjunction with IgG4 staining to assess for…
Immunohistochemistry (IHC)
IgG4 (Immunoglobulin G4) Autoimmune pancreatitis typically produces an enlarged pancreas with narrowing of the pancreatic duct, and can mimic carcinoma. It was shown that the pancreatic tissue from patients with autoimmune…
Immunohistochemistry (IHC)
IgM IgM antibody reacts with immunoglobulin Ig mu chains. This antibody is useful when identifying leukemias, plasmacytomas and B-cell lineage lymphomas.
Immunohistochemistry (IHC)
Glucagon Glucagon antibody is used for the identification of tumors and hyperplasias of pancreatic islets. This antibody labels A cells of the endocrine mammalian pancreas. It reacts with glucagon in a large…
Immunohistochemistry (IHC)
OCT2 Octamer Binding Transcription Factor 2 (OCT2) is present in all B-cells expressing Ig. The combination of BOB1 and OCT2 stains is helpful in distinguishing between classical Hodgkin lymphoma (at…
Immunohistochemistry (IHC)
Kappa Antibody to the kappa light chain of immunoglobulin is reportedly useful in the identification of leukemias, plasmacytomas and certain non-Hodgkin lymphomas. Demonstration of monotypism in lymphoid…
Immunohistochemistry (IHC)
Ki67 Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases of the cell cycle, while cells in the G0 (quiescent) phase are…
Immunohistochemistry (IHC)
Lambda (Lambda Light Chain IgG) by IHC Antibody to the lambda light chain of immunoglobulin is reportedly useful in the identification of leukemias, plasmacytomas and certain non-Hodgkin lymphomas. Demonstration of monotypism in lymphoid…
Immunohistochemistry (IHC)
Langerin Langerin is a highly selective marker for Langerhans cells and the lesional cells of Langerhans cell histiocytosis. Langerin protein expression has utility in differentiating Langerhans cell…
Immunohistochemistry (IHC)
LEF1 LEF1 overexpression is highly associated with CLL/SLL among small B-cell lymphomas and may serve as a useful marker for diagnosis and differential diagnosis of the disease.
Immunohistochemistry (IHC)
LMO2 LMO2 protein is expressed in normal human germinal-center (GC) and GC-derived lymphomas. In addition, it is also expressed at high levels in endothelial cells, spleen, hematopoietic precursors, and a…
Immunohistochemistry (IHC)
Lysozyme Lysozyme is synthesized predominantly in reactive histiocytes rather than in resting, unstimulated phagocytes. This antibody labels myeloid cells, histiocytes, granulocytes, macrophages and monocytes…
Immunohistochemistry (IHC)
NeoLAB™ MDS/CMML Profile - Liquid Biopsy This test is performed by the sequencing the entire coding regions of the genes listed using cell-free plasma DNA/RNA. ASXL1, BCOR, BCORL1, BRAF, CBL, CEBPA, CUX1, DNMT3A, ETV6, EZH2, FLT3, HRAS,…
Molecular
Masson Trichrome Special stain.
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Melan A (Mart1) Melan A (Mart1, Melanoma Antigen Recognized by T-cells 1), is a differentiation antigen that is expressed in melanocytes, most melanomas. Melan A recognizes a subcellular fraction found in…
Immunohistochemistry (IHC)
Mesothelin Mesothelin is a 40kDa cell surface glycoprotein selectively expressed by mesothelial cells and malignant mesotheliomas, as well as by non-mucinous ovarian carcinomas, breast carcinomas, pancreatic…
Immunohistochemistry (IHC)
MGMT MGMT (O-6-methylguanine-DNA methyltransferase) is a DNA repair enzyme. MGMT protects cells from alkylating toxins, and is an important factor in drug resistance to alkylating therapeutic agents. It…
Immunohistochemistry (IHC)
MITF MITF (microphthalmia transcription factor) is a transcription factor that regulates the development and survival of melanocytes. MITF is restricted to the melanocyte cell lineage. Anti-MITF…
Immunohistochemistry (IHC)
MDS FISH Panel (New York) Probes: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (7q31, Cen 7) | Trisomy 8 (Cen 8) | MLL (11q23) | 20q- (20q12, 20qter) Probes may be ordered separately except +8 and 20q- which are combined.Disease(s):…
FISH
MMR Panel by IHC (MLH1, MSH2, MSH6, PMS2) A well-defined subtype of colorectal cancer (CRC) is characterized by deficiencies in the mismatch repair (MMR) pathway. MMR status may impact prognosis and benefit of adjuvant chemotherapy. MLH1,…
Immunohistochemistry (IHC)
MOC31 Monoclonal antibody MOC31 recognizes a membrane glycoprotein of 40kDa present on epithelial cells but not on mesothelial cells. MOC31 reacts with most adenocarcinomas of various origins, typically…
Immunohistochemistry (IHC)
MPO Myeloperoxidase (MPO) is an important enzyme used by granulocytes during phagocytic lysis of engulfed foreign particles. In normal tissues and in a variety of myeloproliferative disorders, myeloid…
Immunohistochemistry (IHC)
TPMT Genotyping This PCR-based allele discrimination assay is performed on genomic DNA and detects the four most common abnormal alleles of the thiopurine methyltransferase (TPMT) gene, which are TPMT*2 (238G>C…
Molecular
DNA Ploidy/Cell Cycle Analysis – Heme Available as a global test only. DNA stain is DRAQ5™ to determine S-phase cell cycle fraction and DNA index as indicators of DNA ploidy in fresh leukemia or lymphoma specimens. Two markers will be…
Flow Cytometry
MUC1 Mucin 1 (MUC1) is a high molecular weight glycoprotein that is found on the apical surface of many glandular epithelia, including the gastrointestinal, respiratory, urinary, reproductive tracts and…
Immunohistochemistry (IHC)
MUC2 Mucin 2 (MUC2) expression is detected in human tissues such as normal colon, breast, prostate, and salivary gland, as well as in gastrointestinal, colonic, breast and prostate neoplasia. This…
Immunohistochemistry (IHC)
MUC5 Mucin 5 (MUC5) is expressed in gastric mucosa, and in gall bladder epithelium. MUC5 antibody is recommended for use as part of a panel of antibodies for the characterization of mucin expression and…
Immunohistochemistry (IHC)
CDKN2A (p16) Deletion FISH for ALL Probes: CDKN2A (p16) (9p21) | Centromere 9Disease(s): Acute Lymphoblastic Leukemia (ALL)
FISH
Mucicarmine Special stain. Mucicarmine staining is used to identify epithelial mucins, namely acid mucopolysaccharides. Staining is useful to distinguishing mucin negative undifferentiated squamous cell lesions…
Immunohistochemistry (IHC)
MUM1 The MUM1 antibody is specific for the MUM1/IRF4 protein that is overexpressed in late plasma-cell-directed stages of B-cell differentiation. MUM1 is a powerful tool for understanding the histogenesis…
Immunohistochemistry (IHC)
MPO Cytochemical Cytochemical stain. Myeloperoxidase (MPO) is present in granules of myeloid and monocytic cells, but absent from lymphocytes. Therefore MPO is an important marker for discriminating myeloid vs.…
Immunohistochemistry (IHC)
MyoD1 Nuclear expression of myogenic differentiation 1 (MyoD1) is restricted to skeletal muscle tissue and has been demonstrated to be a sensitive marker of myogenic differentiation. The antibody strongly…
Immunohistochemistry (IHC)
Myogenin Expression of myogenin is restricted to cells of skeletal muscle origin. It is a useful marker for tumors of the muscle lineage, being strongly expressed in alveolar rhabdomyosarcomas.
Immunohistochemistry (IHC)
Myoglobin Myoglobin is found in skeletal and cardiac muscle but not in smooth muscle. Because myoglobin appears relatively late in the maturational sequence of striated muscle, it is typically undetectable…
Immunohistochemistry (IHC)
NeoTYPE® MPN Profile This test is performed by sequencing the entire coding regions of the genes listed unless another method is noted. ABL1, ASXL1, BRAF, CALR, CEBPA, CSF3R, EZH2, FLT3, HRAS, IDH1, IDH2, JAK2 including…
Molecular
CALR Mutation Analysis Bi-directional sequencing of exon 9 of the CALR (calreticulin) gene with fragment length analysis for enhanced detection of low levels of insertion/deletion mutations.Testing is approved for…
Molecular
NF (Neurofilament) Neurofilaments (NFs) are the intermediate filaments of neurons and their processes. NFs are expressed in tumors of neural origin or tumors displaying neuronal differentiation, such as neuroblastoma,…
Immunohistochemistry (IHC)
NKX2.2 Homeobox protein NKX2.2 plays a critical role in neuroendocrine/glial differentiation. The NKX2.2 gene was recently identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma.…
Immunohistochemistry (IHC)
CSF3R Mutation Analysis Bi-directional sequencing of exons 14 and 17 of the CSF3R gene which includes detection of the common mutation T618I (also known as T595I).
Molecular
NSE (Neuron Specific Enolase) In normal tissue, most neurons and their axonal and dendritic processes stain strongly positive for Neuron Specific Enolase (NSE), with the exception of Purkinje cells. Schwann cells, cells of the…
Immunohistochemistry (IHC)
JAK2 Exon 12-14 Mutation Analysis RT-PCR and bi-directional sequencing to detect non-V617F mutations in exons 12-14 and most of exon 15, corresponding to the majority of the JAK2 pseudokinase domain. Exon deletion mutations are…
Molecular
PDGFRA Rearrangement Probes: PDGFRA | CHIC2 | FIP1L1 (4q12) Disease(s): Chronic eosinophilic leukemia, MPN
FISH
PML/RARA t(15;17) Probes: PML/RARA t(15;17)Disease(s): AML, APL (AML-M3)Note: PML-RARA FISH is performed STAT when ordered as a stand-alone test (outside a panel). Note MD contact name and phone number to receive STAT…
FISH
PTEN Probes: PTEN (10q23) | GRID1 (10q23.2) | Centromere 10Disease(s): Prostate cancer, melanoma, squamous cell carcinoma of the head and neck (PTEN deletions) This test may be ordered separately or as…
FISH
RARA Break-Apart Disease(s): APL, AMLProbes: RARA (17q21)
FISH
RET FISH Probes: RET (10q11.2)Disease(s): Lung cancer, thyroid cancer
FISH
ROS1 Probes: ROS1 (6q22.1)Disease(s): Non-small cell lung carcinoma (NSCLC)
FISH
RUNX1T1/RUNX1 (ETO/AML1) t(8;21) Probes: RUNX1T1/RUNX1 (ETO/AML1) t(8;21)Disease(s): AML-M2
FISH
SS18 (SYT) Probes: SS18 (SYT) (18q11.2)Disease(s): Synovial sarcoma
FISH
TCL1 Probes: TCL1 (14q32.1)Disease(s): mature T-cell leukemia, T-cell prolymphocytic leukemia (T-PLL), adult T-cell leukemia/lymphoma (ATLL)
FISH
X/Y FISH for Engraftment Probes: Centromere X | DYZ1Disease(s): Sex-mismatched stem cell transplant
FISH
AML Follow-Up Flow Panel Available as global and tech-only. Please provide clinical history including the time after treatment. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly…
Flow Cytometry
B-ALL Follow-Up Flow Panel Available only as tech-only. Global clients, please refer to the B-ALL MRD Flow Panel. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly recommended. Tech-only…
Flow Cytometry
B-Cell Lymphoma Follow-Up Flow Panel Available as global and tech-only. Please provide clinical history including the time after treatment. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly…
Flow Cytometry
T-Cell Therapy Flow Panel Available as global and tech-only. Available as stand-alone test (as described here) or as add-on to panels. Markers are CD3, CD4, CD7, CD8, CD25, CD26, CD30, CD45, CD52, and CD279 (10 markers).
Flow Cytometry
DNA Ploidy/Cell Cycle Analysis – POC/Solid Tumors Available as a global test only. DNA stain propidium iodide (PI) is used to determine S-phase cell cycle fraction and DNA index as indicators of DNA ploidy. Products of conception (POC) and solid…
Flow Cytometry
Extended Leukemia/Lymphoma Panel - 31 markers Available as global and tech-only. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11b, CD11c, CD13, CD14, CD15, CD16, CD19, CD20, CD23, CD33, CD34, CD38, CD41, CD45, CD56, CD64, CD71, CD117, CD138…
Flow Cytometry
Hairy Cell Leukemia (HCL) Follow-Up Flow Panel Available as global and tech-only. Please provide clinical history including the time after treatment. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly…
Flow Cytometry
High Sensitivity PNH Evaluation Markers are CD14, CD15, CD24, CD45, CD59, CD64, CD235a (Glycophorin A), and FLAER. In validation studies, this assay was shown to detect RBC and granulocyte PNH clones with frequency down to 0.01%.
