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Alternative Name
PI3K Mutation Analysis
Test Description

Bi-directional sequencing of PIK3CA exons 1, 9, and 20 which are the most commonly-mutated regions of the gene.

Clinical Significance

The PIK3CA gene encodes the p110 alpha catalytic subunit of PI3K enzymes. Mutations occur in a wide variety of tumors and may have prognostic and therapeutic significance, depending on tumor type. Numerous PI3K-pathway inhibitors are in development.

Specimen Requirements
  • FFPE solid tumor tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
Prior to 12/31/2019 CPT Code 81404; as of 01/01/2020 CPT Code 81309
Turnaround Time

10 days

Level of Service

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.