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T-cell receptor delta (TCR delta) is used as a phenotypic marker for TCR delta-expressing T-cells. TCR is a heterodimer composed of either alpha/beta or gamma/delta. TCR delta is expressed by thymocytes and a majority of peripheral (gamma/delta TCR-…
Immunohistochemistry (IHC)
T Cell Receptor beta (TCRβ) is used as a phenotypic marker for TCRβ expressing T-cells. TCRβ is expressed by thymocytes and a majority of peripheral (α/β TCR-bearing) T-cells. This antibody does not cross-react with γ/Δ TCR-bearing T-cells.
Immunohistochemistry (IHC)
TdT is a highly specific marker for the diagnosis and classification of acute lymphoblastic lymphoma/leukemias. The determination of TdT expression is most valuable when it is important to differentiate histologically between lymphoblastic lymphoma…
Immunohistochemistry (IHC)
Bi-directional Sanger sequencing is performed using PCR primers designed to target mutations in the promoter region of TERT.
Molecular
TET2 mutation analysis is performed by next-generation sequencing of all coding exons of the TET2 gene.
Molecular
Overexpression of TFE3 is a sensitive and specific marker of Xp11 translocation in renal cell carcinomas. TFE3 is also expressed in alveolar soft part sarcoma the hallmark of which is a chromosomal rearrangement at 17q25 and Xp11.2 engendering an…
Immunohistochemistry (IHC)
Thrombomodulin (TM) is a plasma membrane-related glycoprotein that has anticoagulant activity. TM antigen is found in several cell types, including megakaryocytes, mesangial cells, synovial cells, mesothelial cells, endothelial cells, and some…
Immunohistochemistry (IHC)
The THxID BRAF test is an FDA-approved, PCR-based qualitative companion diagnostic performed on DNA extracted from FFPE melanoma tissue for detection of two mutations in the BRAF gene: V600E (c.1799T>A) and V600K (c.1798_1799delinsAA).
Molecular
This antibody labels thyroglobulin (TGB) in follicular epithelial cells of the thyroid and colloid. Thyroglobulin antibody is useful in positive identification of thyroid carcinomas of the papillary and follicular types. Demonstration of…
Immunohistochemistry (IHC)
TIA1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. Most anaplastic large cell lymphomas react with TIA1. TIA1 also reacts…
Immunohistochemistry (IHC)
Expression of the transducing-like receptor (TLE) genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state. TLE1 antibody is an excellent discriminator of synovial…
Immunohistochemistry (IHC)
Probes: TOP2A (17q21-q22) | Cen 17 (17p11.1-q11.1) Disease(s): Breast cancer Note: Available as a global test only.
FISH
Topoisomerase I (TOPO1)  is essential nuclear enzyme for replication and transcription during cell reproduction and DNA repair. Upregulation of TOPO1 increases with disease stage in colorectal and pancreatic cancers.
Immunohistochemistry (IHC)
Toxoplasma is a crescent shaped sporozoan that lives as an intracellular parasite in various tissues of vertebrates and completes its life cycle in a single host. This antibody helps to identify the toxoplasma in FFPE tissues.
Immunohistochemistry (IHC)
Bi-directional sequencing of TP53 exons 4-9.
Molecular
Probes: TP63 (3q28) | TBL1XR1/TP63 [inv(3)(q26q28)] Disease(s): Anaplastic large cell lymphoma (ALCL), peripheral T-cell lymphoma (PTCL) Note: Probes are not orderable separately; concurrent analysis is necessary due to proximity of breakpoints in…
FISH
TRAP IHC is of use in the identification of hairy cell leukemia, but it is not a completely specific marker.
Immunohistochemistry (IHC)
Special stain. Trichrome stains are frequently used to differentiate between collagen and smooth muscle in tumors and to identify increases in collagenous tissue in diseases such as cirrhosis of the liver.
Immunohistochemistry (IHC)
This antibody labels a mast cell tryptase. It will also show reactivity to basophils, but to a lesser degree.
Immunohistochemistry (IHC)
Antibody MAB4130 recognizes a 36 kDa protein identified as Thymidylate Synthase [TS], which is a target for the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors. Expression of TS is associated with response to 5-fluorouracil…
Immunohistochemistry (IHC)
Thyroid Stimulating Hormone (TSH) is a pituitary hormone of 28 kDa that stimulates thyroid growth and production of thyroid hormones. This antibody labels thyrotropic cells of the pituitary and may be useful in the classification of pituitary…
Immunohistochemistry (IHC)
Thyroid Transcription Factory (TTF1) is found is found predominantly in lung and thyroid neoplasms.  The utility of TTF1 becomes apparent in the differential diagnosis of primary versus metastatic carcinomas, especially in the lung. This clone is…
Immunohistochemistry (IHC)
Mycobacterium tuberculosis is the most common cause of tuberculosis. Immunohistochemical demonstration of mycobacterial antigens is not only useful in establishing mycobacterial etiology, but can also be used as an alternative method to the…
Immunohistochemistry (IHC)
Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-…
Immunohistochemistry (IHC)
Lengths of the TA repeat polymorphism in the promoter region of the UTG1A1 gene are determined by fragment analysis using capillary electrophoresis. The alleles detected include the common normal allele *1 (with 6 TA repeats) and the common abnormal…
Molecular