Flow Cytometry
Plasma Cell Follow-Up Flow Panel Available as global and tech-only. Please provide clinical history including the time after treatment. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly…
Flow Cytometry
Standard Leukemia/Lymphoma Panel - 24 markers Available as global and tech-only. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD13, CD14, CD16, CD19, CD20, CD23, CD33, CD34, CD38, CD45, CD56, CD64, CD117, HLA-DR, kappa, and lambda.
Flow Cytometry
T-ALL Follow-Up Flow Panel Available as global and tech-only. Please provide clinical history including the time after treatment. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly…
Flow Cytometry
T-Cell Lymphoma Follow-Up Flow Panel Available as global and tech-only. Please provide clinical history including the time after treatment. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly…
Flow Cytometry
V-Beta T-Cell Clonality Available as global test only. Markers are VB1, VB2, VB3, VB4, VB5.1, VB5.2, VB5.3, VB7.1, VB7.2, VB8, VB9, VB11, VB12, VB13.1, VB13.2, VB13.6, VB14, VB16, VB17, VB18, VB20, VB21.3, VB22, and VB23 (…
Flow Cytometry
ZAP-70 Lymphoid Panel Available as global and tech-only. Markers are CD3, CD5, CD19, CD45, and ZAP-70.
Flow Cytometry
AML Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
B-ALL Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
Erythroid-Mega Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
Hairy Cell Leukemia (HCL) Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
T-Cell Receptor/LGL Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
Mast Cell Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
Hematogone Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
Monocyte Maturation Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
MDS Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
Pan-TRK Pan-TRK (clone EPR17341) is directed against the C-terminal region of TRK (tropomyosin receptor kinase) A, B, and C proteins, which are encoded by NTRK1, NTRK2, and NTRK3 genes respectively.  Pan-TRK…
Immunohistochemistry (IHC)
AAT Alpha-1-Antitrypsin (AAT) is useful in the study of inherited AAT deficiency, benign and malignant hepatic tumors and yolk sac carcinoma. Sensitivity and specificity of the results have made this…
Immunohistochemistry (IHC)
AFB Special stain. Ziehl-Neelsen Acid-Fast Bacilli Stain is used to detect the presence of acid-fast mycobacteria in tissue sections. Acid-fast techniques are of value in the detection of mycobacteria,…
Immunohistochemistry (IHC)
Acid Phosphatase (AcP) Cytochemical stain.
Immunohistochemistry (IHC)
ACTH Anti-adrenocorticotropic hormone (ACTH) is a useful marker in the classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also…
Immunohistochemistry (IHC)
MSA Muscle Specific Actin (MSA) antibody recognizes the alpha and gamma isotypes of skeletal, cardiac, and smooth muscle cells. It is non-reactive with other mesenchymal cells and all epithelial cells…
Immunohistochemistry (IHC)
SMA Smooth muscle actin antibody binds to smooth muscle cells and myoepithelial cells. It stains the muscularis propria and muscularis mucosae of the gastrointestinal tract, the uterine myometrium,…
Immunohistochemistry (IHC)
Adenovirus Adenoviruses are simple DNA-containing viruses that multiply in the cell nucleus. They induce latent infections in tonsils, adenoids and other lymphoid tissue of man, causing either unapparent or…
Immunohistochemistry (IHC)
AFP Alpha-1-fetoprotein (AFP) is a 64 kD tumor-associated embryonal antigen produced by fetal liver, hepatocellular carcinoma, yolk sac tumor and several germ cell tumors of testicular and ovarian origin…
Immunohistochemistry (IHC)
Alcian Blue Special stain. Alcian blue is intended to identify weakly sulfated mucins in tissue samples.
Immunohistochemistry (IHC)
ALK (D5F3) VENTANA FDA approved ALK (D5F3) CDx Assay is intended for the qualitative detection of the anaplastic lymphoma kinase (ALK) protein in formalin-fixed, paraffin-embedded (FFPE) non-small cell lung…
Immunohistochemistry (IHC)
ALK-1 (for heme cases) The ALK1 (ALK1 cline) antibody labels normal human ALK protein and the NPM-ALK chimeric protein, and is a useful tool for the identification of the subgroup of anaplastic large-cell lymphomas (ALCL)…
Immunohistochemistry (IHC)
Annexin A1 Annexin A1 (ANXA1), a gene related to phagocytosis, is found to be one of the most highly upregulated genes in hairy cell leukemia. Annexin A1 is strongly expressed on the cell membrane of 97% of…
Immunohistochemistry (IHC)
AR Androgen receptor (AR) is responsible for the regulation of the growth of the prostate epithelial cells. In untreated prostate carcinoma, AR positive cells are more likely to be responsive to…
Immunohistochemistry (IHC)
Arginase 1 Arginase 1 (ARG1), also known as liver arginase, is a binuclear manganese metalloenzyme. ARG1 is abundantly expressed in liver and represents a sensitive and specific marker of benign and malignant…
Immunohistochemistry (IHC)
B72.3 This monoclonal antibody (B72.3) to tumor-associated glycoprotein recognizes a tumor-associated oncofetal antigen (TAG-72) expressed by a wide variety of human adenocarcinomas. This antigen is…
Immunohistochemistry (IHC)
BCA-225 This antibody recognizes a human breast carcinoma associated glycoprotein BCA-225 (220-225kD). This protein differs in size and distribution from other breast carcinoma antigens. It does not react…
Immunohistochemistry (IHC)
BCL1/Cyclin D1 BCL1/Cyclin D1 is a nuclear protein detectable in formalin-fixed, paraffin-embedded (FFPE) sections and is found in the majority of mantle cell lymphomas. Hairy cell leukemia and plasmacytoma may…
Immunohistochemistry (IHC)
BCL2 B-cell lymphoma 2 (BCL2) was the first of the translocation-associated proteins to be identified in lymphoma. Most cases of follicular lymphoma have a [t(14;18)] translocation, resulting in BCL2…
Immunohistochemistry (IHC)
BCL6 BCL6 antibody stains the germinal center cells in lymphoid follicles, the follicular cells and interfollicular cells in follicular lymphoma, a subset of diffuse large B-cell lymphomas, and Burkitt…
Immunohistochemistry (IHC)
BerEP4 Ber-EP4 recognizes two glycoproteins of 34 and 49 kDa present on the surface and the cytoplasm of all epithelial cells except the superficial layers of squamous epithelial, hepatocytes and parietal…
Immunohistochemistry (IHC)
Beta Catenin Beta-catenin is an important regulator of cell–cell adhesion and embryogenesis. Mutations of beta-catenin could lead to some human cancers. Normal cells show membrane staining for beta-catenin, while…
Immunohistochemistry (IHC)
BG8 This antibody is specific for the Lewis Y (Type 2 Chain) carbohydrate antigen. Lewis Y has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular…
Immunohistochemistry (IHC)
BOB1 BOB1 is present in all B-cells expressing Ig. The combination of BOB1 and OCT2 staining is helpful in distinguishing between classical Hodgkin lymphoma (at least one marker negative) and nodular…
Immunohistochemistry (IHC)
BRAF V600E A monoclonal antibody (VE1) against mutant BRAF (V600E) permits fast assessment of the mutant protein expression throughout a tumor sample in hairy cell leukemia, some melanomas, and some thyroid…
Immunohistochemistry (IHC)
BRCA1 BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. This test detects expression…
Immunohistochemistry (IHC)
Breast Triple Stain (CK5 + p63 + CK 8/18) The combination of CK5 + P63 + CK8/18 (Breast Triple Stain) can be useful in distinguishing ductal carcinoma in situ (DCIS) from microinvasive breast carcinoma. This multiplex can decipher between a…
Immunohistochemistry (IHC)
CA125 CA125 reacts with most epithelial ovarian neoplasms of serous, endometrioid, clear cell and undifferentiated types. CA125 is a useful tumor marker for ovarian carcinomas; however, CA125 has also been…
Immunohistochemistry (IHC)
CA19.9 In normal tissues, the CA19.9 antigen has been demonstrated in ductal epithelium of the breast, kidney, salivary gland, sweat glands, respiratory epithelium of the lung, colon epithelium, pancreatic…
Immunohistochemistry (IHC)
Carbonic Anhydrase IX (CA IX) Carbonic anhydrase IX (CAIX) is a cell surface transmembrane protein, which is predominantly found in the gastrointestinal tract and gall bladder. The glandular regions of normal colon are reported…
Immunohistochemistry (IHC)
Calcitonin Calcitonin is secreted by thyroidal parafollicular cells of neuroectodermal origin, probably in response to hypercalcemia. The IHC demonstration of calcitonin is important: (1) For identification of…
Immunohistochemistry (IHC)
Calcium Stain Special stain.
Immunohistochemistry (IHC)
Caldesmon Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction. Two closely related variants of human caldesmon have been identified. The h-caldesmon variant (…
Immunohistochemistry (IHC)
Calponin Calponin, a calmodulin, is involved in the regulation of smooth muscle contraction. The expression of calponin is restricted to smooth muscle cells. Two isoforms of calponin exist with molecular…
Immunohistochemistry (IHC)
Calretinin Calretinin is the most specific and reproducible positive marker of epithelial mesothelioma. Calretinin is a calcium-binding protein similar to S100 protein. It is found in the central and peripheral…
Immunohistochemistry (IHC)
CD10 CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is expressed in early lymphoid progenitors and normal germinal center cells. It is almost always present on the surface of…
Immunohistochemistry (IHC)
CD117 cKIT CD117 (cKit) is a transmembrane receptor tyrosine kinase. It is expressed in many tissues and cells, such as tissue mast cells, skin basal cells, melanocytes, breast glandular epithelial cells,…
Immunohistochemistry (IHC)
CD11c In normal cells, CD11c is expressed on activated CD4/CD8+ T cells, granulocytes, lymphocytes, macrophages, and NK cells. In diseased, cells, CD11c is detected on acute myeloid leukemia (AML)-M4 and…
Immunohistochemistry (IHC)
CD123 CD123 labels plasmacytoid dendritic cells and is useful in diagnosing neoplasms derived from these cells as well as reactive conditions, such as histiocytic necrotizing lymphadentis.
Immunohistochemistry (IHC)
CD138 CD138 (Syndecan-1) positively stains normal tissue including B-cell precursors and plasma cells. Positive staining in tumors includes myeloma, primary effusion lymphoma. CD138 negative staining…
Immunohistochemistry (IHC)
CD14 CD14 stains normal macrophages/monocytes, granulocytes (weak), Langerhans cells, dendritic cells, and B cells. Positive staining in diseased cells comprises B-cell chronic lymphocytic leukemia (B-CLL…
Immunohistochemistry (IHC)
CD15 CD15 (X-Hapten) plays a role in mediating phagocytosis, bactericidal activity, and chemotaxis. It is present on granulocytes, including neutrophils and eosinophils, and to a lesser degree on…
Immunohistochemistry (IHC)
CD163 CD163 antigen is restricted in its expression to the monocytic/macrophage lineage. It is present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and…
Immunohistochemistry (IHC)
CD19 CD19 recognizes a 95kD cell surface glycoprotein which is expressed by cells of the B-cell lineage and follicular dendritic cells. CD19 is a co-receptor of CD21and is an important signal transduction…
Immunohistochemistry (IHC)
CD1a At least five CD1 genes (CD1a, b, c, d, and e) have been identified. CD1a is expressed on cortical thymocytes, Langerhans cells, and dendritic cells. It is absent on mature peripheral blood T-cells,…
Immunohistochemistry (IHC)
CD2 CD2, the E-rosette receptor, is an extremely broad T-cell marker. This antibody immunostains the vast majority of T-cells and a subset of natural killer (NK) - cell malignancies. Half of thymic B-…
Immunohistochemistry (IHC)
CD20 Normal cell expression of CD20 is found on most B-cells (after CD19 and CD10 expression, before CD21/22 expression and surface immunoglobulin expression) and expression is retained on mature B-cells…
Immunohistochemistry (IHC)
CD21 CD21 (CR2, C3d receptor and EBV receptor) is expressed strongly on mature B-cells, follicular dendritic cells (FDC) and weakly on immature thymocytes and T-lymphocytes. In B-cell ontogeny, CD21…
Immunohistochemistry (IHC)
CD22 CD22 expression is restricted to normal and neoplastic B-cells and is absent from other hemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B-cells…
Immunohistochemistry (IHC)
CD23 CD23 is identical to low affinity IgE receptor found on B-cells. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B-lymphoblastoid cell lines. CD23…
Immunohistochemistry (IHC)
CD25 The interleukin-2 receptor is designated CD25. Originally isolated from T-lymphocytes, it is now known to be expressed on hairy cell leukemia and adult T-cell leukemia/lymphoma, classical Hodgkin…
Immunohistochemistry (IHC)
CD3 The CD3 antigen is first detectable in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T-cell lineage. It has a cytoplasmic expression at early…
Immunohistochemistry (IHC)
CD30 CD30 is a lymphocyte activation antigen, related to tumor necrosis factor. It is expressed in activated B-, T- and NK cells. Positive staining is seen in infectious mononucleosis, lymphocytes…
Immunohistochemistry (IHC)
CD31 CD31 is a 130kDa transmembrane glycoprotein that is shared by vascular lining cells, megakaryocytes and platelets. This marker is highly restricted to endothelial neoplasms among all tumors of the…
Immunohistochemistry (IHC)
CD33 CD33 is a useful marker to identify cells of myeloid and monocytic lineage, leukemias and myeloproliferative neoplasms derived from these cells.
