Smooth muscle actin antibody binds to smooth muscle cells and myoepithelial cells. It stains the muscularis propria and muscularis mucosae of the gastrointestinal tract, the uterine myometrium, medial layer of blood vessels, myoepithelial cells of salivary glands and other organs. The antibody does not stain skeletal and cardiac muscle, endothelium, connective tissue, epithelium or nerve. The antibody can be used to identify smooth muscle tumors (leiomyomas and leiomyosarcomas).
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
- One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.