A ctDNA NGS liquid biopsy, testing 37 genes relevant to the care of advanced NSCLC patients
NeoLAB® Solid Tumor Liquid Biopsy
Rapid, high-quality NGS-based genomic profile for pan-cancer
NeoLAB® Heme Liquid Biopsy
Detection of critical biomarkers in patients with known and suspected hematologic cancers
About Liquid Biopsy
Liquid Biopsy refers to the analysis of blood by whole cancer cells (CTCs) or components of cells such as circulating tumor DNA (ctDNA) in order to characterize solid tumors. During the cancer lifecycle, DNA from our cancer cells break down and shed into the bloodstream, called circulating tumor DNA (ctDNA). From a simple blood draw, liquid biopsy testing can be performed to detect specific genetic variations in the ctDNA of a patient’s blood sample that may be causing the cancer to grow.
Liquid biopsy testing is a novel approach to genomic profiling and has shown to offer several advantages over tissue biopsy for select clinical scenarios. In the case of limited or insufficient tumor tissue or when a repeat biopsy is required for treatment monitoring, liquid biopsy may be a good option for patients largely because it is a minimally invasive procedure. Additionally, the location of the tumor may be difficult or even dangerous to contact for biopsy and testing of ctDNA by a blood draw might be a suitable alternative to traditional tissue biopsy. Lastly, liquid biopsy testing accounts for potential tumor evolution and heterogeneity since the ctDNA comes from cells anywhere in the body, whereas tissue biopsy is a sample taken from an isolated tumor.
Liquid biopsy testing has distinct attributes that can help overcome the limitations of tissue testing and help inform precision oncology decisions. Due to its faster turnaround time, less invasive procedure and it’s ease of use for serial testing, liquid biopsy testing may be an effective approach in the following settings:
- Inform treatment strategies
- Monitor disease progression
- Evaluate therapeutic effectiveness
- Tissue biopsy is the ‘gold standard’ biospecimen that can provide high diagnostic certainty, but there are characteristic limitations related to difficult biopsy locations, inadequate or insufficient tissue for molecular testing and tumor heterogeneity.
- Liquid biopsy testing is a minimally invasive approach to detect tumor-derived alterations and tumor heterogeneity. It’s also representative of multiple tumor foci and is an effective and efficient method to simultaneously detect genomic aberrations. Disadvantages to liquid biopsy include its inability to detect the location of tumor mutations, and the lack of diagnostic value if no mutations are detected.
- Tissue and liquid biopsy testing are complementary approaches and should be individualized for patient care.
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