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In Situ Hybridization (ISH)
Test Description

Albumin RNA ISH is a sensitive and specific tool for distinguishing primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma from metastatic adenocarcinoma to the liver or carcinoma of unknown origin in formalin fixed paraffin-embedded tissues. Positive results in this assay provide evidence of liver origin.

Specimen Requirements
  • A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
  • One (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and three (3) positively charged unstained slides, all cut at 4-5 microns
  • Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition
Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

CPT Code(s)*
New York Approved
Level of Service
Stain Only
Turnaround Time

24 hours

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.