Alternative Name
Acute lymphoblastic leukemia
Methodology
FISH
Test Description

Probes: TCF3/PBX1 (E2A/PBX1) t(1;19) | Trisomy or Tetrasomy 4, 6, 10, 17 (Cen 4, Cen 6, Cen 10, Cen 17) | MYC (8q24) | BCR/ABL1/ASS1 t(9;22) | MLL (11q23) | IgH (14q32) |
Disease(s): Acute lymphoblastic (lymphocytic) leukemia (B-cell ALL), B lymphoblastic lymphoma (LBL), adult
Probes may be ordered separately except Centromeres 4 and 17 are paired, and Centromeres 6 and 10 are paired.
Note: STAT processing is available by request for BCR-ABL1. Note STAT along with MD contact name and phone number to receive STAT results.
Note: CDKN2A (p16) Deletion FISH is also available and may be ordered separately. See details here.

Clinical Significance

The ALL Adult FISH Panel is used for the detection of recurrent chromosome abnormalities observed in adults with ALL of B-cell lineage and B lymphoblastic lymphoma (LBL). Identification of specific abnormalities helps predict disease aggressiveness and response to therapy. This panel differs from the ALL Pediatric FISH Panel in that this panel excludes probes for ETV6/RUNX1 t(12;21).

Specimen Requirements
  • Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
  • Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
  • Fresh, Unfixed Tissue: Tissue in RPMI.
  • Fluids: Equal parts RPMI to specimen volume.
  • Paraffin Block or Cut Slides: Not available.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88374x7 automated. Codes may differ if manual analysis is performed.
Turnaround Time

3-5 days. STAT results for BCR-ABL1, when requested, are reported 12-24 hours from receipt in the NeoGenomics laboratory.

Level of Service
Global
Technical

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.