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Alternative Name
Anaplastic lymphoma kinase
Test Description

Probes: ALK (2p23)
Disease(s): Non-small cell lung carcinoma (NSCLC)

Clinical Significance

ALK gene rearrangements are found in 3-5% of non-small cell lung carcinoma (NSCLC) and determine likelihood of response to crizotinib (Xalkori®) therapy.

Specimen Requirements
  • Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.
  • Cut Slides: H&E slide (required) plus 2 unstained slides cut at 4 microns. Circle H&E for tech-only.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88377x1 manual.
New York Approved
Level of Service
Turnaround Time

3-5 days

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.