Alternative Name
Lymphoma Profile
Methodology
Molecular
Test Description
The NeoTYPE® Lymphoma Profile analyzes 12 genes through a combination of next-generation sequencing (NGS) and FISH as noted below. Test reports include a summary interpretation of all results together.
- NGS (12 Genes): BCL2, BCL6, BRAF, CARD11, CCND1 (BCL1), CD79B, EZH2, MYD88, NOTCH1, NOTCH2, NRAS, and TP53
- FISH (2 Genes): CCND1 (BCL1)/IgH t(11;14) | BCL2/IgH t(14;18)
Clinical Significance
Genes analyzed in this profile have known roles in lymphoma pathogenesis. Testing is useful for diagnosis, classification, prognosis, and treatment decisions. It is also useful to distinguish between activated B-cell-like (ABC) and germinal center (GC) subtypes, especially in diffuse large B-cell lymphoma (DLBCL).
Specimen Requirements
- Bone marrow (Preferred): 2 mL in EDTA tube.
- Peripheral blood: 5 mL in EDTA tube.
- FFPE tissue: Paraffin block. Alternatively, send 1 H&E slide plus 10-14 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative is the recommended fixative. Do not use zinc or mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note: Test in TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.
Storage & Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
CPT Code(s)*
81450x1; 88374x2 or 88377x2
Medicare MolDX CPT Code(s)*
81450
Turnaround Time
14 days
Level of Service
Global
New York Approved
No