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Alternative Name
Philadelphia chromosome (Ph-like) acute lymphoblastic leukemia (ALL)| Ph-like ALL
Methodology
FISH
Test Description

Probes: PDGFRb (5q32), BCR/ABL1-ASS1 t(9;22), JAK2 (9p24.1), EPOR (19p13.2) and CRLF2 (Xp22.33/Yp11.32) are included in the ALL FISH (Ph-like) Panel. Probes may be ordered separately.
Disease(s): Philadelphia chromosome (Ph-like) acute lymphoblastic leukemia (ALL), B lymphoblastic leukemia/lymphoma.

Clinical Significance

The ALL FISH Panel (Ph-like) detects cytogenetic abnormalities commonly associated with Philadelphia chromosome (Ph-like) acute lymphoblastic leukemia (ALL). Patients with Ph-like B-ALL are associated with an unfavorable prognosis, but may potentially be amenable to inhibition with select tyrosine kinase inhibitors.

Specimen Requirements
  • Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.
  • Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
  • Fresh, Unfixed Tissue: Tissue in RPMI
  • Fluids: Equal parts RPMI to specimen volume
  • Paraffin Block or Cut Slides: Not Available
  • Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen

CPT Code(s)*
88374x5 automated or 88377x5 manual. Codes may differ if manual analysis is performed.
Turnaround Time

3-5 days

New York Approved
Yes
Level of Service
Global
Technical

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.