This test is performed on a patient's blood specimen to look for germline genetic variants. The method is bi-directional sequencing of exons 1 and 2 of the HOXB13 gene for detection of the G84E mutation and other variants of significance to prostate cancer risk. Note: Patient and physician or genetic counselor signatures on the NeoGenomics Consent for Hereditary Cancer Genetic Testing form are required. Testing will be put on hold until signatures are received.
HOXB13 mutations are associated with familial and early-onset prostate cancer. The G48E mutation has been associated with 10-20 times increased risk of prostate cancer. Testing should be considered for men with prostate hyperplasia and family history of prostate cancer. This test is not offered on tumors, as the frequency and significance of these mutations in tumors is not yet established.
- Peripheral blood: 5 mL in EDTA tube.
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.