ATRX mutations predominantly occur in grade II/III astrocytoma and secondary glioblastoma multiforme (GBM) brain tumors. ATRX loss defines a subgroup of astrocytic tumors with a favorable prognosis.
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
- One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Tech-Only (stain only): 24 hours
Global prognostic interpretation is available