Add to Favorites
Alternative Name
Anaplastic lymphoma kinase, (2p23)
Test Description

Probes: ALK (2p23)
Disease(s): Anaplastic large cell lymphoma, NHL

Clinical Significance

ALK gene rearrangements are associated with anaplastic large-cell lymphoma (ALCL), and patients with ALK-positive ALCL have a favorable prognosis compared to patients with ALK-negative ALCL. This FISH probe detects ALK gene rearrangements irrespective of the partner gene. This probe is available separately or as part of the NHL FISH Panel.

Specimen Requirements
  • Bone Marrow Aspirate: 1-2mL Sodium Heparin Tube. EDTA tube is acceptable
  • Peripheral Blood: 2-5mL Sodium Heparin Tube. EDTA tube is acceptable
  • Fresh, Unfixed Tissue: Tissue in RPMI
  • Fluids: Equal parts RPMI to specimen volume.
  • Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.
  • Cut Slides: H&E slide (required) plus 2 unstained slides cut at 4 microns. Circle H&E for tech-only.
  • Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Storage and Transportation

Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88377x1 manual. Codes may differ if automated analysis is performed.
New York Approved
Level of Service
Turnaround Time

4 days for both unfixed and FFPE specimens

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.