- Distinguished University Professor
- The John W. Wolfe Chair in Human Cancer Genetics
- The Ohio State University, Columbus, Ohio, USA
His research has revealed the variety of mutated genes involved in leukemias, lymphomas and other cancers. During the course of his career, he discovered the juxtaposition of the human immunoglobulin genes to the MYC oncogene, the deregulation of MYC in Burkitt lymphoma, the ALL1/MLL gene involved in acute leukemias, the TCL1 gene associated with T-cell leukemias, and cloned, named and characterized the BCL2 gene involved in follicular lymphoma. In 2002 he discovered the role of microRNA in the pathogenesis of human cancer and then demonstrated that microRNA dysregulation contributes to the pathogenesis of all tumors. His discoveries have led to revolutionary innovations in the development of novel and successful approaches to cancer prevention, diagnosis, monitoring and treatment, based on gene-target discovery, verification and rational drug development.
Dr. Croce is a member of the National Academy of Sciences, Institute of Medicine (National Academy of Medicine), American Academy of Arts and Sciences, an AAAS Fellow and Fellow of the AACR Academy. His awards and honors include: Outstanding Investigator Award, The National Institutes of Health; General Motors Cancer Research Foundation - Charles S. Mott Prize; Robert J. and Claire Pasarow Foundation Cancer Award; AACR-Pezkoller International Award for Cancer Research; G.H.A. Clowes Memorial Award; Albert Szent-Gy0rgyi Prize for Progress in Cancer Research; Health Prize of the Fund InBev-Baillet Latour, Leuven, Belgium; Dan David Prize, Dan David Foundation at Tel Aviv University, shared with Prof. Mary-Claire King and Prof. Bert Vogelstein, Joint ECDO-Cell Death & Differentiation Award. He is principal investigator on several federal research grants, has more than 1100 peer-reviewed, published research papers and an H index of 219.