Immunohistochemistry (IHC)
CD34 CD34, a single chain transmembrane glycoprotein, is selectively expressed on human lymphoid and myeloid hematopoietic progenitor cells and endothelial cells. CD34 antibody labels many…
Immunohistochemistry (IHC)
CD35 CD35 antigen is a transmembrane protein of 160-250 kDa that binds complement components C3b and C4b. It mediates phagocytosis by neutrophils and monocytes. CD35 is found on erythrocytes, B-cells, a…
Immunohistochemistry (IHC)
CD38 CD38 is a transmembrane protein that is highly expressed on thymocytes. It is also present on activated T-cells and terminally differentiated B-cells (plasma cells). Other reactive cells include NK…
Immunohistochemistry (IHC)
CD4 CD4, a single chain transmembrane glycoprotein, is found on a T-cell subset (helper/inducer). It is also present on a variety of monocyte-derived cells, including Langerhans and other dendritic cells…
Immunohistochemistry (IHC)
CD42b CD42b stains normal platelets, megakaryocytes, and megakaryoblasts. In diseased cells, blasts in transient myeloproliferative disorder are positively stained. CD42b is used in diagnosis of acute…
Immunohistochemistry (IHC)
CD43 CD43 (leukosialin, sialophorin, or leukocyte sialoglycoprotein) is a cell surface glycoprotein that is expressed on all thymocytes, T-cells, and cells of myeloid lineage. CD43 antibody can be useful…
Immunohistochemistry (IHC)
CD44 The CD44 family of glycoproteins exists in a number of variant isoforms, including hematopoietic variant (CD44s) and epithelial cells variant (CD44v). While many human tumors express CD44, a positive…
Immunohistochemistry (IHC)
CD45 (LCA) CD45 (Leukocyte Common Antigen, LCA) is comprised of at least four isoforms (CD45RA, CD45RB, CD45RC and CD45RO) of membrane glycoproteins. CD45 is expressed on hematopoietic cells (human leukocytes,…
Immunohistochemistry (IHC)
CD45RO CD45RO (an isoform of leukocyte common antigen) reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. CD45RO antibody marks…
Immunohistochemistry (IHC)
CD5 CD5, a transmembrane protein, is found on most thymocytes and immature peripheral T-cells. It stains normal B-cells of mantle zone of spleen and lymph nodes, B-cells in peritoneal and pleural…
Immunohistochemistry (IHC)
CD56 CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally-derived cell lines, tissues and neoplasms (e.g. retinoblastoma,…
Immunohistochemistry (IHC)
CD57 CD57 is expressed on subpopulations of peripheral blood mononuclear cells, NK active cells and T-cells. Hematopoietic malignancies that are CD57+ include a minority of T-lymphoblastic leukemias,…
Immunohistochemistry (IHC)
CD61 CD61 (GPIIIa) is a glycoprotein found on megakaryocytes, platelets, and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von…
Immunohistochemistry (IHC)
CD68 CD68 is an antibody directed against lysosomes. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and…
Immunohistochemistry (IHC)
CD7 CD7 is expressed on the majority of immature and mature T-lymphocytes and T-cell leukemia. It is also found on natural killer cells, and a small subpopulation of normal and malignant B-cells. CD7…
Immunohistochemistry (IHC)
CD71 CD71 is useful in identifying erythroid precursors with no interference from mature erythrocytes and also in the determination of erythroid leukemia, benign erythroid proliferative disorders, and…
Immunohistochemistry (IHC)
CD79a CD79a first appears at the pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B-…
Immunohistochemistry (IHC)
CD8 CD8 is a T-cell marker for the detection of cytotoxic/suppressor T-cells. CD8 is also detected on NK cells, most thymocytes, a subpopulation of null cells, and bone marrow cells. This antibody is…
Immunohistochemistry (IHC)
CD99 CD99 (MIC2 gene product, E2) antigen is strongly expressed by Ewing sarcoma cells, primitive peripheral neuroectodermal tumors, and lymphoblastic leukemia/lymphoma.
Immunohistochemistry (IHC)
CDK4 Among cyclin/CDK proteins, CDK4 and cyclin D1 are the most frequently activated by somatic genetic alterations in multiple tumor types. CDK4 antibody assists in distinguishing atypical lipomatous…
Immunohistochemistry (IHC)
CDX2 CDX2 is an intestine specific transcription factor that regulates both the proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells…
Immunohistochemistry (IHC)
CDX2/CK7 Double Stain CDX2 is a transcription factor expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal…
Immunohistochemistry (IHC)
CEA (Mono) Carcinoembryonic antigen (CEA) is usually demonstrated as a linear labeling of the apical poles of cells lining the glandular lumen and occasionally as weak staining near the apex of normal colonic…
Immunohistochemistry (IHC)
CEA (Poly) Polyclonal carcinoembryonic antigen (CEA) antibody stains a larger percentage of cholangiocarcinomas compared to hepatocellular carcinomas. Approximately 95% of olangiocarcinomas are stained…
Immunohistochemistry (IHC)
Chromogranin A Chromogranin is present in several elements of the diffuse neuroendocrine system (DNES), including anterior pituitary, thyroid perifollicular C cells, parathyroid chief cells, pancreatic islet cells…
Immunohistochemistry (IHC)
CK 10/13 (Cytokeratin 10/13) Cytokeratins 10 and 13 are intermediate-size, acidic type I cytokeratins (molecular mass of 56.5 kDa). CK10/13 cocktail is expressed in all suprabasal cells of normal stratified squamous epithelium,…
Immunohistochemistry (IHC)
Pan-Cytokeratin Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies of cytokeratin, respectively, thus the combination of these two antibodies can be used to detect almost all human…
Immunohistochemistry (IHC)
CAM 5.2 Anti-Cytokeratin (CAM 5.2) has a primary reactivity with human keratin proteins that correspond to Moll`s peptides #7 and #8, Mr 48 and 52 Kd. Cytokeratin 8 is present on secretory epithelia of…
Immunohistochemistry (IHC)
CK HMW (CK903/34BE12) CK903 (34betaE12) is a high molecular weight cytokeratin present in all squamous epithelium and their carcinomas. This antibody recognizes cytokeratins 1, 5, 10 and 14 that are found in complex…
Immunohistochemistry (IHC)
CK HMW/CK LMW Double Stain This cytokeratin cocktail can be useful in differentiation of the squamous cell carcinomas and adenocarcinomas. The 34bE12 clone recognizes cytokeratin (CK) 1, 5, 10 and 14. It is reactive with…
Immunohistochemistry (IHC)
CK OSCAR Anti-cytokeratin clone OSCAR (CK OSCAR) demonstrates a broad spectrum of cytokeratin reactivity. In normal tissues, OSCAR is reactive with most epithelial types, including bile ducts and hepatocytes…
Immunohistochemistry (IHC)
CK14 (Cytokeratin 14) Cytokeratin 14 (CK14) belongs to the type A (acidic) subfamily of high molecular weight keratins and exists in combination with keratin 5. CK14 has been studied as a prognostic marker in breast…
Immunohistochemistry (IHC)
CK17 Cytokeratin 17 (CK17) is an effective marker to distinguish myoepithelial cells from luminal epithelium of various glands (mammary, sweat, salivary, bronchial, tracheal, laryngeal, esophageal) and…
Immunohistochemistry (IHC)
CK18 (Cytokeratin 18) Cytokeratin 18 (CK 18), a 45kDa protein, belongs to the acidic type of cytokeratins, and is typically expressed in simple, nonstratified epithelia. However, CK 18 is also expressed in basal and…
Immunohistochemistry (IHC)
CK19 Cytokeratin 19 (CK19) is a member of the type I acidic subfamily of keratins. It is expressed in various different human tissues. CK19 labels ductal and glandular epithelia, prostatic epithelia, and…
Immunohistochemistry (IHC)
CK20 Cytokeratin 20 (CK20) positivity is seen in the majority of adenocarcinomas of the colon, mucinous ovarian carcinomas, transitional cell, and Merkel cell carcinomas, and frequently in adenocarcinomas…
Immunohistochemistry (IHC)
CK5/6 D5/16 B4 clone of CK5/6 antibody reacts strongly with cytokeratins 5 and 6. Cytokeratin 5/6 have been found valuable for the distinction between low differentiated squamous cell carcinoma and…
Immunohistochemistry (IHC)
CK7 Cytokeratin 7 (CK7) antibody reacts with proteins that are found in most ductal, glandular and transitional epithelium of the urinary tract and bile duct epithelial cells. CK7 distinguishes between…
Immunohistochemistry (IHC)
cMET The cMET tyrosine kinase receptor, normally expressed by epithelial cells, is overexpressed and amplified in a variety of human tumors, including non-small cell lung carcinoma (NSCLC). High levels of…
Immunohistochemistry (IHC)
CMV (Cytomegalovirus) by IHC Cytomegalovirus (CMV) is an opportunistic pathogen infecting lung, kidney, gut and other organs in situations where an individual is immunologically immature, such as the fetus and neonate. Infection…
Immunohistochemistry (IHC)
cMyc cMyc protein is a transcription factor localized to the nucleus of the cell. Amplification of the cMyc gene has been found in several types of human tumors. cMyc is amplified in 20-30% of breast…
Immunohistochemistry (IHC)
Collagen IV Collagen IV is a major constituent of the basement membranes along with laminins and enactins. In kidney, the antibody reacts with glomerular and tubular basement membranes, parts of the mesenchymal…
Immunohistochemistry (IHC)
Congo Red Special stain.
Immunohistochemistry (IHC)
Copper Stain Special stain.
Immunohistochemistry (IHC)
COX2 Cyclooxygenase-2 (COX-2) plays a role in tumorigenesis through stimulating epithelial cell proliferation, inhibiting apoptosis, stimulating angiogenesis, enhancing cell invasiveness, mediating immune…
Immunohistochemistry (IHC)
cREL Inactive cREL resides in the cytoplasm and translocates to the nucleus upon activation. Strong, homogeneous nuclear cREL staining has been observed in primary mediastinal large B-cell lymphoma…
Immunohistochemistry (IHC)
Inhibin Anti-Inhibin alpha is an antibody against a peptide hormone which has a demonstrated utility in differentiating between adrenocortical tumors and renal cell carcinoma. This antibody stains most…
Immunohistochemistry (IHC)
DBA.44 This antibody reacts with a subset of B-cells in the mantle zone and some immunoblasts outside the follicle. It reacts with most hairy cell leukemia cases. This antibody shows strong positive…
Immunohistochemistry (IHC)
Desmin Desmin is an intermediate filament protein of both smooth and striated muscles. Antibody to desmin reacts with striated (skeletal and cardiac) as well as smooth muscle cells. Anti-desmin antibody is…
Immunohistochemistry (IHC)
DOG1 DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). Among GIST cases with Kit mutations the DOG1 antibody identified 11% more cases…
Immunohistochemistry (IHC)
DPC4 The gene DPC4 (deleted in pancreatic carcinoma 4, also called SMAD4) was identified in 18q21.3 This gene is frequently mutated and deleted in pancreatic carcinomas (55%) and less frequently (20 - 22…
Immunohistochemistry (IHC)
E-Cadherin E Cadherin is an adhesion protein that is expressed in cells of epithelial lineage. It stains positively in glandular epithelium, as well as adenocarcinomas of the lung, G.I. tract and ovary. It is…
Immunohistochemistry (IHC)
EBV (LMP1) This antibody reacts strongly with Epstein Barr Virus (EBV)-positive lymphoblastoid cell lines and EBV infected B-cell immunoblasts in infectious mononucleosis. It also reacts with some EBV-…
Immunohistochemistry (IHC)
EGFR Epidermal Growth Factor Receptor (EGFR) overexpression can occur in a variety of tumor types, including breast, prostate, ovarian, brain, lung and predominantly squamous cell carcinomas. Tumors that…
Immunohistochemistry (IHC)
EGFR (E746-A750del specific) Epidermal Growth Factor Receptor (EGFR) is a 170 kDa transmembrane receptor tyrosine kinase that belongs to the HER/ErbB protein family. Somatic mutations in the tyrosine kinase domain of EGFR are…
Immunohistochemistry (IHC)
EGFR (L858R mutant specific) Epidermal Growth Factor Receptor (EGFR) is a 170 kDa transmembrane receptor tyrosine kinase that belongs to the HER/ErbB protein family. Somatic mutations in the tyrosine kinase domain of EGFR are…
Immunohistochemistry (IHC)
Elastic Stain Special stain.
