Probes: IGL/MYC t(8;22)
Disease(s): B-cell lymphoma, double-hit lymphoma, triple-hit lymphoma
IGL/MYC translocation is observed recurrently in B-cell lymphomas, and when occurred concurrently with BCL2 and/or BCL6 rearrangement, is classified as double-hit/triple-hit lymphomas having a very poor prognosis.
- Bone Marrow Aspirate: N/A
- Peripheral Blood: N/A
- Fresh, Unfixed Tissue: N/A
- Fluids: N/A
- Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.
- Cut Slides: H&E slide (required) plus 2 unstained slides cut at 4 microns. Circle H&E for tech only.
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.