Alternative Name
NHL FISH
Methodology
FISH
Test Description

Probes: ALK (2p23) | BCL6 (3q27) | MYC (8q24) | CCND1/IgH t(11;14) | IgH (14q32) | IgH/BCL2 t(14;18) | MALT1 (18q21)
Probes may be ordered separately.
Disease(s): NHL

Clinical Significance

The NHL FISH panel is used for the detection of chromosome aberrations observed in lymphoma.

Specimen Requirements
  • Bone Marrow Aspirate: 1-2mL Sodium Heparin Tube. EDTA tube is acceptable
  • Peripheral Blood: 2-5mL Sodium Heparin Tube. EDTA tube is acceptable
  • Fresh, Unfixed Tissue: Tissue in RPMI
  • Fluids: Equal parts RPMI to specimen volume.
  • Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.
  • Cut Slide: H&E slide (required) plus 12 unstained slides cut at 4 microns for panel, or 2 unstained slides cut at 4 microns for single abnormalities. Circle H&E for tech-only.
Storage and Transportation

Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88374x7 automated. Codes may differ if manual analysis is performed.
Turnaround Time

4 days

Level of Service
Global
Technical

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.