Human fascin is a highly conserved actin-bundling protein. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative for staining. However, Reed-Sternberg cells in Hodgkin lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B-cells.
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
- One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.