Displaying 1 - 13 of 13 tests
RARA Break-Apart
Disease(s): APL, AML Probes: RARA (17q21)
FISH
RAS/RAF Panel
The RAS/RAF Panel is an NGS-based assay performed by sequencing the entire coding region (full gene) of BRAF, HRAS, KRAS and NRAS genes. The panel reports mutations detected in the full gene including mutations in the most common hotspots, if present. The common hotspots include KRAS (exons 2-4,
Molecular
RB (Retinoblastoma Protein)
Retinoblastoma ( RB ) is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. RB protein may act by regulating transcription and loss of its function leads to uncontrolled cell
Immunohistochemistry (IHC)
RCC1
In normal kidney, renal cell carcinoma (RCC1, gp200) is localized along the brush border of the proximal tubule. In other normal tissues, RCC is also localized along the luminal surfaces of breast lobules and ducts, the luminal surface of the epididymal tubular epithelium, within the cytoplasm of
Immunohistochemistry (IHC)
RET FISH
Probes: RET (10q11.2) Disease(s): Lung cancer, thyroid cancer
FISH
Reticular Nuclear Fast Red Stain
Special stain.
Immunohistochemistry (IHC)
RHOA Mutation Analysis
Bi-directional sequencing of the gene RHOA. The locked nucleic acid (LNA) technique is used to increase detection sensitivity for the G17V mutation. Note - Available as stand-alone or as part of the NeoTYPE AITL/Peripheral T-Cell Lymphoma Profile.
Molecular
ROS1
ROS1 gene rearrangements are reported in 1% to 2% of lung adenocarcinomas and are associated with a response to the multi-targeted tyrosine kinase inhibitor crizotinib. ROS1 rearrangement can be detected by using IHC for ROS1 protein as an alternate screening test. We recommend that any positive
Immunohistochemistry (IHC)
ROS1
Probes: ROS1 (6q22.1) Disease(s): Non-small cell lung carcinoma (NSCLC)
FISH
RRM1
RRM1 is crucial for DNA synthesis and damage repair. High levels of RRM1 are associated with G2 cell cycle arrest and increased apoptosis in vitro.
Immunohistochemistry (IHC)
RUNX1 Mutation Analysis
Bi-directional sequencing of exons 4-10 of the RUNX1 gene
Molecular
RUNX1-RUNX1T1 (AML1-ETO) Translocation, t(8;21)
Real-time RT-PCR for quantitative detection of the t(8;21) RUNX1-RUNX1T1 fusion transcript (formerly called AML1-ETO). Analytical sensitivity is 1 tumor cell in 100,000 normal cells. Positive results are reported as a ratio between quantities of (8;21) transcript and a normal control gene.
Molecular
RUNX1T1/RUNX1 (ETO/AML1) t(8;21)
Probes: RUNX1T1/RUNX1 (ETO/AML1) t(8;21) Disease(s): AML-M2
FISH