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Alternative Name
Cytomegalovirus by ISH
In Situ Hybridization (ISH)
Test Description

In situ hybridization for detection of cytomegalovirus (CMV) RNA.

Clinical Significance

CMV is a herpesvirus capable of causing serious disease in immunocompromised / transplant patients and neonates. CMV ISH is useful for detection of primary, latent, and reactivated CMV infections in FFPE tissues.

Specimen Requirements
  • Cut Slides: 4 cut slides. Sections must be wrinkle and artifact-free. No additives in the water bath. Cut sections at 4-5 microns, and place tissue at the center bottom of a positively charged slide.
  • Paraffin block: Formalin-fixed paraffin-embedded tissue. Block should be sent with a cold pack. Block identifiers should be clearly written and match exactly with the specimen ID and the block labeling as noted on the requisition.
  • NOTE: Please also send one H&E slide with global testing and consult requests.
Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

CPT Code(s)*
New York Approved
Level of Service
Stain Only
Turnaround Time

48 hours

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.