Molecular
… through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A …
Molecular
… through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A …
Molecular
… through a combination of next-generation sequencing (NGS), and IHC as listed below. Test orders include summary … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A …
Molecular
… through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A …
Molecular
… through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be … specific tumors including brain, breast, colorectal, lung, thyroid, and others; please see separate listings for …
Molecular
… through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A …
Molecular
… through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A …
Molecular
… through a combination of next-generation sequencing (NGS) and IHC as listed below. Test orders include summary … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A …
Molecular
… through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A …
Molecular
… through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A …
Molecular
… through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include … IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A …
Molecular
… ™ - Solid Tumor is a broad, next-generation sequencing panel for pan-solid tumor indications. The assay detects … (InDels), copy number variants (CNV), and RNA fusions and splice variants in a total of 517 genes (517 … testing: ≥20% tumor and ≥10 mm² of tissue surface area for NGS (~500 tumor cells) (if PD-L1 is ordered, at least 100 …
Molecular
… (InDels), copy number variants (CNV), and RNA fusions and splice variants in a total of 50 genes (44 genes … are summarized and details provided for prognostic findings, therapy susceptibility or resistance, available … trials, and more. A microsatellite instability (MSI) NGS result of “indeterminate” will create a reflex to MSI by …
Molecular
… through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include … MET, Microsatellite Instability (MSI), NF1, NRAS, NTRK1 fusions, NTRK2 fusions, NTRK3 fusions, PDGFRA, PIK3CA, PTEN, … … 81445x1, 88377x2, 88360x1 … 24 … 26 … 28 … The NeoTYPE Thyroid Profile is useful to classify fine needle aspirates …
Immunohistochemistry (IHC)
… PTH Alternative Name Parathyroid Hormone Methodology Immunohistochemistry (IHC) Test Description Parathyroid hormone (PTH) is expressed in normal parathyroid, parathyroid adenomas and primary and secondary …
Immunohistochemistry (IHC)
… pancreatic acini, pituitary acini, pneumocytes, prostate, thyroid, skin (positive on the basal layer and negative on … ovarian, hepatocellular (HCC), colorectal CA, stomach and thyroid. It is negative in certain normal tissues, including … lymphomas, primitive neuroectodermal tumors (PNET)/Ewings and gastrointestinal stromal tumors (GIST). Positivity …
Immunohistochemistry (IHC)
… TSH Alternative Name Thyroid Stimulating Hormone Methodology Immunohistochemistry (IHC) Test Description Thyroid Stimulating Hormone (TSH) is a pituitary hormone of 28 kDa that stimulates thyroid growth and production of thyroid hormones. This …
Immunohistochemistry (IHC)
… TTF1 Alternative Name Thyroid Transcription Factory Methodology Immunohistochemistry (IHC) Test Description Thyroid Transcription Factory (TTF1) is found is found predominantly in lung and thyroid neoplasms. The utility of TTF1 becomes apparent in …
FISH
… Description Probes: RET (10q11.2) Disease(s): Lung cancer, thyroid cancer Clinical Significance RET gene rearrangements that result in growth-promoting chimeric or fusion proteins are found in 1-2% of … cell lung cancer (NSCLC) and 20-40% of sporadic papillary thyroid carcinoma (PTC). In lung cancer, the most common …
Immunohistochemistry (IHC)
… of nuclear staining for parafibromin is diagnostic of parathyroid carcinoma or an HPT-JT-related tumor (hyperparathyroidism-jaw tumor syndrome). Specimen Requirements A … of nuclear staining for parafibromin is diagnostic of parathyroid carcinoma or an HPT-JT-related tumor …
Molecular
… DNA & RNA - Brain uses targeted next-generation sequencing (NGS) to detect single nucleotide variants, insertions/deletions, and gene fusions in 83 unique genes (62 genes analyzed by DNA and 28 … clinical trial options. A microsatellite instability NGS result of “indeterminate” will create a reflex to MSI by …
FISH
… Description Probes: BRAF (7q34) Disease(s): Brain cancer, thyroid cancer, melanoma Clinical Significance This test … uses a break-apart BRAF probe to detect the BRAF-KIAA1549 fusion common in low-grade astrocytomas and to detect any … a positive trend. BRAF translocations have been reported in thyroid cancer and melanoma but are infrequent. MEK …
Immunohistochemistry (IHC)
… thyroglobulin (TGB) in follicular epithelial cells of the thyroid and colloid. Thyroglobulin antibody is useful in positive identification of thyroid carcinomas of the papillary and follicular types. … of thyroglobulin in a metastatic lesion establishes the thyroid origin of the tumor. Specimen Requirements A …
Immunohistochemistry (IHC)
… (IHC) Test Description Calcitonin is secreted by thyroidal parafollicular cells of neuroectodermal origin, … (1) For identification of early or microscopic medullary thyroid cancer (MTC), (2) To identify an MTC in the absence … MTC with microfollicular or papillary patterns from thyroid follicular and papillary neoplasms and (5) To …
Immunohistochemistry (IHC)
… of NTRK protein overexpression caused by gene fusions. Correlation of IHC staining with molecular detection of TRK fusions is moderate; discrepant cases have been described. … NTRK fusion frequencies (5-25%) include papillary thyroid cancer (PTC), GIST without KIT/PDGFRA/RAS mutations, …