NTRK Sponsored Testing Program

Bayer Sponsored Test4TRK Program to test NTRK gene fusions for patients (US-based ONLY) with MSI-H mCRC or RAIR DTC.

For questions, please contact our Client Services at 1.866.776.5907, option 3.

NeoGenomics is pleased to partner with Bayer on the Test4TRK Testing Program to facilitate Neurotrophic Tropomyosin Receptor Kinase (NTRK) testing for patients with radioactive iodine refractory differentiated thyroid carcinoma ( RAIR DTC) or patients with metastatic colorectal cancer (mCRC) with high Microsatellite Instability (MSI-H) status.

NTRK gene fusions are a class of oncogenes that have been associated with more aggressive cancer in a range of tumor types. Testing for NTRK gene fusions may help you better understand the primary driver of your patients’ cancer and identify potential treatment options. Learn more about NTRK gene fusions and NTRK testing at www.trkcancer.com.

Available exclusively through NeoGenomics, the Test4TRK Testing Program will cover the cost of testing, for US-based patients ONLY, regardless of results and treatment decisions.

All eligible patients will receive an RNA-based next-generation sequencing (NGS) test, NTRK NGS Fusion Profile. Patients with an adequate tumor tissue sample will also receive a Pan-Trk Immunohistochemistry (IHC) test.

Please review our linked Resources for full details. Completion of the Test4TRK Test Request Form is required for testing. We are looking forward to working with you to provide this important testing to your patients. And we welcome your questions and comments.

Enroll your patients in the testing program with only 3 easy steps:


Complete the Test4TRK Test Request Form. Download here.
Call NeoGenomics at 866.776.5907, option 3 for ordering supplies or submit the tissue sample directly to NeoGenomics along with the patient's completed form.
Results will be delivered using your preferred method of delivery within 14 days of receipt of the patient's sample.

Patients, please consult with your medical care team to discuss whether you are a candidate for testing.

Frequently Asked Questions for Healthcare Professionals

Test4TRK is a Bayer sponsored program offering laboratory testing for NTRK gene fusions (histology and molecular) to US-based eligible colorectal and thyroid cancer patients at no cost. The test results provide actionable information that may identify appropriate options for your patient.

Bayer will cover the full cost of the test (for US-based patients ONLY) regardless of the test results and treatment decision.

All eligible patients (US-based ONLY) who enroll and opt-in to Test4TRK will receive an RNA- based next-generation sequencing (NGS) based, NTRK NGS Fusion Profile, from NeoGenomics. Patients with an adequate tumor tissue sample will also receive a NeoGenomics Pan-Tropomyosin receptor kinase (TRK) Immunohistochemistry (IHC) test.

NeoGenomics offers NTK gene fusion testing on formalin-fixed paraffin-embedded (FFPE) tissue. The paraffin block is preferred.

Alternatively, for NGS, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives. For IHC, send one (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered.

Results will be sent to the ordering physician’s office or laboratory within 10-14 days after sample is received.

Any US-based patient with radioactive iodine refractory differentiated thyroid carcinoma (RAIR DTC) or metastatic colorectal cancer (mCRC) with high microsatellite instability (MSI-H) with adequate tumor tissue is eligible to enroll in the Test4TRK program to receive genomic cancer testing at no cost. Patients who have not previously undergone a biopsy may still enroll in the program but are responsible for working with their physician to extract a viable tumor specimen and cover any associated expenses.

Any US-based patient with MSI-H mCRC or RAIR DTC is eligible for Test4TRK regardless of insurance coverage.

There will be NO COST for US-based patients, healthcare providers or insurance companies for the NGS based or IHC test.

No bill will be sent to patients, healthcare providers or insurance companies who participate through this program. If a bill is received in error, please disregard or contact NeoGenomics at 866.776.5907, option 3.

Download the NTRK Sponsored Testing Form here or contact NeoGenomics at 866.776.5907, option 3 for supplies.

We are looking forward to working with you! Please contact NeoGenomics Client Services at 866.776.5907, option 3 to set-up your new account.


  1. Cocco, E. et al. Cancer Res. 2019;79(6):1047-1053. doi:10.1158/0008-5472.CAN-18-3126.