Displaying 1 - 10 of 10 tests
D2 40 identifies a 40kDa O-linked sialoglycoprotein expressed by a variety of tissues, including fetal testes and testicular germ cell tumors. Anti-D2 40 has also been demonstrated to label lymphatic endothelium whereas it is unreactive with vascular endothelium. In neoplastic tissue, immunostaining
Immunohistochemistry (IHC)
This antibody reacts with a subset of B-cells in the mantle zone and some immunoblasts outside the follicle. It reacts with most hairy cell leukemia cases. This antibody shows strong positive staining in some high grade B-cell lymphoma cases.
Immunohistochemistry (IHC)
Probes: DDIT3 (CHOP) (12q13) Disease(s): Myxoid-round cell liposarcoma (M/RCLS)
Desmin is an intermediate filament protein of both smooth and striated muscles. Antibody to desmin reacts with striated (skeletal and cardiac) as well as smooth muscle cells. Anti-desmin antibody is useful in identification of tumors of myogenic origin. It reacts with leiomyosarcomas (smooth muscle)
Immunohistochemistry (IHC)
DNA Ploidy/Cell Cycle Analysis – Heme
Available as a global test only. DNA stain is DRAQ5™ to determine S-phase cell cycle fraction and DNA index as indicators of DNA ploidy in fresh leukemia or lymphoma specimens. Two markers will be added for gating; which specific markers are used depends on the phenotype of the abnormal population.
Flow Cytometry
DNA Ploidy/Cell Cycle Analysis – POC/Solid Tumors
Available as a global test only. DNA stain propidium iodide (PI) is used to determine S-phase cell cycle fraction and DNA index as indicators of DNA ploidy. Products of conception (POC) and solid tumors are accepted for this test. Please see DNA Ploidy/Cell Cycle Analysis – Heme for other
Flow Cytometry
DNMT3A Mutation Analysis
Bi-directional sequencing of exon 26, a mutation hotspot region containing R882 and other mutations. In hematological disease, testing may be performed on plamsa to increase sensitivity. For solid tumors, tumor enrichment is performed before extraction.
DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). Among GIST cases with Kit mutations the DOG1 antibody identified 11% more cases than c-Kit antibody. DOG1 identifies the vast majority of both cKIT negative and Platelet-derived Growth
Immunohistochemistry (IHC)
The gene DPC4 (deleted in pancreatic carcinoma 4, also called SMAD4) was identified in 18q21.3 This gene is frequently mutated and deleted in pancreatic carcinomas (55%) and less frequently (20 - 22%) in colon carcinomas. Loss of expression is specific for pancreatic malignancy (in-situ or invasive)
Immunohistochemistry (IHC)
DUSP22-IRF4 Rearrangement
Probes: DUPS22-IRF4 gene region at 6p25.3 Disease(s): Anaplastic Large Cell Lymphoma (ALCL), large B-cell lymphoma