Displaying 551 - 575 of 577
Probes: TOP2A (17q21-q22) | Cen 17 (17p11.1-q11.1)Disease(s): Breast cancerNote: Available as a global test only.
FISH
Topoisomerase I (TOPO1)  is essential nuclear enzyme for replication and transcription during cell reproduction and DNA repair. Upregulation of TOPO1 increases with disease stage in colorectal and pancreatic cancers.
Immunohistochemistry (IHC)
Toxoplasma is a crescent shaped sporozoan that lives as an intracellular parasite in various tissues of vertebrates and completes its life cycle in a single host. This antibody helps to identify the toxoplasma in FFPE tissues.
Immunohistochemistry (IHC)
Bi-directional sequencing of TP53 exons 4-9.
Molecular
Probes: TP63 (3q28) | TBL1XR1/TP63 [inv(3)(q26q28)] Disease(s): Anaplastic large cell lymphoma (ALCL), peripheral T-cell lymphoma (PTCL) Note: Probes are not orderable separately; concurrent analysis is necessary due to proximity of breakpoints in…
FISH
TRAP IHC is of use in the identification of hairy cell leukemia, but it is not a completely specific marker.
Immunohistochemistry (IHC)
Special stain. Trichrome stains are frequently used to differentiate between collagen and smooth muscle in tumors and to identify increases in collagenous tissue in diseases such as cirrhosis of the liver.
Immunohistochemistry (IHC)
This antibody labels a mast cell tryptase. It will also show reactivity to basophils, but to a lesser degree.
Immunohistochemistry (IHC)
Antibody MAB4130 recognizes a 36 kDa protein identified as Thymidylate Synthase [TS], which is a target for the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors. Expression of TS is associated with response to 5-fluorouracil…
Immunohistochemistry (IHC)
Thyroid Stimulating Hormone (TSH) is a pituitary hormone of 28 kDa that stimulates thyroid growth and production of thyroid hormones. This antibody labels thyrotropic cells of the pituitary and may be useful in the classification of pituitary…
Immunohistochemistry (IHC)
Thyroid Transcription Factory (TTF1) is found is found predominantly in lung and thyroid neoplasms.  The utility of TTF1 becomes apparent in the differential diagnosis of primary versus metastatic carcinomas, especially in the lung. This clone is…
Immunohistochemistry (IHC)
Mycobacterium tuberculosis is the most common cause of tuberculosis. Immunohistochemical demonstration of mycobacterial antigens is not only useful in establishing mycobacterial etiology, but can also be used as an alternative method to the…
Immunohistochemistry (IHC)
Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-…
Immunohistochemistry (IHC)
Lengths of the TA repeat polymorphism in the promoter region of the UTG1A1 gene are determined by fragment analysis using capillary electrophoresis. The alleles detected include the common normal allele *1 (with 6 TA repeats) and the common abnormal…
Molecular
Uroplakin II is a 15 kDa protein component of urothelial plaques. Uroplakin II mRNA was found in both bladder cancer tissues and peripheral blood of patients with primary and metastatic urothelial carcinoma of the bladder. Uroplakin II antibody […
Immunohistochemistry (IHC)
Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non-neoplastic urothelium, UPIII is expressed in the luminal surface plasmalemma of superficial (…
Immunohistochemistry (IHC)
Available as global test only. Markers are VB1, VB2, VB3, VB4, VB5.1, VB5.2, VB5.3, VB7.1, VB7.2, VB8, VB9, VB11, VB12, VB13.1, VB13.2, VB13.6, VB14, VB16, VB17, VB18, VB20, VB21.3, VB22, and VB23 (24 markers). Two additional T-cell markers are used…
Flow Cytometry
Varicella Zoster Virus (VZV), a member of the human herpes virus family, causes two distinct clinical manifestations: chickenpox and shingles. Primary VZV infection results in chickenpox (varicella), which may rarely result in complications…
Immunohistochemistry (IHC)
Vascular endothelial growth factor (VEGF) is a glycoprotein involved in angiogenesis that promotes tumor progression and metastasis. VEGF is a mitogen for vascular endothelial cells derived from arteries, veins and lymphatics, but it is devoid of…
Immunohistochemistry (IHC)
This antibody recognizes villin, a cytoskeletal filament protein of 58 kDa found in human renal epithelial cells. Villin antibody is useful for the study of gastrointestinal cells in normal and tumor tissues.
Immunohistochemistry (IHC)
Vimentin is the major intermediate filament in a variety of mesenchymal cells, including endothelial cells, all fibroblastic cells, macrophages, Sertoli cells, melanocytes, lymphocytes and ovarian granulosa cells. Vimentin is found in all types of…
Immunohistochemistry (IHC)
Special stain. Warthin Starry stain is intended to identify Helicobacter pylori in tissue samples.
Immunohistochemistry (IHC)
Cytochemical stain. The Wright Giemsa stain is used to stain peripheral blood and bone marrow smears for study of blood cell morphology.
Immunohistochemistry (IHC)
Wilms tumor susceptibility gene 1 protein (WT1) has diagnostic utility in the distinction of mesothelioma from adenocarcinoma in tissue sections of pleural tumors. WT1 diffusely stains most ovarian serous carcinomas and all Wilms tumors.
Immunohistochemistry (IHC)
Probes: Centromere X | DYZ1Disease(s): Sex-mismatched stem cell transplant
FISH