Alternative Name
T-Cell Gamma Gene Rearrangement, TCRG
Methodology
Molecular
Test Description
Detection of clonal T-cell receptor gamma (TCRG) gene rearrangements by PCR of variable and joining regions. T-Cell Receptor Beta Gene Rearrangement is offered separately and may be added to this gamma gene test.
Clinical Significance
Detects monoclonal T-cell receptor gamma gene rearrangement. Interpret in clinical context for diagnosis of T-cell lymphoproliferative disorders.
Specimen Requirements
- Peripheral blood: 5 mL in EDTA tube.
- Bone marrow: 2 mL in EDTA tube.
- FFPE tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 4-5 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
- Fresh tissue: Two pieces minimum, 0.2 cm^3 in RPMI. Note: not suitable for Freeze & Hold option.
- Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Note: Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.
Storage & Transportation
Refrigerate fresh tissue until shipping. For all specimens, use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
CPT Code(s)*
81342
Turnaround Time
7 days
Level of Service
Global
New York Approved
Yes