Angioimmunoblastic/Peripheral T-Cell Lymphoma Profile
The NeoTYPE AITL/Peripheral T-Cell Lymphoma Profile is performed by the sequencing of select exons in the genes IDH1, IDH2, DNMT3A, TET2 and RHOA
Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma (PTCL) and accounts for 20-25% of PTCLs. Peripheral T-cell lymphoma is known as an aggressive group of lymphoid malignancies and represent about 10-15% of non-Hodgkin lymphomas. Frequent mutations have been detected in the genes IDH1/2, DNMT3A, TET2 and RHOA in patients diagnosed with AITL. These mutations may play a role in the pathogenesis of AITL/PTCLs.
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible; specimens <72 hours old preferred.