Vascular endothelial growth factor (VEGF) is a glycoprotein involved in angiogenesis that promotes tumor progression and metastasis. VEGF is a mitogen for vascular endothelial cells derived from arteries, veins and lymphatics, but it is devoid of consistent mitogenic activity for other cell types. VEGF is expressed in many human tumor cells, including adenocarcinomas, such as pancreatic, hepatocellular, renal cell carcinoma and fibrosarcoma. In normal tissues, VEGF expression has been observed in activated macrophages, keratinocytes, hepatocytes, smooth muscle cells, Leydig cells, embryonic fibroblasts and bronchial and choroids plexus epithelium, renal glomerular visceral epithelium, and mesangial cells.
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
- One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Global: 48 hours, Tech-Only (stain only): 24 hours