Displaying 1 - 20 of 54 tests
MAL
MAL is a distinct molecular marker of primary mediastinal large B-cell lymphoma subtype among diffuse large B-cell lymphomas.
Immunohistochemistry (IHC)
MALT1 (18q21)
Probes: MALT1 (18q21) Disease(s): Marginal zone B-cell lymphoma, NHL
FISH
Mammaglobin
Mammaglobin is a breast-associated glycoprotein. In normal breast tissue, this antibody labels breast ductal and lobular epithelial cells. In tumor cells, they are reactive with all types of breast adenocarcinoma regardless of tumor differentiation and type. Adenocarcinomas from other organs rarely
Immunohistochemistry (IHC)
Masson Trichrome
Special stain.
Immunohistochemistry (IHC)
Mast Cell Add-On Flow Panel
Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing. Markers are CD2, CD25, CD34, CD45, and CD117 (5 markers).
Flow Cytometry
MDM2
Probes: MDM2 (12q15) | Centromere 12 Disease(s): Liposarcoma
FISH
MDM2 by IHC Immunohistochemistry (IHC)
MDS Add-On Flow Panel
Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing. Markers are CD11b, CD13, CD36, CD41, CD45, CD71, CD117, and CD235a (8 markers).
Flow Cytometry
MDS Extended FISH Panel
Probes: RPN1, MECOM (3q21, 3q26.2) | 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | ETV6 (12p13) | 17p- (TP53 17p13.1, NF1 17q11.2) | +19 (19p13.2, 19q13) | 20q- (20q12, 20qter) Probes may be ordered separately except +8 and 20q- which are combined.
FISH
MDS FISH Panel (New York)
Probes: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (7q31, Cen 7) | Trisomy 8 (Cen 8) | MLL (11q23) | 20q- (20q12, 20qter) Probes may be ordered separately except +8 and 20q- which are combined. Disease(s): Myelodysplastic syndrome
FISH
MDS Standard FISH Panel
Probes: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | 20q- (20q12, 20qter) Probes may be ordered separately except +8 and 20q- which are combined. Disease(s): Myelodysplastic syndrome
FISH
Melan A (Mart1)
Melan A (Mart1, Melanoma Antigen Recognized by T-cells 1), is a differentiation antigen that is expressed in melanocytes, most melanomas. Melan A recognizes a subcellular fraction found in melanosomes. Melan A is a useful addition to melanoma panels since it is specific for melanocytic lesions. Both
Immunohistochemistry (IHC)
Mesothelin
Mesothelin is a 40kDa cell surface glycoprotein selectively expressed by mesothelial cells and malignant mesotheliomas, as well as by non-mucinous ovarian carcinomas, breast carcinomas, pancreatic carcinomas, and squamous tumors of the esophagus and cervix.
Immunohistochemistry (IHC)
MET (c-MET) Mutation Analysis
Bi-directional Sanger sequencing of MET is performed using PCR primers designed to target hotspot mutations in exons 14, 16, 17 and 19.
Molecular
MET Exon 14 Deletion Analysis
MET Exon 14 Deletion Analysis is performed by real-time quantitative RT-PCR. The assay is designed to detect alternative splice junctions that lead to exon-skipping (deletion) of exon 14 of the gene MET. Note: Available as stand-alone test or as part of the NeoTYPE® Lung Tumor Profile.
Molecular
MET FISH
Probes: MET (7q31) | Centromere 7 Disease(s): Multiple solid tumor cancers including lung (NSCLC), gastric, esophageal, endometrial
FISH
MGMT
MGMT (O-6-methylguanine-DNA methyltransferase) is a DNA repair enzyme. MGMT protects cells from alkylating toxins, and is an important factor in drug resistance to alkylating therapeutic agents. It is expressed in normal human tissues and is overexpressed in many types of tumors, but epigenetically
Immunohistochemistry (IHC)
MGMT Promoter Methylation Analysis
Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the MGMT gene promoter. Percentage of methylated DNA (compared to total DNA) is reported for positive results.
Molecular
Microsatellite Instability Analysis (MSI)
PCR and fragment analysis of paired normal and tumor tissue to determine microsatellite instability (MSI) at the standard five NCI-recommended loci. Positive results are reported as MSI-high (at least two markers are unstable) or MSI-low (one marker is unstable).
Molecular
MITF
MITF (microphthalmia transcription factor) is a transcription factor that regulates the development and survival of melanocytes. MITF is restricted to the melanocyte cell lineage. Anti-MITF recognizes a nuclear protein that is expressed in the majority of primary and metastatic epithelioid malignant
Immunohistochemistry (IHC)