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Alternative Name
HER2 neu
Methodology
FISH
Test Description

Probes: HER2 (17q11.2-q12) | 17 (Cen 17)
Disease(s): Gastric cancer, gastroesophageal junction (GEJ) cancer, esophageal adenocarcinoma, and others

Clinical Significance

Determines anti-HER2 therapy.

Specimen Requirements
  • Pathology Report: A copy of the pathology report is required for HER2 testing (global cases only).
  • IHC Report with GEA Samples: For gastroesophageal specimens submitted for global HER2 Non-Breast FISH, we require a copy of the HER2 IHC report (if it is not available to us in NeoLINK™) so that we may interpret FISH results using 2016 CAP/ASCP/ASCO guidelines. Client Services will call your office or lab for missing IHC reports.
  • Bone Marrow Aspirate: N/A
  • Peripheral Blood: N/A
  • Fresh, Unfixed Tissue: N/A
  • Fluids: N/A
  • Paraffin Block: Send paraffin block. Also send circled H&E slide for tech-only (required).
  • Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only.
Storage and Transportation

Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88374x1 automated. Codes may differ if manual analysis is performed.
Turnaround Time

3-5 days

New York Approved
Yes
Level of Service
Global
Technical

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.