Immunohistochemistry (IHC)
EMA Epithelial Membrane Antigen (EMA) antibody stains normal and neoplastic cells from various tissues, including mammary epithelium, sweat glands and squamous epithelium. Hepatocellular carcinoma,…
Immunohistochemistry (IHC)
ER Estrogen Receptor (ER) belongs to a superfamily of nuclear hormone receptors and is expressed in about 85% of invasive breast cancers. There are two known isoforms of estrogen receptor, ERα and ERß.…
Immunohistochemistry (IHC)
ERCC1 The Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 1 (ERCC1) polypeptide is required for nucleotide excision repair (NER) of damaged DNA. Elevated levels of ERCC1…
Immunohistochemistry (IHC)
ERG ERG oncoprotein expression has been shown to be a highly specific marker for prostate cancer. Given the lack of ERG expression in a wide variety of normal epithelial tissues and tumors, detection of…
Immunohistochemistry (IHC)
Factor VIII RA Factor VIII-related antigen is a component of Factor VIII complex. Factor VIII-related antigen is one of the available immunohistochemical markers of endothelial cells. It has also been demonstrated…
Immunohistochemistry (IHC)
Factor XIIIa Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and…
Immunohistochemistry (IHC)
Fascin Human fascin is a highly conserved actin-bundling protein. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative for staining. However, Reed-…
Immunohistochemistry (IHC)
Fite (Leprosy) Stain Special stain.
Immunohistochemistry (IHC)
FLi-1 Friend leukemia integration (FLI1) is a nuclear transcription factor and has been reported as the first nuclear marker of endothelial differentiation. FLI1 labels hemangiomas, angiosarcomas, Kaposis…
Immunohistochemistry (IHC)
Fontana Masson Special stain.
Immunohistochemistry (IHC)
FOXP1 FOX P1 (Forkheadbox-P1) is a transcription factor widely expressed in normal tissues. Its expression is commonly deregulated in malignancies. FOX P1 is differentially expressed in resting and…
Immunohistochemistry (IHC)
FOXP3 FOX P3 is expressed at a high level in CD25 positive/CD4 positive regulatory T cells, at a low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOX P3…
Immunohistochemistry (IHC)
FSH Follicle Stimulating Hormone (FSH) is a pituitary hormone involved in the maturation of ovarian follicles and estrogen secretion in females. In the pituitary gland, FSH is produced by gonadotrophs.…
Immunohistochemistry (IHC)
Galectin 3 Galectins are a structurally-related family of proteins; 14 different galectins have been characterized. They are cytoplasmic proteins and can be translocated into the nucleus. Gal-3 has been found…
Immunohistochemistry (IHC)
Gastrin Gastrin, a polypeptide hormone, occurs naturally in three forms: gastrin-14, gastrin-17 and gastrin-34. This antibody labels gastrin or gastrin-analogue producing cells in gastrin-secreting tumors…
Immunohistochemistry (IHC)
GATA3 GATA3 (GATA binding protein 3) is a member of the GATA family of transcription factors. Among several other roles, GATA3 is involved in luminal cell differentiation in the mammary gland and appears…
Immunohistochemistry (IHC)
GCDFP15 This antibody is specific to a 15kDa monomer protein called Gross Cystic Disease Fluid Protein-15 (GCDFP-15). GCDFP15 is expressed in apocrine epithelia, lacrimal, ceruminous and Moll’s glands, as…
Immunohistochemistry (IHC)
GCET1 The GCET1 gene codes for a serpin expressed in germinal center (GC) B-cells. GCET1 is highly restricted to a subset of GC B-cells and GC-derived lymphomas. It is preferentially expressed in…
Immunohistochemistry (IHC)
GFAP Glial Fibrillary Acidic Protein (GFAP) is the major protein found in astrocytes and its expression is evidence of astroglial origin and differentiation. Gliomas are the most common cerebral neoplasm…
Immunohistochemistry (IHC)
GH Growth Hormone (GH) is produced by the somatotroph cells in the pituitary. This marker is a useful in classification of pituitary tumors and the study of pituitary disease (acromegaly).
Immunohistochemistry (IHC)
Giemsa for sections Special stain.
Immunohistochemistry (IHC)
HPL Human Placental Lactogen (HPL) is a polypeptide hormone synthesized in syncytiotrophoblastic cells of placenta and has been used as a tissue marker for certain trophoblastic tumors.
Immunohistochemistry (IHC)
GLUT1 Glucose transporter 1 (GLUT1) facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT-1 is expressed in many human tissues including those of the colon, lung,…
Immunohistochemistry (IHC)
Glycophorin A Glycophorin A (sialoglycoprotein alpha) is one of two transmembrane proteins exposed on the outer surface of normal human erythrocytes. This monoclonal antibody reacts with an epitope located on the…
Immunohistochemistry (IHC)
Glypican-3 A useful marker to differentiate between benign (negative) and malignant (positive) liver diseases (HCCs).
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Granzyme B Granzyme B antibody labels activated human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. This marker can be a useful tool for the identification of anaplastic large cell lymphoma,…
Immunohistochemistry (IHC)
Grocott Methanamine Silver (GMS) Special stain. GMS (Grocott Methenamine-Silver Nitrate) Fungus Stain is used to demonstrate fungal organisms in tissue sections.
Immunohistochemistry (IHC)
GST Pi Glutathione S Transferase Pi (GSTpi) is a cytosolic enzyme that catalyzes the conjugation of toxic compounds to glutathione for transport out of the cell. Increased expression of GSTp has been…
Immunohistochemistry (IHC)
IDH1 IDH1 mutations are frequent genetic alterations in low-grade diffuse gliomas and secondary glioblastoma (70%). This alteration is observed in fewer than 10% of primary GBM cases. IDH1 IHC antibody is…
Immunohistochemistry (IHC)
Colloidal Iron Special stain.
Immunohistochemistry (IHC)
Hall Bile Stain Special stain.
Immunohistochemistry (IHC)
HBME1 HBME1 is an anti-mesothelial monoclonal antibody that recognizes an unknown antigen on the microvilli of mesothelioma cells. It stains normal mesothelial cells as well as epithelial mesotheliomas in…
Immunohistochemistry (IHC)
HCG-Beta (Human Chorionic Gonadotropin Beta) HCG-beta is secreted in large quantities by the placenta and normally is found in maternal circulation during early fetal development. Polyclonal Rabbit Anti-Human Chorionic Gonadotropin is intended…
Immunohistochemistry (IHC)
Hemoglobin A Hemoglobin A antibody reacts with the alpha chain of adult hemoglobin A. This antibody is useful in the detection of red blood cell precursors. Immunohistochemical localization of hemoglobin is…
Immunohistochemistry (IHC)
H. Pylori This antibody reacts with H. pylori on the surface and in the cytoplasm of epithelial cells of stomach biopsies. Studies have shown that H. pylori plays an important role in the etiology of chronic…
Immunohistochemistry (IHC)
D240 D2 40 identifies a 40kDa O-linked sialoglycoprotein expressed by a variety of tissues, including fetal testes and testicular germ cell tumors. Anti-D2 40 has also been demonstrated to label lymphatic…
Immunohistochemistry (IHC)
Hepatitis B Core Antigen Hepatitis B virus belongs to the hepatovirus family and causes type B hepatitis. Hepatitis B virus is spherical in shape with a diameter of 42 nm. Core antigens are localized within the nuclei,…
Immunohistochemistry (IHC)
HGAL HGAL is specifically expressed in the cytoplasm of germinal center B-cells, but is absent in mantle and marginal zone. This antibody is highly specific for germinal center B-cells and it is an ideal…
Immunohistochemistry (IHC)
HHV8 Human Herpes Virus (HHV) 8 is the likely etiological agent of Kaposi’s sarcoma (KS), and is present in all cases. HHV 8 encodes a latent nuclear antigen (LANA) that is the product of the viral gene…
Immunohistochemistry (IHC)
HMB45 Antibody clone HMB45 recognizes a melanoma-specific antigen by reacting with melanoma cells, nevus cells and neonatal melanocytes. HMB45 is expressed on the majority of malignant melanoma cases as…
Immunohistochemistry (IHC)
Hepatitis B Surface Antigen Hepatitis B virus, belongs to the hepatovirus family, and causes type B hepatitis. It is spherical in shape with a diameter of 42 nm. It contains a 27 nm partially double stranded DNA core enclosed…
Immunohistochemistry (IHC)
HSV I/II This antibody cocktail reacts with Herpes Simplex Virus (HSV) type 1- or type 2-specific antigens and with antigens common to both types. The antibodies react with all the major glycoproteins present…
Immunohistochemistry (IHC)
Serotonin Serotonin is synthesized in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract and serotonin-containing carcinoid tumors. Serotonin may be a…
Immunohistochemistry (IHC)
SF1 SF1 is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli cells, and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF1 is highly valuable…
Immunohistochemistry (IHC)
Simian Virus 40 (SV40) Simian Virus 40 (SV40) is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors. SV40 is believed to suppress…
Immunohistochemistry (IHC)
SMMHC Smooth Muscle Myosin, Heavy Chain (SMMS-1) is an antibody to smooth muscle myosin, heavy chain that reacts with human visceral and vascular smooth muscle cells. The antibody also reacts with human…
Immunohistochemistry (IHC)
Smoothelin Smoothelin is a novel cytoskeletal protein that reacts with the 59 kDa and 100 kDa proteins corresponding to Smoothelin A and B, respectively, which are exclusively found in smooth muscle cells (SMC…
Immunohistochemistry (IHC)
NeoLAB™ AML Profile - Liquid Biopsy This test is performed by sequencing the entire coding regions of the genes listed using cell-free plasma DNA/RNA. ASXL1, BCOR, BRAF, CEBPA, CSF3R, DNMT3A, ETV6, EZH2, FLT3, HRAS, IDH1, IDH2, JAK2…
Molecular
Somatostatin (Receptor Type 2) Somatostatin receptor type 2 (sstr2) is a receptor for somatostatins-14 and -28. This antibody has a great value in the assessment of sst2A status in human neuroendocrine tumors. Overexpression of…
Immunohistochemistry (IHC)
SOX10 SOX10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is also a useful marker in detecting both the in situ and invasive components of desmoplastic…
Immunohistochemistry (IHC)
SOX11 Nuclear protein expression of SOX-11 is highly associated with both cyclin D1-positive and negative mantle cell lymphoma (MCL). SOX-11 IHC is useful for identifying true cyclin D1-negative MCL and…
Immunohistochemistry (IHC)
NeoLAB™ IDH1 Mutation Analysis - Liquid Biopsy Bi-directional sequencing of the exon 4 mutation hotspot region in the IDH1 gene. Testing is performed on cell-free plasma DNA/RNA to increase sensitivity.
Molecular
Spirochete Spirochete (Treponema pallidum) is the causative agent of syphilis. In the past, localization of the spirochete agent was achieved with silver stains such as Steiners and/or Warthin-Starry. Treponema…
Immunohistochemistry (IHC)
NeoLAB™ IDH2 Mutation Analysis - Liquid Biopsy Bi-directional sequencing of the exon 4 mutation hotspot region in the IDH2 gene. Testing is performed on cell-free plasma DNA/RNA to increase sensitivity.
Molecular
Synaptophysin Antibody to synaptophysin reacts with neuroendocrine neoplasms of neural as well as epithelial types. In combination with chromogranin A and NSE antibodies, the antibody to synaptophysin is very…
Immunohistochemistry (IHC)
TRAcP TRAP IHC is of use in the identification of hairy cell leukemia, but it is not a completely specific marker.
