Alternative Name
ZRSR2 Gene Sequencing
Test Description

Bi-directional sequencing of exons 5 and 7-11 of the ZRSR2 gene.

Clinical Significance

ZRSR2 is a component of the RNA splicing complex, the spliceosome. Mutations are detected in 8% of MDS and 4% of CMML. Mutations in MDS have been associated with shorter overall survival and an increased rate of transformation to AML. Testing is useful for establishing diagnosis by distinguishing myeloid neoplasms from a reactive process and for assessing prognosis.

Specimen Requirements
  • Peripheral blood: 5 mL in EDTA tube.
  • Bone marrow: 2 mL in EDTA tube.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible; specimens <72 hours old preferred.

CPT Code(s)*
Turnaround Time

14 days

Level of Service

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.