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Alternative Name
TP53 Gene Sequencing
Test Description

Bi-directional sequencing of TP53 exons 4-9.

Clinical Significance

TP53 mutations are detected in at least 50% of all adult tumors and are generally associated with a poor prognosis. The TP53 gene encodes the tumor suppressor p53. Germline mutations in TP53 are the cause of Li-Fraumeni Syndrome.

Specimen Requirements
  • Peripheral blood: 5 mL in EDTA tube.
  • Bone marrow: 2 mL in EDTA tube.
  • FFPE solid tumor tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
Turnaround Time

10 days

Level of Service

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.