Immunohistochemistry (IHC)
TCL1 T-cell leukemia/lymphoma protein 1 (TCL1) is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of…
Immunohistochemistry (IHC)
TCRβF1 T Cell Receptor beta (TCRβ) is used as a phenotypic marker for TCRβ expressing T-cells. TCRβ is expressed by thymocytes and a majority of peripheral (α/β TCR-bearing) T-cells. This antibody does not…
Immunohistochemistry (IHC)
TdT (Terminal Deoxynucleotidyl Transferase) TdT is a highly specific marker for the diagnosis and classification of acute lymphoblastic lymphoma/leukemias. The determination of TdT expression is most valuable when it is important to…
Immunohistochemistry (IHC)
TFE3 Overexpression of TFE3 is a sensitive and specific marker of Xp11 translocation in renal cell carcinomas. TFE3 is also expressed in alveolar soft part sarcoma the hallmark of which is a chromosomal…
Immunohistochemistry (IHC)
Thrombomodulin (TM) Thrombomodulin (TM) is a plasma membrane-related glycoprotein that has anticoagulant activity. TM antigen is found in several cell types, including megakaryocytes, mesangial cells, synovial cells,…
Immunohistochemistry (IHC)
NeoLAB™ inv(16), CBFB-MYH11 Translocation - Liquid Biopsy Real-time RT-PCR for quantitative detection of the inv(16) CBFB-MYH11 fusion transcript using cell-free plasma DNA/RNA. This assay identifies type A fusions, which account for >90%
Molecular
TIA1 TIA1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. Most anaplastic large…
Immunohistochemistry (IHC)
TLE1 Expression of the transducing-like receptor (TLE) genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state. TLE1…
Immunohistochemistry (IHC)
Toxoplasma Toxoplasma is a crescent shaped sporozoan that lives as an intracellular parasite in various tissues of vertebrates and completes its life cycle in a single host. This antibody helps to identify the…
Immunohistochemistry (IHC)
Trichrome Special stain. Trichrome stains are frequently used to differentiate between collagen and smooth muscle in tumors and to identify increases in collagenous tissue in diseases such as cirrhosis of the…
Immunohistochemistry (IHC)
Tryptase This antibody labels a mast cell tryptase. It will also show reactivity to basophils, but to a lesser degree.
Immunohistochemistry (IHC)
TS (Thymidylate Synthase) Antibody MAB4130 recognizes a 36 kDa protein identified as Thymidylate Synthase [TS], which is a target for the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors. Expression…
Immunohistochemistry (IHC)
NeoLAB™ KIT (c-KIT) Mutation Analysis - Liquid Biopsy Bi-directional sequencing of KIT exons 8, 9, 11, 13 and 17 for detection of activating mutations including the common mutation D816V. Testing is performed on cell-free plasma DNA/RNA to increase…
Molecular
TTF1 Thyroid Transcription Factory (TTF1) is found is found predominantly in lung and thyroid neoplasms.  The utility of TTF1 becomes apparent in the differential diagnosis of primary versus metastatic…
Immunohistochemistry (IHC)
Tuberculosis Mycobacterium tuberculosis is the most common cause of tuberculosis. Immunohistochemical demonstration of mycobacterial antigens is not only useful in establishing mycobacterial etiology, but can…
Immunohistochemistry (IHC)
Tyrosinase Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. Mutations of the tyrosinase gene occur in various forms of albinism.…
Immunohistochemistry (IHC)
NeoLAB™ RUNX1-RUNX1T1 (AML1-ETO) Translocation, t(8;21) - Liquid Biopsy Real-time RT-PCR for quantitative detection of the t(8;21) RUNX1-RUNX1T1 fusion transcript (formerly called AML1-ETO) using cell-free plasma DNA/RNA.
Molecular
Uroplakin III Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non-neoplastic urothelium, UPIII is expressed in…
Immunohistochemistry (IHC)
Varicella Zoster Virus (VZV) Varicella Zoster Virus (VZV), a member of the human herpes virus family, causes two distinct clinical manifestations: chickenpox and shingles. Primary VZV infection results in chickenpox (varicella…
Immunohistochemistry (IHC)
Vascular Endothelial Growth Factor (VEGF) Vascular endothelial growth factor (VEGF) is a glycoprotein involved in angiogenesis that promotes tumor progression and metastasis. VEGF is a mitogen for vascular endothelial cells derived from…
Immunohistochemistry (IHC)
RUNX1-RUNX1T1 (AML1-ETO) Translocation, t(8;21) Real-time RT-PCR for quantitative detection of the t(8;21) RUNX1-RUNX1T1 fusion transcript (formerly called AML1-ETO). Analytical sensitivity is 1 tumor cell in 100,000 normal cells. Positive results…
Molecular
Vimentin Vimentin is the major intermediate filament in a variety of mesenchymal cells, including endothelial cells, all fibroblastic cells, macrophages, Sertoli cells, melanocytes, lymphocytes and ovarian…
Immunohistochemistry (IHC)
Warthin Starry Special stain. Warthin Starry stain is intended to identify Helicobacter pylori in tissue samples.
Immunohistochemistry (IHC)
Wright Giemsa Cytochemical stain. The Wright Giemsa stain is used to stain peripheral blood and bone marrow smears for study of blood cell morphology.
Immunohistochemistry (IHC)
WT1 Wilms tumor susceptibility gene 1 protein (WT1) has diagnostic utility in the distinction of mesothelioma from adenocarcinoma in tissue sections of pleural tumors. WT1 diffusely stains most ovarian…
Immunohistochemistry (IHC)
WT1 Mutation Analysis Bi-directional sequencing of exons 7 and 9 is performed for detection of sequence variant mutations.  Fragment analysis of exon 7 is also performed for enhanced detection of heterozygous insertion/…
Molecular
CMV In situ hybridization for detection of cytomegalovirus (CMV) RNA.
In Situ Hybridization (ISH)
EBER This probe set labels all latent EBV-infected cells, including EBV-positive lymphoblastoid cell lines and EBV infected B-cell immunoblasts in infectious mononucleosis. It also reacts with EBV-…
In Situ Hybridization (ISH)
NPM1 MRD Analysis NPM1 MRD Analysis is performed by PCR and fragment analysis of exon 12 of the NPM1 gene to detect small insertion mutations. Testing is performed on plasma with a PCR modification to improve…
Molecular
Kappa Each test contains a set of oligonucleotide probes. The intended target is the kappa light chain immunoglobulin messenger RNA (mRNA) in the cytoplasm of immunoblastic cells, plasma cells and…
In Situ Hybridization (ISH)
Lambda Each test contains a set of oligonucleotide probes. The intended target is the lambda light chain immunoglobulin messenger RNA (mRNA) in the cytoplasm of immunoblastic cells, plasma cells and…
In Situ Hybridization (ISH)
Uroplakin II Uroplakin II is a 15 kDa protein component of urothelial plaques. Uroplakin II mRNA was found in both bladder cancer tissues and peripheral blood of patients with primary and metastatic urothelial…
Immunohistochemistry (IHC)
PD-L1 SP263 FDA (IMFINZI™) The VENTANA PD-L1 (SP263) assay is an FDA-approved complementary diagnostic IHC test for PD-L1 status in patients with locally advanced or metastatic urothelial carcinoma (mUC) who are being…
Immunohistochemistry (IHC)
Mammaglobin Mammaglobin is a breast-associated glycoprotein. In normal breast tissue, this antibody labels breast ductal and lobular epithelial cells. In tumor cells, they are reactive with all types of breast…
Immunohistochemistry (IHC)
p120 Catenin P120 Catenin is a tyrosine kinase which binds to E-cadherin within the cell membrane. It is detectable in the cell membranes of a wide variety of cells, but predominates in virtually all types of…
Immunohistochemistry (IHC)
NeoTYPE® Breast Tumor Profile The NeoTYPE Breast Tumor Profile analyzes 28 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all…
Molecular
NeoTYPE® Discovery Profile for Solid Tumors This profile analyzes 334 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary interpretation of…
Molecular
TOP2A Probes: TOP2A (17q21-q22) | Cen 17 (17p11.1-q11.1)Disease(s): Breast cancerNote: Available as a global test only.
FISH
LH Luteinizing Hormone (LH) is a tropic hormone that modulates the secretory activity of other endocrine glands. It is produced in the anterior hypophysis of the pituitary gland. LH antibody is useful…
Immunohistochemistry (IHC)
NeuN NeuN is a sensitive and specific marker of neuronal differentiation in brain tumors.
Immunohistochemistry (IHC)
Olig2 Olig2, a transcription factor, is involved in oligodendroglial specification. Olig2 expression has been reported in most glial tumors, such as oligodendrogliomas and astrocytomas. Olig2 is negative…
Immunohistochemistry (IHC)
NeoTYPE® JMML Profile This test is performed by sequencing the entire coding regions of the genes listed. BRAF, CBL, CEBPA, FLT3, HRAS, JAK2 including V617F and Exons 12+14, JAK3, KIT, KRAS, NPM1, NRAS, PDGFRA, PTEN,…
Molecular
NeoTYPE® Liver/Biliary Tumor Profile The NeoTYPE Liver/Biliary Tumor Profile analyzes 29 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below.  Test orders include summary interpretation of…
Molecular
Prolactin Prolactin is a growth factor secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Prolactin antibody is useful in the identification…
Immunohistochemistry (IHC)
NeoTYPE® Lymphoma Profile This test is performed by multiple methods to detect mutations in the following genes BCL1, BCL2, BCL6, BRAF, CARD11, CD79B, EZH2, MYD88, NOTCH1, NOTCH2, NRAS and TP53. The test is performed by…
Molecular
NeoTYPE® MDS/CMML Profile This test is performed by sequencing the entire coding regions of the genes listed unless another method is noted. ASXL1, BCOR, BCORL1, BRAF, CBL, CEBPA, CUX1, DNMT3A, ETV6, EZH2, FLT3, HRAS, IDH1,…
Molecular
NeoTYPE® Melanoma Profile The NeoTYPE Melanoma Tumor Profile analyzes 22 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include…
Molecular
SOX2 SOX2 stains all embryonal carcinomas and is highly specific for squamous cell carcinoma.
Immunohistochemistry (IHC)
NeoTYPE® Myeloid Disorders Profile This test is performed by the sequencing the entire coding regions of the genes listed. ABL1, ASXL1, ATRX, BCOR, BCORL1, BRAF, CALR, CBL, CBLB, CBLC, CDKN2A, CEBPA, CSF3R, CUX1, DNMT3A, ETV6, EZH2,…
Molecular
NeoTYPE® Other Solid Tumor Profile This profile analyzes 29 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide…
Molecular
TSH Thyroid Stimulating Hormone (TSH) is a pituitary hormone of 28 kDa that stimulates thyroid growth and production of thyroid hormones. This antibody labels thyrotropic cells of the pituitary and may…
Immunohistochemistry (IHC)
NeoTYPE® Brain Tumor Profile The NeoTYPE Brain Tumor Profile analyzes 48 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include summary…
Molecular
NeoTYPE® Precision Profile for Solid Tumors This Profile analyzes 51 biomarkers through a combination of next-generation sequencing (NGS) and IHC as listed below. Test orders include summary interpretation of all results to help guide…
Molecular
ATRX Mutation Analysis Bi-directional Sanger sequencing of ATRX is performed using PCR primers designed to target hotspot mutations in exons 8-10, 12-15, 17, 18, 21, 22, 26, 30-32, and 35.
Molecular
ABL1 Kinase Domain Mutation Analysis RT-PCR and sequencing of the BCR-ABL1 fusion transcript for qualitative detection of mutations associated with resistance to Gleevec (imatinib) and other tyrosine kinase inhibitors. Analysis includes…
Molecular
EGFRvIII Analysis The EGFRvIII Analysis test is a real-time quantitative RT-PCR assay that is capable of detecting the EGFRvIII mutation that results from an inframe deletion of 801 base pairs spanning exons 2-7 of…
Molecular
ATRX ATRX mutations predominantly occur in grade II/III astrocytoma and secondary glioblastoma multiforme (GBM) brain tumors. ATRX loss defines a subgroup of astrocytic tumors with a favorable prognosis.
Immunohistochemistry (IHC)
ASXL1 Mutation Analysis Bi-directional sequencing of the majority of exons 13 and 14 of ASXL1, corresponding to amino acids 406-1396.
