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Alternative Name
Thyroid Profile
Methodology
Molecular
Test Description

The NeoTYPE Thyroid Tumor Profile analyzes 32 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, NTRK NGS Fusion Profile for NTRK1 fusions, NTRK2 fusions, and NTRK3 fusions will be added by reflex.

  • NGS (26 genes + 2 biomarkers): AKT1, ALK, ARID1A, ATM, BRAF, CDKN2A, CTNNB1, ERBB2, ERBB4, HRAS, KRAS, MEN1, MET, Microsatellite Instability (MSI), NF1, NF2, NRAS, PIK3CA, PTEN, RET, SMAD4, SMO, SRC, TERT Promoter, TP53, TSC1, TSC2, Tumor Mutation Burden (TMB)

  • FISH (2 FISH): MET, RET (tech-only available)

  • IHC (2 biomarkers): PD-L1 22C3, Pan-TRK (tech-only available for PD-L1)

Clinical Significance

The NeoTYPE Thyroid Profile is useful to classify fine needle aspirates of thyroid nodules that are indeterminate or suspicious on cytology. Presence of mutations or gene rearrangements as detected by FISH predicts malignancy with varying degrees of specificity depending on the gene mutated and histological subtype. BRAF mutation V600E is associated with poor prognosis in papillary thyroid carcinoma (PTC).

Specimen Requirements
  • FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. All slides can be packed at room temperature.

CPT Code(s)*
81479x1, 88377x2, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Profile
Turnaround Time

14 days

Level of Service
Global

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.