Probes: 1p36/1q25 |19q13/19p13
Ratios of p:q signals are determined for each chromosome to account for sectioning artifact. Deletion status is reported for each chromosome.
Testing for 1p and 19q deletions in glial brain tumors, specifically oligodendrogliomas, has diagnostic and prognostic value. Large or whole-arm deletions of chromosomes 1p and 19q are highly specific for oligodendroglioma tumors. Testing is useful to distinguish the oligodendroglioma subtype of diffuse gliomas from astrocytomas and from other tumor types with similar morphology such as clear cell ependyomas, central or extraventricular neurocytomas, and dysembryoplastic neuroepithelial tumors (DNETs). Codeletion of both the 1p and 19q regions in adult oligodendroglioma patients is associated with improved response and longer survival in patients receiving radiation and/or chemotherapy.
- Paraffin Block: Send paraffin block. Also send circled H&E slide for tech-only (required).
- Cut Slides: Send 4 unstained slides cut at 4-5 microns plus H&E slide (required). Circle H&E slide for tech-only.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
88374x2 automated or 88377x2 manual. Codes may differ if manual analysis is performed.