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Alternative Name
SRSF2 Gene Sequencing
Test Description

SRSF2 mutation analysis is performed by next-generation sequencing of all coding exons of the SRSF2 gene.

Clinical Significance

SRSF2 is a component of the RNA splicing complex, the spliceosome. Mutations are frequent in myeloid disorders including 12% MDS, 44% CMML, and 17% primary myelofibrosis (PMF), and are associated with poorer prognosis in these patients. Testing is useful for establishing diagnosis by distinguishing myeloid neoplasms from a reactive process and for assessing prognosis.

Specimen Requirements
  • Peripheral blood: 5 mL in EDTA tube.
  • Bone marrow: 2 mL in EDTA tube.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
81348 (as of 01/01/2021); Prior to CPT Code was 81479
New York Approved
Level of Service
Turnaround Time

14 days

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.