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Alternative Name
Myelodysplastic syndrome
Methodology
FISH
Test Description

Probes: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | 20q- (20q12, 20qter)
Probes may be ordered separately except +8 and 20q- which are combined.
Disease(s): Myelodysplastic syndrome

Clinical Significance

The MDS Standard FISH Panel identifies the most frequent cytogenetic abnormalities associated with favorable, intermediate, and poor risk according to IPSS guidelines (since revised). See also the separate listing for MDS Extended FISH Panel which accommodates the 2012 IPSS-Revised classification.

Specimen Requirements
  • Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
  • Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
  • Fresh, Unfixed Tissue: Tissue in RPMI.
  • Fluids: Equal parts RPMI to specimen volume.
  • Paraffin Block or Cut Slides: Not available.
  • Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88374x4 automated. Codes may differ if manual analysis is performed.
New York Approved
Yes
Level of Service
Global
Technical
Turnaround Time

3-5 days

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.