Immunohistochemistry (IHC)
… of NTRK protein overexpression caused by gene fusions. Correlation of IHC staining with molecular detection of TRK fusions is moderate; discrepant cases have been described. … NTRK fusion frequencies (5-25%) include papillary thyroid cancer (PTC), GIST without KIT/PDGFRA/RAS mutations, …
FISH, Molecular
… through a combination of next-generation sequencing (NGS) and FISH as noted below. Test reports include a summary … for these tumor suppressor genes. RNA Sequencing: Fusions (30 Genes): ABL1, ABL2, BCR, CRLF2, CSF1R, EPOR, … Ribera, J., Morgades, M. et al. A novel targeted RNA-Seq panel identifies a subset of adult patients with acute …
Immunohistochemistry (IHC)
… neuroendocrine system (DNES), including anterior pituitary, thyroid perifollicular C cells, parathyroid chief cells, pancreatic islet cells, intestinal … neuroendocrine system (DNES), including anterior pituitary, thyroid perifollicular C cells, parathyroid chief cells, …
Immunohistochemistry (IHC)
… at 17q25 and Xp11.2 engendering an ASPSCR1–TFE3 fusion gene. Use of this antibody is an aid in the … soft part sarcoma within the context of an antibody panel. Specimen Requirements A formalin-fixed, … at 17q25 and Xp11.2 engendering an ASPSCR1–TFE3 fusion gene. Use of this antibody is an aid in the …
Immunohistochemistry (IHC)
… Gal-3 has been found overexpressed in most malignant thyroid neoplasms. However, it was not detectable in normal … differentiate benign from malignant (Galectin 3-positive) thyroid neoplasms. Specimen Requirements A formalin-fixed, … Gal-3 has been found overexpressed in most malignant thyroid neoplasms. However, it was not detectable in normal …
Immunohistochemistry (IHC)
… PAX8 is involved in kidney cell differentiation, and thyroid development. PAX8 has been shown to be expressed in … (FFPE) tissues. PAX8 has been shown to be positive in thyroid and ovarian carcinomas. Specimen Requirements A … PAX8 is involved in kidney cell differentiation, and thyroid development. PAX8 has been shown to be expressed in …
Molecular
… DNA and RNA alterations through next-generation sequencing (NGS) as noted below. Test reports include a summary … GSKIP, JAK2, KMT2A, KRAS, MYC, RAD21, TP53 RNA sequencing Fusions (40 genes): ABL1, AFDN, AFF1, ALK, BCL11B, CBFB, … DNA and RNA alterations through next-generation sequencing (NGS) as noted below. Test reports include a summary …
Molecular
… DNA and RNA alterations through next-generation sequencing (NGS) as noted below. Test reports include a summary … MYC, PAX5, RAD21, REL, TNFRSF14, TP53, XPO1 RNA Sequencing Fusions (184 genes): ABI1, ABL1, ABL2, ACTN4, ADAMTS17, … Heme Cancers profile is a DNA (302 genes) + RNA (184 genes) panel that detects known mutations, CNVs and RNA fusions …
Immunohistochemistry (IHC)
… cells), respiratory and GI tract epithelium, pituitary parathyroid, and pancreatic islets and C cells of thyroid all stain positively for NSE. NSE is expressed in … pheochromocytomas and paragangliomas. Carcinoids, medullary thyroid carcinomas, pituitary adenomas and endocrine tumors …
Immunohistochemistry (IHC)
… sample in hairy cell leukemia, some melanomas, and some thyroid carcinomas. BRAF mutation is a strong molecular … sample in hairy cell leukemia, some melanomas, and some thyroid carcinomas. BRAF mutation is a strong molecular … sample in hairy cell leukemia, some melanomas, and some thyroid carcinomas. … 59 … A formalin-fixed, …
Molecular
… analyzes 12 genes through next-generation sequencing (NGS) and the CLL FISH Panel as noted below. Test orders include summary … clients who wish to perform the professional component. NGS (12 genes): ATM, BCL2, BIRC3, BTK, CARD11, CD79B, CXCR4, …
Immunohistochemistry (IHC)
… epididymal tubular epithelium, within the cytoplasm of parathyroid parenchymal cells and focally within the colloid of thyroid follicles. Other normal tissues do not express … epididymal tubular epithelium, within the cytoplasm of parathyroid parenchymal cells and focally within the colloid of …
Molecular
