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Bi-directional sequencing to detect the C481S mutation in exon 15 and other potential mutations within the amino acid range C464 to M509. Testing is available separately or in combination with PLC-gamma-2 in the BTK Inhibitor Acquired Resistance…
Molecular
CA125 reacts with most epithelial ovarian neoplasms of serous, endometrioid, clear cell and undifferentiated types. CA125 is a useful tumor marker for ovarian carcinomas; however, CA125 has also been described in other neoplasms such as seminal…
Immunohistochemistry (IHC)
In normal tissues, the CA19.9 antigen has been demonstrated in ductal epithelium of the breast, kidney, salivary gland, sweat glands, respiratory epithelium of the lung, colon epithelium, pancreatic acini and ducts, biliary epithelium in the liver…
Immunohistochemistry (IHC)
Calcitonin is secreted by thyroidal parafollicular cells of neuroectodermal origin, probably in response to hypercalcemia. The IHC demonstration of calcitonin is important: (1) For identification of early or microscopic medullary thyroid cancer (MTC…
Immunohistochemistry (IHC)
Special stain.
Immunohistochemistry (IHC)
Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction. Two closely related variants of human caldesmon have been identified. The h-caldesmon variant (120-150kDa) is predominantly expressed in smooth…
Immunohistochemistry (IHC)
Calponin, a calmodulin, is involved in the regulation of smooth muscle contraction. The expression of calponin is restricted to smooth muscle cells. Two isoforms of calponin exist with molecular weights of 34kDa and 29kDa. Expression of the 29kDa…
Immunohistochemistry (IHC)
Bi-directional sequencing of exon 9 of the CALR (calreticulin) gene with fragment length analysis for enhanced detection of low levels of insertion/deletion mutations.Testing is approved for specimens from the state of New York. Read more about the…
Molecular
Calretinin is the most specific and reproducible positive marker of epithelial mesothelioma. Calretinin is a calcium-binding protein similar to S100 protein. It is found in the central and peripheral nervous system and in a wide spectrum of non-…
Immunohistochemistry (IHC)
Anti-Cytokeratin (CAM 5.2) has a primary reactivity with human keratin proteins that correspond to Moll`s peptides #7 and #8, Mr 48 and 52 Kd. Cytokeratin 8 is present on secretory epithelia of normal human tissue but not on stratified squamous…
Immunohistochemistry (IHC)
CancerTYPE ID is a proprietary molecular cancer classifier used to identify unknown or unclear tumor types and subtypes in patients with metastatic cancer. When ordered through NeoGenomics, classification with CancerTYPE ID is followed by tumor…
Molecular
Carbonic anhydrase IX (CAIX) is a cell surface transmembrane protein, which is predominantly found in the gastrointestinal tract and gall bladder. The glandular regions of normal colon are reported to be negative, but in the case of adenocarcinoma,…
Immunohistochemistry (IHC)
Probes: CBFB inv(16), t(16;16) Disease(s): AML, AMML (AML-M4E)
FISH
Probes: CCND1/IgH t(11;14) Disease(s): Mantle cell lymphoma, NHL
FISH
CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is expressed in early lymphoid progenitors and normal germinal center cells. It is almost always present on the surface of precursor B-lymphoblastic and Burkitt lymphomas and…
Immunohistochemistry (IHC)
CD103 antibody reacts with the integrin subunit CD103 cell surface antigen, which is expressed in intraepithelial T-lymphocytes, hairy cell leukemia, enteropathy associated T-cell lymphoma, and some splenic marginal zone lymphomas. Staining…
Immunohistochemistry (IHC)
CD117 (cKit) is a transmembrane receptor tyrosine kinase. It is expressed in many tissues and cells, such as tissue mast cells, skin basal cells, melanocytes, breast glandular epithelial cells, dermal sweat gland, esophageal glands, testicular and…
Immunohistochemistry (IHC)
In normal cells, CD11c is expressed on activated CD4/CD8+ T cells, granulocytes, lymphocytes, macrophages, and NK cells. In diseased, cells, CD11c is detected on acute myeloid leukemia (AML)-M4 and M5, hairy cell leukemia, lymphoplasmacytic…
Immunohistochemistry (IHC)
CD123 labels plasmacytoid dendritic cells and is useful in diagnosing neoplasms derived from these cells as well as reactive conditions, such as histiocytic necrotizing lymphadentis.
Immunohistochemistry (IHC)
CD138 (Syndecan-1) positively stains normal tissue including B-cell precursors and plasma cells. Positive staining in tumors includes myeloma, primary effusion lymphoma. CD138 negative staining comprises mature B-cells and lymphomas (even…
Immunohistochemistry (IHC)
CD14 stains normal macrophages/monocytes, granulocytes (weak), Langerhans cells, dendritic cells, and B cells. Positive staining in diseased cells comprises B-cell chronic lymphocytic leukemia (B-CLL), follicular center cell lymphoma, diffuse large…
Immunohistochemistry (IHC)
CD15 (X-Hapten) plays a role in mediating phagocytosis, bactericidal activity, and chemotaxis. It is present on granulocytes, including neutrophils and eosinophils, and to a lesser degree on monocytes. CD15 is also expressed in Reed-Sternberg cells…
Immunohistochemistry (IHC)
CD163 antigen is restricted in its expression to the monocytic/macrophage lineage. It is present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles,…
Immunohistochemistry (IHC)
CD19 recognizes a 95kD cell surface glycoprotein which is expressed by cells of the B-cell lineage and follicular dendritic cells. CD19 is a co-receptor of CD21and is an important signal transduction molecule which is involved in the regulation of B…
Immunohistochemistry (IHC)
At least five CD1 genes (CD1a, b, c, d, and e) have been identified. CD1a is expressed on cortical thymocytes, Langerhans cells, and dendritic cells. It is absent on mature peripheral blood T-cells, but cytoplasmic expression is detected on…
Immunohistochemistry (IHC)