Methodology
Immunohistochemistry (IHC)
Test Description
The CD44 family of glycoproteins exists in a number of variant isoforms, including hematopoietic variant (CD44s) and epithelial cells variant (CD44v). While many human tumors express CD44, a positive correlation between increased CD44 expression and tumor progression has been demonstrated in only some. The most practical application of CD44 immunostaining at present is the discrimination of urothelial transitional cell carcinoma-in-situ from non-neoplastic changes in the urothelium.
Specimen Requirements
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
or - One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage & Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88342 x 1 or 88341 x 1
Turnaround Time
24 hours
Level of Service
Stain Only
New York Approved
Yes