… CBFB-MYH11 Translocation Alternative Name CBFB-MYH11 Fusion Methodology Molecular Test Description Real-time … RT-PCR for quantitative detection of the inv(16) CBFB-MYH11 fusion transcript. Positive results are reported as ratio of the amount of fusion transcript with the amount of transcript from a …
Molecular
… t(15;17) Alternative Name PML-RARA Translocation, PML-RARA Fusion Methodology Molecular Test Description Real-time … RT-PCR for quantitative detection of the t(15;17) PML-RARA fusion transcript. Both long and short isoforms of the fusion transcript are detected. Positive results identify …
Immunohistochemistry (IHC)
… carcinomas of the bladder, endometrial adenocarcinomas, thyroid papillary, gallbladder carcinomas and lung … carcinomas of the bladder, endometrial adenocarcinomas, thyroid papillary, gallbladder carcinomas and lung …
Immunohistochemistry (IHC)
… from mesothelioma. It is also positive in some thyroid carcinomas. Breast carcinomas with ductal and … from mesothelioma. It is also positive in some thyroid carcinomas. Breast carcinomas with ductal and …
Molecular
… coverage for BRAF exons 11 & 15 is available in the RAS/RAF Panel. Testing is available separately or in combination … are found most frequently in melanoma (50-70%), papillary thyroid cancer (36-40%) and almost all hairy cell leukemia. … 15 mutations. … BRAF, V600E, melanoma, mutation analysis, thyroid cancer, colon cancer, colorectal cancer … 61 … FFPE …
Molecular
… Alternative Name RUNX1-RUNX1T1 Translocation, RUNX1-RUNX1T1 Fusion, AML1-ETO Translocation, AML1-ETO Fusion Methodology Molecular Test Description Real-time … for quantitative detection of the t(8;21) RUNX1-RUNX1T1 fusion transcript (formerly called AML1-ETO). Analytical …
In Situ Hybridization (ISH)
… of E6/E7 mRNA in up to 28 HPV subtypes with the complete panel: low risk (10 subtypes: 6, 11, 40, 43, 44, 54, 69, 70, … 53, 56, 58, 59, 66, 68, 73, 82). Testing with the complete panel is recommended, but orders for partial panels are accepted. Orderable components are (1) 16/18 High …
Molecular
… Real-time RT-PCR for detection of t(9;22) BCR-ABL1 fusion transcripts that result in p230 (e19a2) fusion proteins. Analytical sensitivity is 0.1%. Results are … found in patients with CML and ALL and can lead to e19a2 fusion transcript. Thus, p230 BCR-ABL1 contains additional …
Molecular
… RT-PCR for quantitative detection of t(9;22) BCR-ABL1 fusion transcripts that result in major p210 (e13a2 and/or e14a2) or minor p190 (e1a2) fusion proteins with option to add p230 detection (micro or … RT-PCR for quantitative detection of t(9;22) BCR-ABL1 fusion transcripts that result in major p210 (e13a2 and/or …
FISH
… due to proximity of breakpoints in the most common fusion rearrangement. Clinical Significance TP63 gene rearrangements encoding p63 fusion proteins define a subset of ALK-negative anaplastic … This test includes targeted analysis for the TBL1XR1/TP63 fusion, which has also been reported in diffuse large B-cell …
FISH, Immunohistochemistry (IHC), Molecular
… through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include … treatment decisions. A microsatellite instability (MSI) NGS result of “indeterminate” will create a reflex to MSI by … … chollangio, cholangiocarcinoma, cholangio cancer, gene fusion … 40 … 59 … 61 … Jain, A. et al. Cholangiocarcinoma …
Molecular
… Methodology Molecular Test Description Sequential testing panel including qualitative detection of JAK2 V617F, JAK2 … Necessity for NeoTYPE Myeloid Profiles … Sequential testing panel including qualitative detection of JAK2 V617F, JAK2 … 81270, 81403, 81219, 81402 … 10 … 20 … Sequential testing panel including analysis of JAK2 V617F, JAK2 Exon 12-14, …
Immunohistochemistry (IHC)
… Positive staining in tumors includes myeloma, primary effusion lymphoma. CD138 negative staining comprises mature … Positive staining in tumors includes myeloma, primary effusion lymphoma. CD138 negative staining comprises mature … Positive staining in tumors includes myeloma, primary effusion lymphoma. Negative staining includes mature B-cells & …