NCI Match

NeoGenomics is one of the designated laboratories in the NCI-MATCH trial.

What is NCI-MATCH?

The National Cancer Institute (NCI) and the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) co-developed the NCI Molecular Analysis for Therapy Choice (NCI-MATCH) study (also known as study EAY131). NCI-MATCH is a large precision medicine cancer trial with nearly 40 treatment arms exploring numerous genetic abnormalities and drugs in a large number of rare and common cancer types.


To determine whether certain drugs or drug combinations in adults whose tumors have specific genomic abnormalities will effectively treat their cancer, regardless of their cancer type.

Testing for Eligibility

Tumor gene testing by a designated lab is the only pathway for new patients to enroll into the trial. The laboratory referral process applies to eligible cancer patients who have their tumors genomically profiled by a designated laboratory at one of the nearly 1100 clinical sites across the United States. NeoGenomics is a designated laboratory for NCI-MATCH. NeoGenomics provides 19 different NeoTYPE® Solid Tumor Profiles that may qualify a patient for the study. There are two pan-tumor (broad) Profiles and 17 targeted (tumor-specific) Profiles as shown below. The NeoTYPE Discovery Profile is a common choice for clinical trial screening because it is our most comprehensive Profile, evaluating 323 genes by next-generation sequencing (NGS).

Trial ID

Primary ID EAY131
Secondary IDs NCI-2015-00054 ID NCT02465060

Broad Profiles

  • Discovery (323 genes)
  • Precision (46 genes)

Targeted Profiles

  • Brain
  • Breast
  • Cervical
  • Colorectal
  • Endometrial
  • Esophageal
  • Gastric
  • GI Predictive
  • GIST & Neck
  • Head & Neck
  • Liver/Biliary
  • Lung
  • Melanoma
  • Other Solid Tumor
  • Ovarian
  • Pancreas
  • Thyroid

Call Client Services to order a NeoTYPE® Solid Tumor Profile or to request historical review of NeoTYPE® Discovery Profile for potential NCI-MATCH eligibility at 866.776.5907, option 3.



NeoTYPE Cancer Profiles are Laboratory Developed Tests (LDTs) under the Clinical Laboratory Improvements Act (CLIA).

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