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Alternative Name
Acute myeloid leukemia
Test Description

Probes: RPN1, MECOM (3q21, 3q26.2) | 5q-, -5 (5p15, 5q31, 5q33 | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | DEK/NUP214 (CAN) t(6;9) | MLL (11q23) | ETV6 (12p13) | 17p- (TP53 17p13.1, NF1 17q11.2) | Probes may be ordered separately.
Disease(s):Acute myeloid leukemia

Clinical Significance

The AML Non-Favorable Risk FISH Panel accommodates US and international cytogenetic risk classifications for intermediate and adverse risk groups. This Panel was formerly called AML Extended Panel.

Specimen Requirements
  • Bone marrow aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
  • Peripheral blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
  • Fresh, unfixed tissue: Tissue in RPMI.
  • Fluids: Equal parts RPMI to specimen volume.
  • Paraffin block or cut slides: Not available.
  • Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Storage and Transportation

Refrigerate specimen. Do not freeze. Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88374x8 automated. Codes may differ if manual analysis is performed.
New York Approved
Level of Service
Turnaround Time

3-5 days

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.