Probes: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | 20q- (20q12, 20qter) | RUNX1/RUNX1T1 (ETO/AML1) t(8;21) | PML/RARA t(15;17) | CBFB inv(16), t(16;16)
Probes may be ordered separately except +8 and 20q- which are combined.
Disease(s): Acute myeloid leukemia
Note: STAT processing is available by request for PML-RARA. Note STAT along with MD contact name and phone number to receive STAT results.
The AML Standard FISH Panel identifies the most frequent cytogenetic abnormalities associated with favorable, intermediate, and poor risk. See also the AML Non-Favorable Risk Panel and the AML Favorable-Risk Panel.
- Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
- Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
- Fresh, Unfixed Tissue: Tissue in RPMI.
- Fluids: Equal parts RPMI to specimen volume.
- Paraffin Block or Cut Slides: Not available.
- Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
3-5 days. STAT results for PML-RARA, when requested, are reported 12-24 hours from receipt in the NeoGenomics laboratory