Molecular
p16 p16 (p16 -INK4a, p16-MTS1, inhibitor of CDK4) is the product of the CDKN2 gene. It inhibits the progression of the cell cycle through the G1 phase. p16 is a candidate tumor suppressor, whose gene is…
Immunohistochemistry (IHC)
B-Cell Gene Rearrangement Detection of clonal IgH gene rearragements by PCR of IgH framework regions 1, 2, 3 and joining regions. In addition, Ig Kappa gene rearrangement analysis is performed using specific oligonucleotides…
Molecular
BCL1 Translocation, t(11;14) Real-time PCR for quantitative detection of t(11;14) BCL1/IgH rearrangements. Analytical sensitivity is approximately 1 tumor cell in 1000 normal cells. Positive results are reported as a ratio…
Molecular
BCL2 Translocation, t(14;18) PCR and fragment analysis for quantitative detection of IGH-BCL2 translocations associated with 70-80% of follicular lymphoma and approximately 20% of diffuse large B-cell lymphoma. Translocations…
Molecular
BCR-ABL1 Standard p210, p190 Real-time RT-PCR for quantitative detection of t(9;22) BCR-ABL1 fusion transcripts that result in major p210 (E13, E14) or minor p190 (E1) fusion proteins with option to add p230 detection (micro or…
Molecular
BRAF Mutation Analysis Bi-directional sequencing of exon 15 of the BRAF gene, which includes qualitative detection of V600 mutations E, K, D, and others, plus other significant exon 15 mutations.  For solid tumors, tumor…
Molecular
BRCA1 Mutation & Del/Dup Analysis This test is performed by sequencing the entire BRCA1 gene using next-gen sequencing complemented by conventional Sanger sequencing or other molecular methodologies to detect point mutations, small…
Molecular
BRCA1/2 Mutation & Del/Dup Analysis This test is performed by sequencing the entire BRCA1 and BRCA2 genes using massive parallel sequencing complemented by conventional Sanger sequencing or other molecular methodologies to detect point…
Molecular
BRCA2 Mutation & Del/Dup Analysis This test is performed by sequencing the entire BRCA2 gene using next-gen sequencing complemented by conventional Sanger sequencing or other molecular methodologies to detect point mutations, small…
Molecular
BTK Inhibitor Acquired Resistance Panel Concurrent bi-directional sequencing of hotpost regions in the BTK and PLC-gamma-2 genes. Analysis includes the BTK mutation C481S and surrounding regions corresponding to amino acids C464 to M509…
Molecular
BTK Inhibitor Primary Susceptibility Panel Concurrent analysis of the following by bi-directional sequencing: CARD11 exons 5 and 6, CD79B exon 5 including common Y196 mutations, CXCR4 C-terminus region, and MYD88 exon 5 including the L265P…
Molecular
BTK Mutation Analysis Bi-directional sequencing to detect the C481S mutation in exon 15 and other potential mutations within the amino acid range C464 to M509. Testing is available separately or in combination with PLC-…
Molecular
NeoTYPE® Cervical Tumor Profile The NeoTYPE Cervical Tumor Profile analyzes 27 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all…
Molecular
CARD11 Mutation Analysis Bi-directional sequencing of exons 5 and 6 of the CARD11 gene. Testing is available separately or as part of the NeoTYPE™ Lymphoma Profile.
Molecular
CBL Mutation Analysis Bi-directional sequencing of exons 8 and 9 of the CBL gene.
Molecular
CD79B Mutation Analysis Bi-directional sequencing of exon 5 of the CD79B gene which includes detection of the common Y196 mutations. Testing is available separately or as part of the NeoTYPE™ Lymphoma Profile.
Molecular
CEBPA Mutation Analysis Bi-directional sequencing of the relevant coding region and fragment analysis for detection of sequence variant and internal tandem duplication mutations. The SNP genotype at rs34529039 is reported.…
Molecular
DNA Fingerprinting Analysis STR (short tandem repeat) analysis by PCR and capillary electrophoresis (fragment analysis) is used to define sample identity and to identify mixtures of two or more genotypes within a single sample…
Molecular
Comprehensive Hereditary Cancer Panel Testing is performed by Blueprint Genetics.  Note: Patient signature on the Blueprint Genetics Informed Consent Form is required. Testing will be put on hold until a signed form is received. 
Molecular
MSH2 Human mismatch repair protein 2 (MSH2) is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Loss of MSH2 function leads to the…
Immunohistochemistry (IHC)
CXCR4 Mutation Analysis Bi-directional sequencing to detect nonsense, frameshift, and other mutations encoding the C-terminus of CXCR4. Analyzed range includes detection of the C1013G mutation and spans amino acids L301 to…
Molecular
DNMT3A Mutation Analysis Bi-directional sequencing of exon 26, a mutation hotspot region containing R882 and other mutations. In hematological disease, testing may be performed on plamsa to increase sensitivity. For solid…
Molecular
EGFR Mutation Analysis Bi-directional sequencing of exons 18-21 of the EGFR gene for detection of EGFR-activating mutations and TKI resistance mutations (including T790M) in these exons. Tumor enrichment is performed…
Molecular
MSH6 Mismatch repair (MMR) genes results in failure to repair errors in repetitive sequences that occur during DNA replication. The defects in DNA repair pathways have been related to tumor carcinogenesis…
Immunohistochemistry (IHC)
Villin This antibody recognizes villin, a cytoskeletal filament protein of 58 kDa found in human renal epithelial cells. Villin antibody is useful for the study of gastrointestinal cells in normal and tumor…
Immunohistochemistry (IHC)
EPCAM Mutation & Del/Dup Analysis This test is performed by sequencing the entire EPCAM gene using next-gen sequencing complemented by conventional Sanger sequencing or other molecular methodologies to detect point mutations, small…
Molecular
ETV6 Mutation Analysis Bi-directional sequencing of exons 2-7 of the ETV6 gene (formerly called TEL). This assay detects sequence variants rather than ETV6 translocations.
Molecular
ETV6-RUNX1 (TEL-AML1) Translocation, t(12;21) Real-time RT-PCR for quantitative detection of the t(12;21) ETV6-RUNX1 fusion transcript (formerly called TEL-AML1). Analytical sensitivity is 1 tumor cell in 100,000 normal cells. Positive results…
Molecular
EZH2 Mutation Analysis Bi-directional sequencing of exons 3-13 and 15-18 of the EZH2 gene.
Molecular
FLT3 Mutation Analysis Detection of internal tandem duplication and exon 20 tyrosine kinase domain (TKD) mutations using fragment-length analysis and bi-directional sequencing. Positive results identify specific TKD…
Molecular
GNAS Mutation Analysis Bi-directional sequencing of exons 8 and 9 of the GNAS gene to detect mutation hot spots in codons R201 and Q227.
Molecular
NeoTYPE® Colorectal Tumor Profile The NeoTYPE  Colorectal Tumor Profile analyzes 30 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include…
Molecular
HRAS Mutation Analysis Bi-directional sequencing of HRAS exons 2 and 3 which includes sites of common activating mutations in codons 12, 13, 59 and 61.
Molecular
IDH1 & IDH2 Mutation Analysis Bi-directional sequencing of the exon 4 mutation hotspot regions in both the IDH1 and IDH2 genes. IDH1 and IDH2 are analyzed concurrently. In hematological disease, testing may be performed on plasma…
Molecular
RAS/RAF Panel The RAS/RAF Panel is an NGS-based assay performed by sequencing the entire coding region (full gene) of BRAF, HRAS, KRAS and NRAS genes. The panel reports mutations detected in the full gene…
Molecular
Bone Marrow Failure Syndrome Panel Testing is performed by Blueprint Genetics.  Note: Patient signature on the Blueprint Genetics Informed Consent Form is required. Testing will be put on hold until a signed form is received.
Molecular
NeoTYPE® Endometrial Tumor Profile The NeoTYPE Endometrial Tumor Profile analyzes 28 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include…
Molecular
X/Y FISH for Molar Pregnancy Probes: Centromere X | Centromere YNote: Testing is performed only on a global basis at this time.Disease(s): Molar pregnancy (hydatidiform mole), partial mole, triploidy
FISH
MLH1 MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2, MSH6 and PMS2. During DNA replication, strand misalignment can occur resulting in…
Immunohistochemistry (IHC)
KIT (c-KIT) Mutation Analysis Bi-directional sequencing of KIT exons 8, 9, 11, 13 and 17 for detection of activating mutations including the common mutation D816V. For solid tumors, tumor enrichment is performed before extraction…
Molecular
MUC6 MUC6 is expressed mucopeptic neck cells and pyloric glands of the gastric mucosa. MUC6 antibody is recommended for use as part of a panel of antibodies in differentiation of gastric cancer.
Immunohistochemistry (IHC)
KRAS Exon 4 Mutation Analysis Bi-directional sequencing of exon 4 of the KRAS gene corresponding to amino acids  R97 through Q150.  Codon 117 and 146 mutations are detected. For solid tumors, tumor enrichment is performed before…
Molecular
KRAS Mutation Analysis Bi-directional sequencing of exons 2 and 3 of the KRAS gene. High-sensitivity sequencing is used for enhanced detection of mutations in codons 12, 13, 59, and 61.  For solid tumors, tumor enrichment…
Molecular
Lynch Syndrome This test is performed by sequencing the entire EPCAM, MLH1, MSH2, MSH6 and PMS2 genes using next-gen sequencing complemented by conventional Sanger sequencing or other molecular methodologies to…
Molecular
MET (c-MET) Mutation Analysis Bi-directional Sanger sequencing of MET is performed using PCR primers designed to target hotspot mutations in exons 14, 16, 17 and 19.
Molecular
MGMT Promoter Methylation Analysis Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the MGMT gene promoter. Percentage of methylated DNA (compared to total DNA) is reported for positive…
Molecular
NeoTYPE® Esophageal Tumor Profile The NeoTYPE Esophageal Tumor Profile analyzes 28 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include…
Molecular
MLH1 Mutation & Del/Dup Analysis This test is performed by sequencing the entire MLH1 gene using next-gen sequencing complemented by conventional Sanger sequencing or other molecular methodologies to detect point mutations, small…
Molecular
MLH1 Promoter Methylation Analysis This assay is performed on tumor tissue to detect hypermethylation of the MLH1 gene promoter. Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the…
Molecular
NeoTYPE® Gastric Tumor Profile The NeoTYPE Gastric Tumor Profile analyzes 28 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary…
Molecular
Microsatellite Instability Analysis (MSI) PCR and fragment analysis of paired normal and tumor tissue to determine microsatellite instability (MSI) at the standard five NCI-recommended loci. Positive results are reported as MSI-high (at…
Molecular
PD-L1 22C3 FDA (KEYTRUDA®) for Gastric/GEA PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded…
Immunohistochemistry (IHC)
MSH2 Mutation & Del/Dup Analysis This test is performed by sequencing the entire MSH2 gene using next-gen sequencing complemented by conventional Sanger sequencing or other molecular methodologies to detect point mutations, small…
Molecular
MSH6 Mutation & Del/Dup Analysis This test is performed by sequencing the entire MSH6 gene using next-gen sequencing complemented by conventional Sanger sequencing or other molecular methodologies to detect point mutations, small…
Molecular
MYD88 Mutation Analysis Bi-directional sequencing of exon 5 of the MYD88 gene which includes detection of the common L265P mutation. Testing is approved for specimens from the state of New York.
Molecular
NeoARRAY™ SNP/Cytogenetic Profile The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage available, this test employs an enhanced SNP…
Molecular
RCC1 In normal kidney, renal cell carcinoma (RCC1, gp200) is localized along the brush border of the proximal tubule. In other normal tissues, RCC is also localized along the luminal surfaces of breast…
Immunohistochemistry (IHC)
NeoLAB™ BTK Inhibitor Acquired Resistance Panel - Liquid Biopsy The NeoLAB™ BTK Inhibitor Acquired Resistance Panel is a blood test performed by modified properietary bi-directional sequencing of the BTK and PLC-gamma-2 genes using cell-free circulating tumor DNA…
Molecular
NeoLAB™ FLT3 Mutation Analysis - Liquid Biopsy Detection of internal tandem duplication and exon 20 tyrosine kinase domain (TKD) mutations using bidirectional sequencing. Positive results identify specific TKD mutations or report ITD results…
Molecular
Glutamine Synthetase Glutamine synthetase (GS) is strongly expressed in a majority of hepatocellular carcinoma, including cases of early HCC and low grade HCC.
