Displaying 1 - 20 of 26 tests
S100
S100 belongs to the family of calcium binding proteins. Antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign melanocytic lesions, melanomas and their metastases. S100 protein is also expressed in the Langerhans cells in skin and interdigitating reticulum cells in the
Immunohistochemistry (IHC)
S100p
Expression of S100P, a member of the S100 family, is increased in a number of tumors, including pancreas, lung, breast, and ovary carcinomas. S100P can be seen in many pancreatic ductal carcinoma, and it displays no staining in the benign pancreatic ducts and acinar glands.
Immunohistochemistry (IHC)
SALL4
SALL4, a newly identified zinc-finger transcriptional factor, is required for the maintenance of embryonic stem cell pluripotency by modulating OCT4. SALL4 is a novel sensitive and highly specific marker for metastatic germ cell tumors, and is particularly useful for detecting metastatic yolk sac
Immunohistochemistry (IHC)
SAT B2
SATB2 stains colonic and osteogenic cells and their neoplasms.
Immunohistochemistry (IHC)
Serotonin
Serotonin is synthesized in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract and serotonin-containing carcinoid tumors. Serotonin may be a useful tool for characterization of carcinoids.
Immunohistochemistry (IHC)
SETBP1 Mutation Analysis
Bi-directional sequencing of the SETBP1 exon 4 mutation hotspot (covering amino acids 823-941). The locked nucleic acid (LNA) technique is used to increase detection sensitivity for mutations at D868, G870, I871, and D880.
Molecular
Sezary T-Cell Add-On Flow Panel
Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing. Markers are CD3, CD4, CD5, CD7, CD8, CD19, CD26, CD43, and CD45 (9 markers).
Flow Cytometry
SF1
SF1 is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli cells, and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF1 is highly valuable marker to determine adrenocortical origin.
Immunohistochemistry (IHC)
SF3B1 Mutation Analysis
RT-PCR and bi-directional sequencing of exons 14-17 of the SF3B1 gene. More than 90% of reported mutations are detected in these exons. This test detects mutations present at 10-15% or more in a wild-type background.
Molecular
Simian Virus 40 (SV40)
Simian Virus 40 (SV40) is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors. SV40 is believed to suppress the tumor-suppressing p53 in humans. A mutated p53 gene may contribute to uncontrolled cellular
Immunohistochemistry (IHC)
SMA
Smooth muscle actin antibody binds to smooth muscle cells and myoepithelial cells. It stains the muscularis propria and muscularis mucosae of the gastrointestinal tract, the uterine myometrium, medial layer of blood vessels, myoepithelial cells of salivary glands and other organs. The antibody does
Immunohistochemistry (IHC)
SMMHC
Smooth Muscle Myosin, Heavy Chain (SMMS-1) is an antibody to smooth muscle myosin, heavy chain that reacts with human visceral and vascular smooth muscle cells. The antibody also reacts with human myoepithelial cells. It is very helpful in distinguishing between benign sclerosing breast lesions and
Immunohistochemistry (IHC)
Smoothelin
Smoothelin is a novel cytoskeletal protein that reacts with the 59 kDa and 100 kDa proteins corresponding to Smoothelin A and B, respectively, which are exclusively found in smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as
Immunohistochemistry (IHC)
Somatostatin
Somatostatin is a useful marker of D-cells of pancreatic islet cells. D-cells are used to identify hyperplasia of the pancreatic islets. Most of these tumors are malignant, giving rise to somatostatinomas. Somatostatin suppresses gastric acid secretion, gallbladder contractions and pancreatic
Immunohistochemistry (IHC)
Somatostatin (Receptor Type 2)
Somatostatin receptor type 2 (sstr2) is a receptor for somatostatins-14 and -28. This antibody has a great value in the assessment of sst2A status in human neuroendocrine tumors. Overexpression of somatostatin receptor 2 (Sst2r) in neuroendocrine tumors is diagnostically helpful and may have
Immunohistochemistry (IHC)
SOX10
SOX10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is also a useful marker in detecting both the in situ and invasive components of desmoplastic melanoma. SOX10 is diffusely expressed in schwannoma, neurofibroma, and granular cell tumor. SOX10
Immunohistochemistry (IHC)
SOX11
Nuclear protein expression of SOX-11 is highly associated with both cyclin D1-positive and negative mantle cell lymphoma (MCL). SOX-11 IHC is useful for identifying true cyclin D1-negative MCL and further defining pathologic features of CD5+ DLBCL. Routine use of anti-SOX-11 in cases of suspected
Immunohistochemistry (IHC)
SOX2
SOX2 stains all embryonal carcinomas and is highly specific for squamous cell carcinoma.
Immunohistochemistry (IHC)
Spirochete
Spirochete ( Treponema pallidum ) is the causative agent of syphilis. In the past, localization of the spirochete agent was achieved with silver stains such as Steiners and/or Warthin-Starry. Treponema pallidum can now be successfully localized with IHC techniques in FFPE tissue. The antibody
Immunohistochemistry (IHC)
SRSF2 Mutation Analysis
Bi-directional sequencing of the mutation hotspot region in exon 1 of the SRSF2 gene corresponding to amino acids 57-120.
Molecular