Alternative Name
Anaplastic lymphoma kinase
Methodology
FISH
Test Description
Probes: ALK (2p23)
Disease(s): Non-small cell lung carcinoma (NSCLC)
Clinical Significance
ALK gene rearrangements are found in 3-5% of non-small cell lung carcinoma (NSCLC) and determine likelihood of response to crizotinib (Xalkori®) therapy.
Specimen Requirements
- Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.
- Cut Slides: H&E slide (required) plus 2 unstained slides cut at 4 microns. Circle H&E for tech-only.
Storage & Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88377x1 manual.
Turnaround Time
3-5 days
Level of Service
Global
Technical
New York Approved
Yes