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T-Cell Receptor Beta Gene Rearrangement
- Molecular
This test provides qualitative detection of monoclonal T-cell receptor (TCR) beta gene rearrangements by PCR and fragment analysis according to BIOMED-2 consensus primer design. This test may be ordered concurrently with or after negative results in our T-Cell Receptor Gamma Gene Rearrangement assay for gamma gene rearrangements to improve TCR rearrangement detection by ~10% in T-cell leukemias/lymphomas.
Turnaround time
7 Days
Level of Service
- Global
New York Approved: Yes
Specimen Requirements
Peripheral blood: 5 mL in EDTA tube. Bone marrow: 2 mL in EDTA tube. FFPE tissue: Paraffin block with at least 5mm2 of tissue size is preferred. Alternatively, send 1 H&E slide plus 4-5 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives. Fresh tissue: Two pieces minimum, 0.2 cm3 in RPMI. Note: not suitable for Freeze & Hold option. Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees. Note: Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.
Storage and Transportation
Please select extract & hold - DNA if specimen hold service is desired. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
81340
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: January 22, 2025