Probes: RREB1 (6p25) | MYC (8q24) | CDKN2A p16 (9p21) | Centromere 9 | CCND1 (11q13)
Read more about the NeoSITE Melanoma panel.
NeoSITE Melanoma is a second-generation FISH assay that aids diagnostic discrimination between nevi and melanoma by informing of chromosomal gains or losses in four regions predictive of malignancy. This probe set has been modified from the prior version to improve classification of morphologically borderline lesions and detection of spitzoid melanoma, to control for tetraploidy, and to include 8q24 and 9p21 markers.
- Paraffin Block: Send block. For tech-only testing, include H&E slide with target area circled (required).
- Cut Slides: Slides should be cut at 4 micron thickness. For global testing, send 5 unstained slides. For tech-only, send 4-5 unstained slides plus H&E slide with target area circled (required).
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.