NeoLAB

Cell-free NGS analysis for solid tumor cancers and hematologic diseases

NeoLab® Solid Tumor Liquid Biopsy is an NGS assay for pan-cancer that gives you a comprehensive, single order testing solution for solid tumors. It includes 44 genes involved in solid tumor development and progression, covering actionable markers supported by clinical guidelines and on-going clinical trials.

NeoLab® Heme Liquid Biopsy is a sizeable menu of non-invasive, cell-free circulating tumor DNA/RNA liquid biopsy assays for patients with leukemias and lymphomas. Our methods help identify a patient’s genomic footprint and provide disease monitoring with minimally invasive sample needs compared to painful and expensive bone marrow biopsies.

NeoLAB® Solid Tumor Liquid Biopsy Benefits

Pan-cancer tumor types (bladder, brain/CNS, breast, cervical, colorectal, stomach, head and neck, etc.)

Detects 900+ hotspot SNVs and indels across 44 genes

Accurate results are returned within 7 calendar days after sample is received

  • 98% accuracy, 95.1% sensitivity, 98.8% specificity
  • Limit of Detection: 0.1% allele fraction for indels; 0.15% for SNV
Clinical Applications
Clinical Significance Clinical icon
Identifying targetable alterations

Identify Targetable Alteration

Check List Clinical icon
Monitoring disease status

Monitor Disease Status

Microscope & Morphologyav Clinical icon
Detecting potential resistance

Detect Potential Resistance

Genes investigated

AKT1 ERBB3 HRAS NTRK3
ALK ESR1 IDH1 PDGFRA
APC FBXW7 IDH2 PIK3CA
AR FGFR1 KIT PTEN
ARAF FGFR2 KRAS RAF1
BRAF FGFR3 MAP2K1 RET
CHEK2 FGFR4 MAP2K2 ROS1
CTNNB1 FLT3 MET SF3B1
DDR2 GNA11 MTOR SMAD4
EGFR GNAQ NRAS SMO
ERBB2 GNAS NTRK1 TP53

NeoLAB® Heme Liquid Biopsy Benefits

Sensitive assessment of therapy effectiveness and disease progression

Allows more frequent monitoring due to non-invasive collection method

Plasma provides a homogeneous sample and removes the potential for missing patchy disease with marrow collection

Spares the patients an invasive, uncomfortable, and expensive procedure

Clinical Applications
NeoLAB Heme Clinical icon
Screening for diagnostic mutations

In suspected myeloid disorders to determine if BM biopsy is absolutely necessary

Check List Clinical icon
Monitoring disease status and response to therapy
Blood Draw Clinical icon
Bone marrow sample

Is inadequate (dry tap, insufficient quantity) or unavailable

Lab Coat Clinical icon
Bone marrow biopsy procedure

Is not optimal (bleeding tendency, fragile patients, pediatric patients)

NeoLAB®

AML Profile ASXL1, BRAF, CEBPA, DNMT3A, ETV6, FLT3, HRAS, IDH1, IDH2, JAK2 V617F, JAK2 Exon 12+14, KRAS, MLL, NPM1, NRAS, PDGFRA, PHF6, PML, PTPN11, RUNX1, SETBP1, TET2, TP53 and WT1
BTK Inhibitor Acquired Resistance Panel BTK, PLC-Gamma-2
MDS/CMML Profile ASXL1, BCOR, BCORL1, BRAF, CALR, CBL, CEBPA, DNMT3A, DDX41, ETV6, EZH2, FLT3, GATA2, HRAS, IDH1, IDH2, JAK2 V617F, JAK2 Exon 12+14, KIT, KRAS, MPL, NF1, NPM1, NRAS, PDGFRA, PPM1D, PTEN, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, STAG2, STAT3, TET2, TP53, U2AF1, ZRSR2
Myeloid Disorders Profile ABL1, ASXL1, ATRX, BCOR, BCORL1, BRAF, CALR, CBL, CBLB, CBLC, CDKN2A, CEBPA, CSF3R, CUX1, DDX41, DNMT3A, ETNK1, ETV6, EZH2, FBXW7, FLT3, GATA1, GATA2, GNAS, GNB1, HRAS, IDH1, IDH2, IKZF1, JAK2 V617F, JAK2 Exon 12+14, JAK3, KDM6A, KIT, KRAS, MLL, MPL, MYD88, NF1, NOTCH1, NPM1, NRAS, PDGFRA, PHF6, PML, PPM1D, PTEN, PTPN11, RAD21, RUNX1, SETBP1, SF3B1, SH2B3, SMC1A, SMC3, SRSF2, STAG2, STAT3, STAT5B, TET2, TP53, U2AF1, WT1, ZRSR2

 

Single Gene NeoLAB®

FLT3 Mutation Analysis KIT (c-KIT) Mutation Analysis
IDH1 Mutation Analysis NPM1 Mutation Analysis
IDH2 Mutation Analysis RUNX1-RUNX1T1 (AML1-ETO) Translocation, t(8;21)
Inv(16), CBFB-MYH11 Translocation  
Test Details

See complete test details for NeoLAB® Solid Tumor and Heme Liquid Biopsy.

Get a printable test description and specimen requirements.

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Mobile Phlebotomy Program

NeoGenomics is proud to offer in-home specimen collection for liquid biopsy assays through our national mobile phlebotomy program, providing safe and convenient blood draws for liquid biopsy with no added costs for patients.

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