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Stand-alone test. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD19, CD20, CD23, CD34, CD38, CD45, CD56, kappa, and lambda (17 markers). 

Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing. Markers are CD1a, CD3, CD7, CD11b, CD19, CD43,…

Available as global and tech-only. Please provide clinical history including the time after treatment. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly recommended. Clients who decline full phenotyping and…

Polymerase chain reaction (PCR) allows discrimination of individual members of the sufficiently diverse TCR-beta gene family. By using PCR amplification of the TCR-beta gene, a dominant clone can be identified in the majority of T-cell neoplasms.

Available as global and tech-only. Available as stand-alone test (as described here) or as add-on to panels. Markers are CD3, CD4, CD7, CD8, CD25, CD26, CD30, CD45, CD52, and CD279 (10 markers).

Available as global and tech-only. Please provide clinical history including the time after treatment. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly recommended. Clients who decline full phenotyping and…

This test provides qualitative detection of monoclonal T-cell receptor (TCR) beta gene rearrangements by PCR and fragment analysis according to BIOMED-2 consensus primer design. This test may be ordered concurrently with or after negative results in…

Detection of clonal T-cell receptor gamma (TCRG) gene rearrangements by PCR of variable and joining regions. T-Cell Receptor Beta Gene Rearrangement is offered separately and may be added to this gamma gene test.

Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing. Markers are CD3, CD4, CD7, CD8, CD16, CD45, CD56,…

T-cell leukemia/lymphoma protein 1 (TCL1) is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T-cell leukemia and B-cell…

Probes: TCL1 (14q32.1) Disease(s): mature T-cell leukemia, T-cell prolymphocytic leukemia (T-PLL), adult T-cell leukemia/lymphoma (ATLL)

T-cell receptor delta (TCR delta) is used as a phenotypic marker for TCR delta-expressing T-cells. TCR is a heterodimer composed of either alpha/beta or gamma/delta. TCR delta is expressed by thymocytes and a majority of peripheral (gamma/delta TCR-…

T Cell Receptor beta (TCRβ) is used as a phenotypic marker for TCRβ expressing T-cells. TCRβ is expressed by thymocytes and a majority of peripheral (α/β TCR-bearing) T-cells. This antibody does not cross-react with γ/Δ TCR-bearing T-cells.

TdT is a highly specific marker for the diagnosis and classification of acute lymphoblastic lymphoma/leukemias. The determination of TdT expression is most valuable when it is important to differentiate histologically between lymphoblastic lymphoma…

Bi-directional Sanger sequencing is performed using PCR primers designed to target mutations in the promoter region of TERT.

TET2 mutation analysis is performed by next-generation sequencing of all coding exons of the TET2 gene.

Overexpression of TFE3 is a sensitive and specific marker of Xp11 translocation in renal cell carcinomas. TFE3 is also expressed in alveolar soft part sarcoma the hallmark of which is a chromosomal rearrangement at 17q25 and Xp11.2 engendering an…

Thrombomodulin (TM) is a plasma membrane-related glycoprotein that has anticoagulant activity. TM antigen is found in several cell types, including megakaryocytes, mesangial cells, synovial cells, mesothelial cells, endothelial cells, and some…

The THxID BRAF test is an FDA-approved, PCR-based qualitative companion diagnostic performed on DNA extracted from FFPE melanoma tissue for detection of two mutations in the BRAF gene: V600E (c.1799T>A) and V600K (c.1798_1799delinsAA).

This antibody labels thyroglobulin (TGB) in follicular epithelial cells of the thyroid and colloid. Thyroglobulin antibody is useful in positive identification of thyroid carcinomas of the papillary and follicular types. Demonstration of…

TIA1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. Most anaplastic large cell lymphomas react with TIA1. TIA1 also reacts…

Expression of the transducing-like receptor (TLE) genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state. TLE1 antibody is an excellent discriminator of synovial…

Probes: TOP2A (17q21-q22) | Cen 17 (17p11.1-q11.1) Disease(s): Breast cancer Note: Available as a global test only.

Topoisomerase I (TOPO1)  is essential nuclear enzyme for replication and transcription during cell reproduction and DNA repair. Upregulation of TOPO1 increases with disease stage in colorectal and pancreatic cancers.

Toxoplasma is a crescent shaped sporozoan that lives as an intracellular parasite in various tissues of vertebrates and completes its life cycle in a single host. This antibody helps to identify the toxoplasma in FFPE tissues.