Immunohistochemistry (IHC)
Napsin A Napsin A has a specific function in normal alveolar epithelium and is proposed to play a role in the proteolytic processing of surfactant precursors. Napsin A is reported to be predominantly…
Immunohistochemistry (IHC)
PD-L1 22C3 FDA (KEYTRUDA®) for NSCLC PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded…
Immunohistochemistry (IHC)
ROS1 ROS1 gene rearrangements are reported in 1% to 2% of lung adenocarcinomas and are associated with a response to the multi-targeted tyrosine kinase inhibitor crizotinib. ROS1 rearrangement can be…
Immunohistochemistry (IHC)
NeoLAB™ KRAS Mutation Analysis - Liquid Biopsy Bi-directional sequencing of exons 2 and 3 of the KRAS gene. High-sensitivity sequencing is used for enhanced detection of mutations in codons 12, 13, 59, and 61. Testing is performed on cell-free…
Molecular
Surfactant Pulmonary surfactant apoproteins play essential roles in keeping alveoli from collapsing at the end of expiration. SP-A is located mainly in type II pneumocytes and has been demonstrated in…
Immunohistochemistry (IHC)
NeoLAB™ Myeloid Disorders Profile - Liquid Biopsy This test is performed on cell-free DNA/RNA in peripheral blood plasma by sequencing the entire coding regions of the genes listed. ABL1, ASXL1, ATRX, BCOR, BCORL1, BRAF, CALR, CBL, CBLB, CBLC,…
Molecular
NeoLAB™ NPM1 Mutation Analysis - Liquid Biopsy PCR and fragment analysis of exon 12 of the NPM1 gene to detect small insertion mutations specific to AML. Positive results are reported quantitatively as percent abnormal DNA. Testing is performed…
Molecular
NeoLAB™ NRAS Mutation Analysis - Liquid Biopsy Bi-directional sequencing of NRAS exons 2 and 3 which includes sites of common activating mutations in codons 12, 13, 59, and 61. Testing is performed on cell-free plasma DNA/RNA to increase…
Molecular
NeoLAB™ PML-RARA Translocation, t(15;17) - Liquid Biopsy Real-time RT-PCR for quantitative detection of the t(15;17) PML-RARA fusion transcript using cell-free plasma DNA/RNA. Both long and short isoforms of the fusion transcript are detected.
Molecular
NeoTYPE® Lung Tumor Profile The NeoTYPE Lung Tumor Profile analyzes 30 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include summary…
Molecular
ALK Mutation Analysis Bi-directional Sanger sequencing of ALK is performed using PCR primers designed to target hotspot mutations in exons 23 and 25.
Molecular
NGS Comprehensive Sarcoma Fusion Profile The NGS Comprehensive Sarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect 134 different translocations relevant in sarcomas in the genes ALK, CAMTA1, CCNB3, CIC,…
Molecular
NGS Ewing Sarcoma Fusion Profile The NGS Ewing Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations relevant in Ewing's sarcoma in the gene EWSR1.
Molecular
NGS Non-Ewing Sarcoma Fusion Profile The NGS Non-Ewing Sarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations unrelated to Ewing's sarcoma in the genes ALK, CAMTA1, CCNB3, CIC, EPC1…
Molecular
NGS Pediatric Sarcoma Fusion Profile The NGS Pediatric Sarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations related to pediatric sarcomas in the genes ALK, EWSR1, FUS, GLI1, NTRK3…
Molecular
NGS Rhabdomyosarcoma Fusion Profile The NGS Rhabdomyosarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations related to rhabdomyosarcoma in the genes FOXO1, NCOA2, and TFE3.
Molecular
NTRK & RET NGS Fusion Profile The NTRK & RET NGS Fusion Profile is an RNA-based next-generation sequencing panel that detects translocations and fusions of the genes NTRK1, NTRK2, NTRK3 and RET with known and novel fusion…
Molecular
NOTCH1 Mutation Analysis Bi-directional sequencing of exons 26, 27, and 34 is performed for detection of sequence variant mutations. Testing can be performed on plasma when adequate leukemic cells are not available.
Molecular
NPM1 Mutation Analysis PCR and fragment analysis of exon 12 of the NPM1 gene to detect small insertion mutations specific to AML. Positive results are reported quantitatively as percent abnormal DNA. Testing may be…
Molecular
NRAS Mutation Analysis Bi-directional sequencing of NRAS exons 2 and 3 which includes sites of common activating mutations in codons 12, 13, 59, and 61. Testing is approved for specimens from the state of New York.
Molecular
PDGFRa Mutation Analysis Bi-directional sequencing of exons 12 and 18 of the PDGFRA (platelet-derived growth factor alpha) gene. These exons are mutation hotspots that account for the majority of PDGFRA mutations detected in…
Molecular
PIK3CA LDT Mutation Analysis by Sequencing Bi-directional sequencing of PIK3CA exons 1, 9, and 20 which are the most commonly-mutated regions of the gene.
Molecular
PLC-Gamma-2 Mutation Analysis Bi-directional sequencing to detect mutations in exons 19, 20, and 24, covering amino acid ranges W646 to S679, A681 to M743, and I839 to V860. Testing is available separately or in combination with…
Molecular
PML-RARA Translocation, t(15;17) Real-time RT-PCR for quantitative detection of the t(15;17) PML-RARA fusion transcript. Both long and short isoforms of the fusion transcript are detected. Positive results identify the isoform and…
Molecular
PMS2 Mutation & Del/Dup Analysis This test is performed by sequencing the entire PMS2 gene using next-gen sequencing complemented by conventional Sanger sequencing or other molecular methodologies to detect point mutations, small…
Molecular
PTEN Mutation Analysis Bi-directional sequencing of all exons (1-9) of the PTEN gene. For solid tumors, enrichment is performed before extraction. This assay does not detect large deletions.
Molecular
PTPN11 Mutation Analysis Bi-directional sequencing of exons 2-4 of PTPN11.
Molecular
EGFR T790M Germline Mutation Analysis Bidirectional sequence analysis of EGFR exon 20 in peripheral blood for detection of T790M germline mutation. Note: Patient and physician or genetic counselor signatures on the NeoGenomics Consent…
Molecular
RUNX1 Mutation Analysis Bi-directional sequencing of exons 4-10 of the RUNX1 gene
Molecular
MET Exon 14 Deletion Analysis MET Exon 14 Deletion Analysis is performed by real-time RT-PCR. The assay is designed to detect alternative splice junctions that lead to exon-skipping (deletion) of exon 14 of the gene MET. Note:…
Molecular
SETBP1 Mutation Analysis Bi-directional sequencing of the SETBP1 exon 4 mutation hotspot (covering amino acids 823-941). The locked nucleic acid (LNA) technique is used to increase detection sensitivity for mutations at D868…
Molecular
SF3B1 Mutation Analysis RT-PCR and bi-directional sequencing of exons 14-17 of the SF3B1 gene. More than 90% of reported mutations are detected in these exons. This test detects mutations present at 10-15% or more in a wild…
Molecular
SRSF2 Mutation Analysis Bi-directional sequencing of the mutation hotspot region in exon 1 of the SRSF2 gene corresponding to amino acids 57-120.
Molecular
STAT3 Mutation Analysis Bi-directional sequencing of STAT3 exons 13-21 encompassing the DNA binding and SH2 domains.
Molecular
T-Cell Receptor Beta Gene Rearrangement This test provides qualitative detection of monoclonal T-cell receptor (TCR) beta gene rearrangements by PCR and fragment analysis according to BIOMED-2 consensus primer design. This test may be…
Molecular
T-Cell Receptor Gamma Gene Rearrangement Detection of clonal T-cell receptor gamma (TCRG) gene rearrangements by PCR of variable and joining regions. T-Cell Receptor Beta Gene Rearrangement is offered separately and may be added to this…
Molecular
TET2 Mutation Analysis Bi-directional sequencing of the entire coding sequence of the TET2 transcript variant A (2002 amino acids in length).
Molecular
TP53 Mutation Analysis Bi-directional sequencing of TP53 exons 4-9.
Molecular
U2AF1 Mutation Analysis Bi-directional sequencing of exons 2 and 7 of the U2AF1 gene (also called U2AF35).
Molecular
UGT1A1 Genotyping Lengths of the TA repeat polymorphism in the promoter region of the UTG1A1 gene are determined by fragment analysis using capillary electrophoresis. The alleles detected include the common normal…
Molecular
BAP1 BAP1 IHC stain is a tool for detection of BAP1 mutations with subsequent inactivation. Loss of BAP1 by IHC is 100% specific for malignant mesothelioma in the context of mesothelioma vs. mesothelial…
Immunohistochemistry (IHC)
ZRSR2 Mutation Analysis Bi-directional sequencing of exons 5 and 7-11 of the ZRSR2 gene.
Molecular
CDKN2A (p16) Deletion for Mesothelioma Probes: CDKN2A (p16) (9p21) | Centromere 9Disease(s):  Mesothelioma
FISH
NeoTYPE Liposarcoma Fusion Profile The NeoTYPE Liposarcoma Fusion Profile combines next-generation sequencing to detect translocations in the genes EWSR1, FUS, HMGA2, and PLAG1 with FISH testing for MDM2 to detect amplifications…
Molecular
Oncomine™ Dx Target Test The Oncomine Dx Target Test is a next-gen sequencing assay designed to detect variants in 23 genes associated with non-small cell lung cancer (NSCLC). Abnormalities targeted are ROS1 gene fusions and…
Molecular
NeoTYPE® Ovarian Tumor Profile The NeoTYPE Ovarian Tumor Profile analyzes 29 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary…
Molecular
HER2 Breast This test uses the Ventana PATHWAY anti-HER-2/neu antibody (clone 4B5) for the semi-quantitative detection of HER-2 antigen in sections of FFPE normal and neoplastic tissue. The test is FDA-approved…
Immunohistochemistry (IHC)
BCR-ABL1 Non-Standard p230 Real-time RT-PCR for detection of t(9;22) BCR-ABL1 fusion transcripts that result in p230 fusion proteins. Analytical sensitivity is 1 tumor cell in 100,000 normal cells. BCR-ABL1 Standard p210, p190…
Molecular
TOPO1 Topoisomerase I (TOPO1)  is essential nuclear enzyme for replication and transcription during cell reproduction and DNA repair. Upregulation of TOPO1 increases with disease stage in colorectal and…
Immunohistochemistry (IHC)
Insulin Insulin is composed of a and b chains connected through the C-peptide. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as a marker of islet cell tumor…
Immunohistochemistry (IHC)
S100p Expression of S100P, a member of the S100 family, is increased in a number of tumors, including pancreas, lung, breast, and ovary carcinomas. S100P can be seen in many pancreatic ductal carcinoma,…
Immunohistochemistry (IHC)
TERT Promoter Mutation Analysis Bi-directional Sanger sequencing is performed using PCR primers designed to target mutations in the promoter region of TERT.
Molecular
Somatostatin Somatostatin is a useful marker of D-cells of pancreatic islet cells. D-cells are used to identify hyperplasia of the pancreatic islets. Most of these tumors are malignant, giving rise to…
Immunohistochemistry (IHC)
NeoTYPE® Pancreas Tumor Profile The NeoTYPE Pancreas Tumor Profile analyzes 31 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include…
Molecular
IgH Clonality/MRD by NGS The IgH Clonality/MRD by NGS assay detects clonal populations of B-lymphocytes in a given patient sample through the analysis of the VDJ segment of the immunoglobulin heavy chain (IgH) gene. *Note -…
Molecular
NKX3.1 NKX3.1 is a protein encoded by the NKX3.1 gene located on chromosome 8. NKX3.1 protein has been found to be positive in the vast majority of primary prostatic adenocarcinomas. NKX3.1 stains nuclei in…
Immunohistochemistry (IHC)
Plasma Cell Myeloma Prognostic FISH Panel (non-New York) Probes: 1p-, 1q+, iso(1q): CDKN2C (1p32), CKS1B (1q21) | FGFR3/IgH t(4;14) | CCND1/IgH t(11;14) | 13q- (13q14, 13q34) | IgH/MAF t(14;16) | IgH/MAFB t(14;20) |17p- (TP53 17p13.1, NF1 17q11.2) | …
FISH
P501S P501S protein, also called the prostein, is a type IIIa plasma membrane protein which is exclusively expressed in cells of normal and malignant prostate. P501S expression has not been detected in…
Immunohistochemistry (IHC)
P504S Expression of P504S protein, or Alpha-methylacyl-CoA Racemase (AMACR), is found in prostatic adenocarcinoma but not in benign prostatic tissue. It has also been found to stain premalignant lesions of…
Immunohistochemistry (IHC)
Parafibromin Complete absence of nuclear staining for parafibromin is diagnostic of parathyroid carcinoma or an HPT-JT-related tumor (hyperparathyroidism-jaw tumor syndrome).
Immunohistochemistry (IHC)
STAT6 STAT6 is a highly sensitive and specific immunohistochemical marker for solitary fibrous tumor (SFT) and can be helpful to distinguish this tumor type from histologic mimics.
Immunohistochemistry (IHC)
MUC4 MUC4 is useful in the identification of low-grade fibromyxoid sarcoma (LGFMS) and sclerosing epithelioid fibrosarcoma.
