Cytogenetics

A cornerstone of cancer diagnostics

Cytogenetics is the study of normal and abnormal chromosomes in relation to disease. Sometimes called chromosome analysis or karyotyping, cytogenetic tests are used to gain diagnostic and prognostic insights regarding solid tumor cancers and hematologic malignancies, which can be the result of chromosome rearrangements or altered chromosome number (ploidy).

Our cytogenetic tests include a traditional G-banding for metaphase analysis with an added proprietary wet lab process that enhances the length of chromosomes, improving test resolution, making detection of chromosomal changes more reliable and ensuring you and your patients are getting the highest quality results.

Highlights of Our Cytogenetics Program

Industry-leading turnaround - Results on blood and bone marrow in 5 days

Standard and special specimens - Including solid tumor and POC

Extensive FISH library - For efficient case follow-up as needed

Automated metaphase identification - For improved efficiency and accuracy

Multi-stepped analysis - Two independent technologists + quality control for each case

Board-certified sign-off - For authoritative confirmation and results

Cytogenetics Testing

Bone marrow chromosome analysis is routinely done for diagnostic classification and/or determining prognosis of newly diagnosed leukemias. Concurrent peripheral blood studies may also be performed, while lymph nodes are preferred for most lymphomas. NeoGenomics has extensive experience with the difficult tissue culture and complex karyotypes that often accompany solid tumor cytogenetics. Highlights at NeoGenomics include:

  • karyotypes
  • metaphase spreads
  • ideograms
  • translocations, deletions and extra chromosomes
Cancer Cytogenetics

Quality cytogenetic studies remain a cornerstone of cancer diagnostics. While 2020 marked the 60-year anniversary of the first association of a chromosome abnormality with a specific cancer (the Philadelphia chromosome in CML), cancer cytogenetics have retained their unique value in hematologic and solid tumor cancers by providing whole genome assessments at the single-cell level. {extra text for SEO: Bone marrow chromosome analysis is routinely done for diagnostic classification and/or determining the prognosis of newly diagnosed leukemias. Concurrent peripheral blood studies may also be performed, while lymph nodes are preferred for most lymphomas. NeoGenomics has extensive experience with the difficult tissue culture and complex karyotypes that often accompany solid tumor cytogenetics. Highlights at NeoGenomics include:

  • 5-day turnaround time for blood and bone marrow analysis
  • Industry-leading in-house FISH probe library for efficient & comprehensive case follow-up in
  • hematologic neoplasms and solid tumors
  • Continuous workload optimization through bi-coastal and central laboratories, plus additional analysis only
  • “dry lab” sites
  • Fostering industry and employee growth with Florida state-approved technologist training program
Constitutional Cytogenetics

Pregnancy loss, congenital anomalies, and some cancer cytogenetics results can provide opportunities for constitutional cytogenetics. Higher resolution karyotypes can be produced in non-cancer constitutional (germline) chromosome analysis through the use of mitogens and synchronized culture times.  Services include:

  • Products of conception (POC) cytogenetics and/or parental blood studies
  • Routine and high-resolution cytogenetics for suspected chromosome abnormality
  • Follow-up of cancer cytogenetics to differentiate acquired vs. inherited abnormalities
  • STAT preliminary results for newborns by request

Prenatal (pregnancy/fetal) cytogenetics, chromosome breakage studies, and constitutional FISH studies are not available from NeoGenomics. Constitutional cytogenetics studies are performed through a seamless send-out process by Genetics Associates, Inc. in Nashville, TN.

Chromosomal Microarray Analysis (CMA)

Microarray provides molecular analysis of cytogenetic abnormalities at several times the level of resolution possible with chromosome analysis and it is effective with compromised and poorly or non-dividing tissues. Microarray testing using a high-density, FDA-cleared whole genome SNP array platform is performed on fresh (unfixed) specimens for constitutional studies as well as hematologic and solid tumor oncology studies. Applications include:

  • Clarification of complex karyotypes found especially in bone marrow and solid tumors
  • Diagnosis of molar pregnancy and ploidy determination
  • Use instead of cytogenetics for aged or contaminated POC specimens
  • Reflex testing after POC culture failure or normal POC chromosome analysis

Microarray testing is performed through a seamless send-out process by Genetics Associates, Inc. in Nashville, TN.

Client Services

NeoGenomics prides itself on our unparalleled customer support team. If you have questions regarding test information, specimen requirements, turnaround times, test add-on, and patient results, please feel free to reach out to a Client Services Advocate at client.services@neogenomics.com.

Cytogenetics Testing

View our full menu of available cytogenetics tests with printable descriptions and specimen requirements.

 

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