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Alternative Name
Myeloproliferative Neoplasms Extended Reflex Panel
Test Description

Sequential testing panel including qualitative detection of JAK2 V617F, JAK2 Exon 12-14, CALR exon 9, and MPL exon 10. Testing proceeds by reflex through the four-step panel until a mutation is identified, when the result is considered informative and no further testing is performed. Testing is performed on plasma for increased sensitivity whenever possible. Tests may also be ordered individually (see separate listing). Testing is approved for specimens from the state of New York. 

Clinical Significance

Comprehensive testing to identify mutations associated with the myeloproliferative neoplasms polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Mutation analysis helps differentiate reactive conditions from MPNs, may provide prognostic information, and may help distinguish ET and PMF from PV.

Specimen Requirements
  • Peripheral blood: 5 mL in EDTA tube.
  • Bone marrow: 2 mL in EDTA tube.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible; specimens <72 hours old preferred.

CPT Code(s)*
81270, 81279, 81219, 81339 (as of 01/01/2021); Prior CPT Codes were 81270, 81403, 81219, 81402
Medicare MolDX CPT Code(s)*
New York Approved
Level of Service
Turnaround Time

10 days

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.