NeoTYPE® Lung Tumor Profile

  • Next Generation Sequencing (NGS)

The NeoTYPE Lung Tumor Profile analyzes 49 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include summary interpretation of all results to help guide treatment decisions. If global HER2 (Other) IHC w/Breast Scoring result is 2+, case will reflex to global HER2 (Other) FISH w/Breast Scoring unless reflex to tech-only FISH or reflex opt-out is requested. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (40 genes + 2 biomarkers): AKT1, ALK, ARID1A, ATM, ATR, ATRX, BRAF, CCND1, CDKN2A, CDKN2B, EGFR, ERBB2, ERBB4, FBXW7, FGFR1, FGFR2, FGFR3, KEAP1, KIT, KMT2D, KRAS (includes G12C mutation), MET, Microsatellite Instability (MSI), NF1, NFE2L2, NOTCH1, NRAS, PDGFRA, PIK3CA, PTEN, RB1, RBM10, RET, ROS1, SMARCA4, SMAD4, SMO, SRC, STK11, TERT Promoter, TP53, Tumor Mutation Burden (TMB) Other Molecular (1 biomarker): MET Exon 14 Deletion Analysis FISH (5 biomarkers): ALK, MET, PTEN, RET, ROS1 (tech-only available) IHC (3 biomarkers): HER2 (Other) IHC w/Breast Scoring, PD-L1 22C3, Pan-TRK (tech-only available for HER2 and PD-L1).

Turnaround time
14 Days

Level of Service

  • Global
New York Approved: No

Specimen Requirements

FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.

Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*

81457x1, 88377x5, 88360x2, 88342x1; add 88374x1 if HER2 IHC is reflexed to FISH; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

Last Updated: March 05, 2025

Get in touch

Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.