This cytokeratin cocktail can be useful in differentiation of the squamous cell carcinomas and adenocarcinomas. The 34bE12 clone recognizes cytokeratin (CK) 1, 5, 10 and 14. It is reactive with stratified epithelia, myoepithelial and basal cells of prostate and breast, and it stains squamous carcinomas and adenosquamous carcinomas (brown). Clone 5D3 recognizes cytokeratin (CK) 8 and 18 of all simple and glandular epithelium and adenocarcinomas (red).
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
- One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.