Alternative Name
Topo2A, topoisomerase IIa
Test Description
Probes: TOP2A (17q21-q22) | Cen 17 (17p11.1-q11.1)
Disease(s): Breast cancer
Note: Available as a global test only.
Clinical Significance
TOP2A (topoisomerase IIa) amplification has been associated with positive response to anthracycline therapy in breast cancer patients.
Specimen Requirements
  • Pathology Report: A copy of the pathology report is required for TOP2A testing
  • Bone Marrow Aspirate: N/A
  • Peripheral Blood: N/A
  • Fresh, Unfixed Tissue: N/A
  • Fluids: N/A
  • Paraffin block: Send paraffin block
  • Cut slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88377x1 manual or 88374x1 automated
Turnaround Time
4 days
Level of Service

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.