Immunohistochemistry (IHC)
NeoTYPE AITL/Peripheral T-Cell Lymphoma Profile The NeoTYPE AITL/Peripheral T-Cell Lymphoma Profile is performed by the sequencing of select exons in the genes IDH1, IDH2, DNMT3A, TET2 and RHOA
Molecular
Prostate Triple Stain The combination of p63 + CK HMW + P504S (PIN-4 cocktail) can be extremely useful for diagnosing prostatic intraepithelial neoplasia (PIN) and/or prostate carcinoma, especially in difficult cases with…
Immunohistochemistry (IHC)
PSA Prostate specific antigen (PSA) is a glycoprotein with a molecular weight of 33-34kDa. It is restricted to the cytoplasm of acinar and ductal epithelia of normal, benign or malignant prostate tissue…
Immunohistochemistry (IHC)
CLL/Mantle Cell Companion Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
CD4/CD8 Ratio for BAL Available as global test only for bronchoalveolar lavage (BAL) specimens. Markers are CD3, CD4, CD8, and CD45 (4 markers). This test is not for quantitative immune status monitoring. (Tech-only…
Flow Cytometry
T&B Tissue Flow Panel Stand-alone test. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD19, CD20, CD23, CD34, CD38, CD45, CD56, kappa, and lambda (17 markers). 
Flow Cytometry
Plasma Cell Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
PSAP/HPAP Prostate specific acid phosphatase/human prostatic acid phosphatse (PSAP/HPAP) is a 100kDa glycoprotein present in high concentration in the prostate gland and its secretions. PSAP is specific to the…
Immunohistochemistry (IHC)
PSMA Prostate specific membrane antigen (PSMA) is a 750 amino acid type II membrane glycoprotein with folate hydrolase and neuropeptidase activity. PSMA is expressed in normal and malignant prostatic…
Immunohistochemistry (IHC)
NRAS Exon 4 Mutation Analysis Bi-directional sequencing of NRAS exon 4 is performed using PCR primers designed to target hotspot mutations in codons 117 and 146, among other regions in exon 4. Testing is available separately or…
Molecular
HOXB13 Genotyping This test is performed on a patient's blood specimen to look for germline genetic variants. The method is bi-directional sequencing of exons 1 and 2 of the HOXB13 gene for detection of the G84E…
Molecular
HPV RNA ISH In situ hybridization on FFPE tissues for qualitative detection of E6/E7 mRNA in up to 28 HPV subtypes with the complete panel: low risk (10 subtypes: 6, 11, 40, 43, 44, 54, 69, 70, 71, 74) plus high…
In Situ Hybridization (ISH)
INI1 Lack of nuclear expression of INI1 is characteristic of malignant rhabdoid tumors and epithelioid sarcomas.
Immunohistochemistry (IHC)
COG Chromosome Analysis NeoGenomics is approved to perform chromosome analysis for the Children’s Oncology Group (COG). COG-protocol cytogenetics is performed on blood and bone marrow specimens in our Fort Myers, Florida…
Cytogenetics
Low-Grade/Small B-Cell Lymphoma FISH Panel Probes: BCL6 (3q27) | CCND1/IgH t(11;14) IgH/BCL2 t(14;18) | MALT1 (18q21) Probes may be ordered separately. Disease(s): NHL, B-Cell Lymphoma, MCL, follicular lymphoma, MZL, MALT lymphoma
FISH
RRM1 RRM1 is crucial for DNA synthesis and damage repair. High levels of RRM1 are associated with G2 cell cycle arrest and increased apoptosis in vitro.
Immunohistochemistry (IHC)
Androgen Receptor Mutation Analysis Bi-directional Sanger sequencing of the gene Androgen Receptor is performed using PCR primers designed to target hotspot mutations in exons 4, 5 and 8.
Molecular
HSD3B1 Genotyping Bi-directional Sanger sequencing is performed to detect the HSD3B1 (1245A>C) single nucleotide polymorphism (SNP). Inheritance of the HSD3B1 (1245C) allele, which enhances dihydrotestosterone…
Molecular
MAL MAL is a distinct molecular marker of primary mediastinal large B-cell lymphoma subtype among diffuse large B-cell lymphomas.
Immunohistochemistry (IHC)
NeoTYPE® GI Predictive Profile The NeoTYPE GI Predictive Profile analyzes 9 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include summary…
Molecular
PTH Parathyroid hormone (PTH) is expressed in normal parathyroid, parathyroid adenomas and primary and secondary hyperplasia of parathyroid. This antibody is useful in the differential diagnosis of…
Immunohistochemistry (IHC)
Thyroglobulin (TGB) This antibody labels thyroglobulin (TGB) in follicular epithelial cells of the thyroid and colloid. Thyroglobulin antibody is useful in positive identification of thyroid carcinomas of the papillary…
Immunohistochemistry (IHC)
NeoTYPE® Thyroid Profile The NeoTYPE® Thyroid Tumor Profile analyzes 21 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include…
Molecular
ZAP70 A prognostic factor in CLL/SLL.
Immunohistochemistry (IHC)
NUP98 Disease(s): Acute Myeloid LeukemiaProbes: NUP98 (11p15.4)
FISH
PPM1D Mutation Analysis PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent 1D) Mutation Analysis is performed by next-generation sequencing (NGS) of all coding regions of the PPM1D gene. Germline and somatic mutation testing…
Molecular
NeoTYPE® CLL Prognostic Profile This test is performed by the sequencing the entire coding regions of the genes MYD88, NOTCH1, SF3B1, and TP53 plus IgVH Mutation Analysis and the CLL FISH Panel as noted. Test orders include summary…
Molecular
IgVH Mutation Analysis RT-PCR and bi-directional sequencing of the variable region of the immunoglobulin heavy chain for detection of mutation from germline sequence. The mutated VH gene family is identified in positive…
Molecular
DUSP22-IRF4 Rearrangement Probes: DUPS22-IRF4 gene region at 6p25.3Disease(s): Anaplastic Large Cell Lymphoma (ALCL), large B-cell lymphoma  
FISH
High-Grade B-Cell Lymphoma Reflex FISH Panel (Non-New York) Probes: MYC (8q24). If rearranged, reflex to concurrent BCL2 (18q21) and BCL6 (3q27).Disease(s): B-cell lymphoma, double-hit lymphoma, triple-hit lymphoma Note: This test is available on a global…
FISH
CLL MRD Flow Panel Available as global test only. Markers are CD3, CD5, CD19, CD20, CD22, CD43, CD45, CD79b, and CD81 (9 markers).
Flow Cytometry
T-ALL Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
INSM1 INSM1 is a transcription factor that is a sensitive and specific marker for neuroendocrine tumors.  It is a nuclear stain, and is as good if not better than synaptophysin and is superior to…
Immunohistochemistry (IHC)
Sezary T-Cell Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
PD-L1 22C3 FDA (KEYTRUDA®) for Cervical PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded…
Immunohistochemistry (IHC)
Iron Special stain. This iron stain is used to detect and identify ferric (Fe3+) iron in tissue preparations, blood smears, or bone marrow smears. Minute amounts of ferric acid are commonly found in bone…
Immunohistochemistry (IHC)
BCL10 BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It is also a substrate for MALT1. Mutations in the gene can lead to…
Immunohistochemistry (IHC)
B-ALL MRD Flow Panel Available as global test only. Markers are CD3, CD9, CD10, CD13/CD33, CD19, CD20, CD34, CD38, CD45, CD58, CD71, and Syto16 (13 markers; Syto16 is not reported). This panel can detect MRD at the 0.01…
Flow Cytometry
TP63 Rearrangement Probes: TP63 (3q28) | TBL1XR1/TP63 [inv(3)(q26q28)] Disease(s): Anaplastic large cell lymphoma (ALCL), peripheral T-cell lymphoma (PTCL) Note: Probes are not orderable separately; concurrent…
FISH
ICOS ICOS (Inducible Co-Stimulator, CD278) is a member of the CD28 family that regulates T-cell activity and immune responses. ICOS is primarily expressed on activated CD4+ and CD8+ T-cells. It plays an…
Immunohistochemistry (IHC)
NGFR Nerve Growth Factor Receptor (NGFR), also known as P75NTR or CD271, is a neurotrophin receptor belonging to the tumor necrosis factor receptor family. NGFR is expressed mainly in Schwann cells and…
Immunohistochemistry (IHC)
Amyloid A & Amyloid P Amyloid A and P react with amyloid deposits in many tissues. When accompanied by Congo Red, Amyloid A and P can be used to distinguish primary and secondary amyloidosis. Because these stains are…
Immunohistochemistry (IHC)
PD-L1 SP142 FDA (TECENTRIQ®) for NSCLC The VENTANA PD-L1 (SP142) Assay is a qualitative immunohistochemical assay using rabbit monoclonal anti-PD-L1 clone SP142 intended for use in the assessment of the PD-L1 protein in formalin-fixed,…
Immunohistochemistry (IHC)
PD-L1 SP142 FDA (TECENTRIQ®) for Urothelial Carcinoma The VENTANA PD-L1 (SP142) Assay is a qualitative immunohistochemical assay using rabbit monoclonal anti-PD-L1 clone SP142 intended for use in the assessment of the PD-L1 protein in formalin-fixed,…
Immunohistochemistry (IHC)
11q Aberration in NHL Probes: CEN 11 (11p11.1-q11) | MLL (11q23) | 11qTel (11q25)Disease(s): B-cell non-Hodgkin lymphoma
FISH
CancerTYPE ID® with reflex to NeoTYPE® Cancer Profile CancerTYPE ID is a proprietary molecular cancer classifier used to identify unknown or unclear tumor types and subtypes in patients with metastatic cancer. When ordered through NeoGenomics,…
Molecular
PD-L1 22C3 FDA (KEYTRUDA®) for Urothelial Carcinoma PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded…
Immunohistochemistry (IHC)
BCL2 (SP66) BCL2 is a protein associated with apoptosis regulation produced by the BCL2 gene and is comprised of an alpha and beta chain. BCL2 (clone SP66) shows negative reaction on reactive germinal centers…
Immunohistochemistry (IHC)
NTRK NGS Fusion Profile The NTRK NGS Fusion Profile is an RNA-based next-generation sequencing panel that detects translocations and fusions of the Neurotrophic Tropomyosin-Related Kinase (NTRK) genes NTRK1, NTRK2, and…
Molecular
Lung NGS Fusion Profile The Lung NGS Fusion Profile is an RNA-based next-generation sequencing panel that detects translocations and fusions of the genes ALK, NTRK1, NTRK2, NTRK3, RET and ROS1 with known and novel fusion…
Molecular
CD52 Analysis Available as global and tech-only. Available as stand-alone test (as described here) or as add-on to panels. Markers are CD3, CD19, CD45, and CD52. Additional markers may be necessary to identify a…
Flow Cytometry
ALL Fusion Profile Detection of gene fusion transcripts in Acute Lymphoblastic Leukemia (ALL) from ribonucleic acid (RNA). RNA is isolated from bone marrow aspirates or peripheral blood and the cDNA sequence of…
Molecular
ALL FISH Profile (Ph-Like) Probes: PDGFRb (5q32), BCR/ABL1-ASS1 t(9;22), JAK2 (9p24.1), EPOR (19p13.2) and CRLF2 (Xp22.33/Yp11.32) are included in the ALL FISH (Ph-like) Profile. Probes may be ordered separately. Disease(s):…
FISH
Albumin RNA ISH Albumin RNA ISH is a sensitive and specific tool for distinguishing primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma from metastatic adenocarcinoma to the liver or carcinoma of…
In Situ Hybridization (ISH)
NUT Expression of nuclear protein in testis (NUT) is generally confined to the germ cells of the testis and ovary. NUT midline carcinomas are aggressive tumors with non-diagnostic morphology that…
Immunohistochemistry (IHC)
PD-L1 SP142 FDA (TECENTRIQ®) for TNBC (Breast) The VENTANA PD-L1 (SP142) Assay is a qualitative immunohistochemical assay using rabbit monoclonal anti-PD-L1 clone SP142 intended for use in the assessment of the PD-L1 protein in formalin-fixed,…
Immunohistochemistry (IHC)
PIK3CA CDx Mutation Analysis by PCR PIK3CA CDx Mutation Analysis by PCR is an FDA-approved qualitative companion diagnostic assay performed on DNA extracted from FFPE breast tissue to detect 11 mutations in exons 7, 9, and 20 of the…
Molecular
FGFR CDx Molecular Analysis FGFR CDx Molecular Analysis is a qualitative RT-PCR assay, FDA-approved for detection of four point mutations in the FGFR3 gene (p.R248C, p.S249C, p.G370C and p.Y373C) and two FGFR3 fusions (FGFR3:…
Molecular
NeoTYPE® GIST and Soft Tissue Tumor Profile The NeoTYPE® GIST/Soft Tissue Tumor Profile analyzes 35 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation…
Molecular
PD-L1 22C3 FDA (KEYTRUDA®) for HNSCC (Head & Neck) PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded…
Immunohistochemistry (IHC)
BRCA1/2 Mutation Analysis for Tumors BRCA1 and BRCA2 mutation analysis is performed by next-generation sequencing of all coding exons of the BRCA1 and BRCA2 genes to detect point mutations and small insertions/deletions. This test does…
Molecular